Disease relevance of Mott1

• However, neither the genesis nor the significance of Mott cells in autoimmune diseases is well understood [1].
• Upon fusion of NYC cells with a plasmacytoma, which itself produces no immunoglobulin, the resulting NYCH hybridoma cells are Mott cells; i.e., they contain large intracellular vesicles filled with immunoglobulin, the so-called Russell bodies [2].

High impact information on Mott1

• Moreover, unlike conventional Mott cells, the hybrid cells secrete immunoglobulin at a normal rate [2].
• Mott cells, a pathologic state of plasma cells containing intracellular inclusions of Igs (Russell bodies), are frequent in lymphoid tissues of murine and human autoimmune diseases [1].
• Cell surface phenotypes of Mott cells were B220+ CD5+ CD43+ CD11b(dull), while those of peritoneal macrophages were B220- CD5- CD43(dull) CD11b+ [1].
• These data suggest that Mott cells in mev/mev mice are thymic-dependent plasmacytoid cells resulting from chronic B-cell activation accompanied by impaired Ig secretion [3].
• Lymph node cell preparations which were enriched in Mott cells by velocity sedimentation failed to secrete Ig in a polyclonal reverse plaque assay [3].

Biological context of Mott1

• This occurred also in an inclusion-positive clone which maintained the original Ig status of the Mott without Sp1 kappa chain, indicating a complementation by the cell fusion of some cellular factor involved in Ig secretion [4].

Anatomical context of Mott1

• An obligate role of the thymus in Mott cell development is evidenced by the absence of Mott cells in neonatally thymectomized mev/mev mice and in mice doubly homozygous for the nude (nu) and mev mutations [3].
• Our examination of the Ig variable region gene sequences of two IgM Mott hybridomas derived from C.B-20 Ly-1 B cells showed all to be germ line [5].
• Furthermore, we injected Xenopus oocytes with mRNA isolated from three different original Mott cell hybridomas and could show secretion of the Ig, which is not secreted from the original Mott cells, from the oocytes [4].

Associations of Mott1 with chemical compounds

• A possible causal relationship between the elevated frequency of Mott cells in the Ly-1 B cell-derived LPS blasts and the repertoire selection inherent in the development of these B cells is discussed [5].
• In Romania, Usnea barbata was mentioned in 1929 among the plants known by Romanian people with popular names: "Bear's beard", "Trees' dandruff", "Woman's long hair" (1). "Farmacia naturii" (2) and "Flora medicinală a Romaniei" (3) have mentioned that Usnea barbata (L) Mott contains usnic acid-substance with broad antibiotic spectrum [6].

Analytical, diagnostic and therapeutic context of Mott1

• Russell bodies in Mott cells from mev/mev mice contain immunoglobulin (Ig) as shown by immunofluorescence microscopy at the light-microscopic level and by indirect protein A-immunogold localization at the electron-microscopic level [3].

References