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Gene Review

EBNA1BP2  -  EBNA1 binding protein 2

Homo sapiens

Synonyms: EBNA1-binding protein 2, EBP2, NOBP, Nucleolar protein p40, P40
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Disease relevance of EBNA1BP2


High impact information on EBNA1BP2

  • EBNA1 expression alone did not enable the stable segregation of FR-containing plasmids in yeast, but segregation was rescued by human EBP2 [2].
  • When expressed in yeast, hEBP2 undergoes the same cell cycle-regulated association with the mitotic chromatin as in human cells, and using yeast temperature-sensitive mutant strains, we found that the attachment of hEBP2 to mitotic chromosomes was dependent on the Ipl1 kinase [3].
  • We have previously identified a mitotic chromosomal protein, human EBNA1 binding protein 2 (hEBP2), which binds to EBNA1 and enables EBNA1 to partition EBV-based plasmids in Saccharomyces cerevisiae [3].
  • P40 was not detected in normal human kidney, liver, and leukocytes but was readily demonstrable in a variety of human malignant tissues [4].
  • EBNA1BP2, involved in ribosome biogenesis, is an example of such a gene, with its depletion arresting MCF10A at G1/S in a p53-dependent manner [5].

Biological context of EBNA1BP2

  • The human p40/EBP2 gene is located in chromosome 1 with nine exons and eight introns [6].
  • An EBNA1 mutant (delta325-376) disrupted for EBP2 binding and segregation function was nuclear but failed to attach to the cellular chromosomes in mitosis [7].
  • Hybridization analyses demonstrate that the amount of RcC/EBP-2 mRNAs in tadpole liver remains constant throughout metamorphosis, whereas RcC/EBP-1 mRNAs are up-regulated during both spontaneous and TH-induced metamorphosis [8].

Anatomical context of EBNA1BP2

  • A novel Plasmodium falciparum erythrocyte binding protein-2 (EBP2/BAEBL) involved in erythrocyte receptor binding [9].
  • Maintenance of Epstein-Barr virus-derived episomal vectors in the murine Sp2/0 myeloma cell line is dependent upon exogenous expression of human EBP2 [10].
  • When the lesions were located primarily in the ventro-posterior thalamus, the SEP changes consisted of the following combination: absence of response; decrease in response amplitude; delay in peak latency; and attenuation of median N20-P25 and tibial P40 [11].

Associations of EBNA1BP2 with chemical compounds

  • Similar to EBA-175, the binding of EBP2/BAEBL to human erythrocytes was dependent on sialic acids because neuraminidase treatment of those erythrocytes rendered them incapable of binding, but differed from EBA-175 in that trypsin treatment decreased EBP2/BAEBL binding by only twofold compared to a 10-fold reduction in EBA-175 binding [9].

Analytical, diagnostic and therapeutic context of EBNA1BP2


  1. EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding protein 2 on mitotic chromosomes. Kapoor, P., Frappier, L. J. Virol. (2003) [Pubmed]
  2. Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast. Kapoor, P., Shire, K., Frappier, L. EMBO J. (2001) [Pubmed]
  3. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. Kapoor, P., Lavoie, B.D., Frappier, L. Mol. Cell. Biol. (2005) [Pubmed]
  4. Identification and partial characterization of a Mr 40,000 nucleolar antigen associated with cell proliferation. Chatterjee, A., Freeman, J.W., Busch, H. Cancer Res. (1987) [Pubmed]
  5. Targeted comparative RNA interference analysis reveals differential requirement of genes essential for cell proliferation. Machida, Y.J., Chen, Y., Machida, Y., Malhotra, A., Sarkar, S., Dutta, A. Mol. Biol. Cell (2006) [Pubmed]
  6. Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2. Henning, D., Valdez, B.C. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. The DNA segregation mechanism of Epstein-Barr virus nuclear antigen 1. Wu, H., Ceccarelli, D.F., Frappier, L. EMBO Rep. (2000) [Pubmed]
  8. Characterization and expression of C/EPB-like genes in the liver of Rana catesbeiana tadpoles during spontaneous and thyroid hormone-induced metamorphosis. Chen, Y., Hu, H., Atkinson, B.G. Dev. Genet. (1994) [Pubmed]
  9. A novel Plasmodium falciparum erythrocyte binding protein-2 (EBP2/BAEBL) involved in erythrocyte receptor binding. Narum, D.L., Fuhrmann, S.R., Luu, T., Sim, B.K. Mol. Biochem. Parasitol. (2002) [Pubmed]
  10. Maintenance of Epstein-Barr virus-derived episomal vectors in the murine Sp2/0 myeloma cell line is dependent upon exogenous expression of human EBP2. Habel, M.E., Drouin, M., Jung, D. Biochem. Cell Biol. (2004) [Pubmed]
  11. Median and tibial somatosensory evoked potentials. Changes in short- and long-latency components in patients with lesions of the thalamus and thalamo-cortical radiations. Chu, N.S. J. Neurol. Sci. (1986) [Pubmed]
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