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Gene Review

SCO4184  -  aerial mycelium formation protein

Streptomyces coelicolor A3(2)

Synonyms: SCD66.21, amfC
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Disease relevance of SCO4184


High impact information on SCO4184


Chemical compound and disease context of SCO4184


Biological context of SCO4184


Associations of SCO4184 with chemical compounds


Regulatory relationships of SCO4184


Other interactions of SCO4184

  • It also implied that translational arrest at the UUA codon in adpAc mRNA caused a polar effect on the downstream ornA, and that the poor translation of both genes contributes extensively to the deficiency of aerial mycelium formation in bldA mutants [15].
  • A chromosomal ramB disruption mutant of S. lividans was found to be severely defective in aerial mycelium formation. ramR could encode a 21-kDa protein with significant homology to the UhpA subset of bacterial two-component response regulator proteins [16].
  • Over-expression of ftsZ also inhibited morphological differentiation in S. lividans 1326, although aerial mycelium formation was less reduced [17].
  • Bald mutants of S. coelicolor, which are blocked in aerial mycelium formation, regain the capacity to erect aerial structures when exposed to a small hydrophobic protein called SapB, whose synthesis is temporally and spatially correlated with morphological differentiation [18].

Analytical, diagnostic and therapeutic context of SCO4184

  • Instead, a substance characterized only as an unidentified HPLC peak accumulated intracellularly in the late growth phase, just before aerial mycelium formation and antibiotic production [19].


  1. Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus. Kudo, N., Kimura, M., Beppu, T., Horinouchi, S. J. Bacteriol. (1995) [Pubmed]
  2. The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor. Elliot, M.A., Karoonuthaisiri, N., Huang, J., Bibb, M.J., Cohen, S.N., Kao, C.M., Buttner, M.J. Genes Dev. (2003) [Pubmed]
  3. The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Kodani, S., Hudson, M.E., Durrant, M.C., Buttner, M.J., Nodwell, J.R., Willey, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Leskiw, B.K., Lawlor, E.J., Fernandez-Abalos, J.M., Chater, K.F. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Genetic and biochemical characterization of EshA, a protein that forms large multimers and affects developmental processes in Streptomyces griseus. Saito, N., Matsubara, K., Watanabe, M., Kato, F., Ochi, K. J. Biol. Chem. (2003) [Pubmed]
  6. A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2). Kelemen, G.H., Viollier, P.H., Tenor, J., Marri, L., Buttner, M.J., Thompson, C.J. Mol. Microbiol. (2001) [Pubmed]
  7. An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus. Umeyama, T., Lee, P.C., Ueda, K., Horinouchi, S. Microbiology (Reading, Engl.) (1999) [Pubmed]
  8. An oligopeptide permease responsible for the import of an extracellular signal governing aerial mycelium formation in Streptomyces coelicolor. Nodwell, J.R., McGovern, K., Losick, R. Mol. Microbiol. (1996) [Pubmed]
  9. Involvement of sigma(H) and related sigma factors in glucose-dependent initiation of morphological and physiological development of Streptomyces griseus. Takano, H., Hosono, K., Beppu, T., Ueda, K. Gene (2003) [Pubmed]
  10. The bldC developmental locus of Streptomyces coelicolor encodes a member of a family of small DNA-binding proteins related to the DNA-binding domains of the MerR family. Hunt, A.C., Servín-González, L., Kelemen, G.H., Buttner, M.J. J. Bacteriol. (2005) [Pubmed]
  11. The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis. Kojima, I., Kasuga, K., Kobayashi, M., Fukasawa, A., Mizuno, S., Arisawa, A., Akagawa, H. J. Bacteriol. (2002) [Pubmed]
  12. Changes in patterns of ADP-ribosylated proteins during differentiation of Streptomyces coelicolor A3(2) and its development mutants. Shima, J., Penyige, A., Ochi, K. J. Bacteriol. (1996) [Pubmed]
  13. Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription. Kim, E.S., Hong, H.J., Choi, C.Y., Cohen, S.N. J. Bacteriol. (2001) [Pubmed]
  14. Characterization of the Streptomyces coelicolor A3(2) wblE gene, encoding a homologue of the sporulation transcription factor. Homerová, D., Sevcíková, J., Kormanec, J. Folia Microbiol. (Praha) (2003) [Pubmed]
  15. A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolor. Takano, E., Tao, M., Long, F., Bibb, M.J., Wang, L., Li, W., Buttner, M.J., Bibb, M.J., Deng, Z.X., Chater, K.F. Mol. Microbiol. (2003) [Pubmed]
  16. Cloning and analysis of a gene cluster from Streptomyces coelicolor that causes accelerated aerial mycelium formation in Streptomyces lividans. Ma, H., Kendall, K. J. Bacteriol. (1994) [Pubmed]
  17. Effects of increased and deregulated expression of cell division genes on the morphology and on antibiotic production of streptomycetes. van Wezel, G.P., van der Meulen, J., Taal, E., Koerten, H., Kraal, B. Antonie Van Leeuwenhoek (2000) [Pubmed]
  18. A surface active protein involved in aerial hyphae formation in the filamentous fungus Schizophillum commune restores the capacity of a bald mutant of the filamentous bacterium Streptomyces coelicolor to erect aerial structures. Tillotson, R.D., Wösten, H.A., Richter, M., Willey, J.M. Mol. Microbiol. (1998) [Pubmed]
  19. A relaxed (rel) mutant of Streptomyces coelicolor A3(2) with a missing ribosomal protein lacks the ability to accumulate ppGpp, A-factor and prodigiosin. Ochi, K. J. Gen. Microbiol. (1990) [Pubmed]
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