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Chemical Compound Review

Kasuminl     [N'-[(2R,3S,5S,6R)-5-amino-2- methyl-6-[(2S...

Synonyms: KASUGAMYCIN, SureCN70535, CHEMBL1631109, HSDB 6695, AK-85644, ...
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Disease relevance of Kasuminl


High impact information on Kasuminl

  • The methylation reaction was studied in vitro using ribosomes from a kasugamycin resistant mutant (ksgA) of Escherichia coli and purified methyl-transferase [6].
  • It has been known for many years that the absence of post-transcriptional modification at A1519 and the adjacent A1518 in strains lacking a functional KsgA methylase produces a kasugamycin resistance phenotype [7].
  • Mutations at A1519 conferred kasugamycin resistance and had minor effects on cell growth, whereas mutations at 1518 did not confer resistance and increased the doubling time of the cells dramatically [7].
  • Three ribosomal RNA mutations conferring resistance to the antibiotic kasugamycin were isolated using a strain of Escherichia coli in which all of the rRNA is transcribed from a plasmid-encoded rrn operon [7].
  • The were not sensitive to kasugamycin, the apaH- apaG- ksgA- strain filamented and stopped growing in the presence of this antibiotic at 600 micrograms/ml [8].

Chemical compound and disease context of Kasuminl

  • The "colicin" fragments comprising the 49 3'-terminal nucleotides of 16 S ribosomal RNA have been isolated from wild-type Escherichia coli and from a kasugamycin-resistant mutant that lacks methylation of two geminal adenine residues [9].
  • Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273: involvement of two types of acetyltransferases in resistance to astromicin group antibiotics [10].

Biological context of Kasuminl


Anatomical context of Kasuminl


Associations of Kasuminl with other chemical compounds

  • Ribostatic insults included disruption of ribosomal activity by mechanistically dissimilar agents such as blasticidin-S (BCS) (which binds 28S-rRNA to block peptidyl bond formation), kasugamycin (KSM) (which binds 18S-rRNA to prevent translational initiation), and cycloheximide (CHX) (which blocks A-site to P-site translocation of peptidyl-tRNA) [18].
  • Treatment with kasugamycin and puromycin (targeting ribosomal subunit association as well as its peptidyl-transferase activity) caused accumulation of mRNAs from ribosomal protein operons [19].
  • We further found that injection of KA and CH impairs production of Germ cell-less (Gcl) protein, which is required for pole cell formation [20].
  • Ribosomes from kasugamycin-resistant mutants Ksg A and Ksg C were as sensitive to minosaminomycin as those from each parent strain [21].

Gene context of Kasuminl


Analytical, diagnostic and therapeutic context of Kasuminl


  1. Ribosome structure: localization of N6,N6-dimethyladenosine by electron microscopy of a ribosome-antibody complex. Politz, S.M., Glitz, D.G. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  2. The rpoZ gene, encoding the RNA polymerase omega subunit, is required for antibiotic production and morphological differentiation in Streptomyces kasugaensis. Kojima, I., Kasuga, K., Kobayashi, M., Fukasawa, A., Mizuno, S., Arisawa, A., Akagawa, H. J. Bacteriol. (2002) [Pubmed]
  3. Kasugamycin-resistant mutants of Bacillus subtilis. Tominaga, A., Kobayashi, Y. J. Bacteriol. (1978) [Pubmed]
  4. Kasugamycin resistant mutants of Bacillus stearothermophilus lacking the enzyme for the methylation of two adjacent adenosines in 16S ribosomal RNA. Van Buul, C.P., Damm, J.B., Van Knippenberg, P.H. Mol. Gen. Genet. (1983) [Pubmed]
  5. In vitro and in vivo effects of kasugamycin on Leptospira icterohaemorrhagiae. Kitaoka, M., Mori, M., Arimitsu, Y. Jpn. J. Med. Sci. Biol. (1975) [Pubmed]
  6. Partial methylation of two adjacent adenosines in ribosomes from Euglena gracilis chloroplasts suggests evolutionary loss of an intermediate stage in the methyl-transfer reaction. Van Buul, C.P., Hamersma, M., Visser, W., Van Knippenberg, P.H. Nucleic Acids Res. (1984) [Pubmed]
  7. Isolation of kasugamycin resistant mutants in the 16 S ribosomal RNA of Escherichia coli. Vila-Sanjurjo, A., Squires, C.L., Dahlberg, A.E. J. Mol. Biol. (1999) [Pubmed]
  8. Design and characterization of Escherichia coli mutants devoid of Ap4N-hydrolase activity. Lévĕque, F., Blanchin-Roland, S., Fayat, G., Plateau, P., Blanquet, S. J. Mol. Biol. (1990) [Pubmed]
  9. High-resolution proton magnetic resonance studies of the 3'-terminal colicin fragment of 16 S ribosomal RNA from Escherichia coli. Assignment of iminoproton resonances by nuclear Overhauser effect experiments and the influence of adenine dimethylation on the hairpin conformation. Heus, H.A., van Kimmenade, J.M., van Knippenberg, P.H., Haasnoot, C.A., de Bruin, S.H., Hilbers, C.W. J. Mol. Biol. (1983) [Pubmed]
  10. Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273: involvement of two types of acetyltransferases in resistance to astromicin group antibiotics. Hotta, K., Ogata, T., Ishikawa, J., Okanishi, M., Mizuno, S., Morioka, M., Naganawa, H., Okami, Y. J. Antibiot. (1996) [Pubmed]
  11. Susceptibility to kasugamycin of Escherichia coli carrying conjugative and nonconjugative R plasmids. Danbara, H., Yoshikawa, M. Antimicrob. Agents Chemother. (1977) [Pubmed]
  12. Increased translational fidelity caused by the antibiotic kasugamycin and ribosomal ambiguity in mutants harbouring the ksgA gene. van Buul, C.P., Visser, W., van Knippenberg, P.H. FEBS Lett. (1984) [Pubmed]
  13. Conditional lethal mutants of Bacillus subtilis dependent on kasugamycin for growth. Pai, Y., Dabbs, E.R. Mol. Gen. Genet. (1981) [Pubmed]
  14. DNA sequencing and transcriptional analysis of the kasugamycin biosynthetic gene cluster from Streptomyces kasugaensis M338-M1. Ikeno, S., Aoki, D., Hamada, M., Hori, M., Tsuchiya, K.S. J. Antibiot. (2006) [Pubmed]
  15. A carbon-13 nuclear magnetic resonance study of the 3'-terminus of 16S ribosomal RNA of Escherichia coli specifically labeled with carbon-13 in the methylgroups of the m6(2)Am6(2)A sequence. Van Charldorp, R., Verhoeven, J.J., Van Knippenberg, P.H., Haasnoot, C.A., Hilbers, C.W. Nucleic Acids Res. (1982) [Pubmed]
  16. Translational accuracy and sexual differentiation in Chlamydomonas reinhardtii. Bulté, L., Bennoun, P. Curr. Genet. (1990) [Pubmed]
  17. Expression vectors for quantitating in vivo translational ambiguity: their potential use to analyse frameshifting at the HIV gag-pol junction. Cassan, M., Berteaux, V., Angrand, P.O., Rousset, J.P. Res. Virol. (1990) [Pubmed]
  18. Requirement for SAPK-JNK signaling in the induction of apoptosis by ribosomal stress in REH lymphoid leukemia cells. Johnson, C.R., Jiffar, T., Fischer, U.M., Ruvolo, P.P., Jarvis, W.D. Leukemia (2003) [Pubmed]
  19. Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12. Sabina, J., Dover, N., Templeton, L.J., Smulski, D.R., Söll, D., LaRossa, R.A. J. Bacteriol. (2003) [Pubmed]
  20. Role of mitochondrial ribosome-dependent translation in germline formation in Drosophila embryos. Amikura, R., Sato, K., Kobayashi, S. Mech. Dev. (2005) [Pubmed]
  21. Biochemical study of minosaminomycin in relation to the kasugamycin group antibiotics. Suzukake, K., Hori, M. J. Antibiot. (1977) [Pubmed]
  22. Escherichia coli kasugamycin dependence arising from mutation at the rpsI locus. Dabbs, E.R. J. Bacteriol. (1983) [Pubmed]
  23. Cloning and characterization of the KlDIM1 gene from Kluyveromyces lactis encoding the m2(6)A dimethylase of the 18S rRNA. Housen, I., Demonté, D., Lafontaine, D., Vandenhaute, J. Yeast (1997) [Pubmed]
  24. Escherichia coli DNA-directed beta-galactosidase synthesis in presence and absence of Ca2+. Jacobs, K.A., Schlessinger, D. Biochemistry (1977) [Pubmed]
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