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Gene Review

Tcrd  -  T cell receptor delta chain

Mus musculus

Synonyms: Tcr delta, Tcrdelta
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Disease relevance of Tcrd


High impact information on Tcrd

  • We identify the developmental stage during which the Tcrd locus 'opens' in early T cell progenitors and show that a single checkpoint controls gammadelta cell development during the penultimate CD4(-)CD8(-) stage [2].
  • Using mice expressing a reporter gene 'knocked into' the Tcrd constant region gene, we have characterized many of the events that mark the life of early gammadelta cells in the adult thymus [2].
  • Murine Tcrd and Tcra gene segments reside in a single genetic locus and undergo recombination in CD4- CD8- (double negative [DN]) and CD4+ CD8+ (double positive [DP]) thymocytes, respectively [3].
  • T-cell receptor delta-chain diversity in peripheral lymphocytes [4].
  • Recombination of murine Tcrd gene segments is known to be regulated, at least in part, by the Tcrd enhancer (Edelta) situated in the Jdelta2-Cdelta intron [5].

Biological context of Tcrd

  • To examine whether such "waves" of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor delta chain in human fetal and post-partum thymocytes and peripheral blood T cells [6].

Anatomical context of Tcrd


Other interactions of Tcrd


Analytical, diagnostic and therapeutic context of Tcrd


  1. Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis. Wormley, F.L., Steele, C., Wozniak, K., Fujihashi, K., McGhee, J.R., Fidel, P.L. Infect. Immun. (2001) [Pubmed]
  2. Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Prinz, I., Sansoni, A., Kissenpfennig, A., Ardouin, L., Malissen, M., Malissen, B. Nat. Immunol. (2006) [Pubmed]
  3. Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. Hawwari, A., Krangel, M.S. J. Exp. Med. (2005) [Pubmed]
  4. T-cell receptor delta-chain diversity in peripheral lymphocytes. Lacy, M.J., McNeil, L.K., Roth, M.E., Kranz, D.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Regulation of the murine Ddelta2 promoter by upstream stimulatory factor 1, Runx1, and c-Myb. Carabana, J., Ortigoza, E., Krangel, M.S. J. Immunol. (2005) [Pubmed]
  6. Analysis of early fetal T-cell receptor delta chain in humans. van der Stoep, N., de Krijger, R., Bruining, J., Koning, F., van den Elsen, P. Immunogenetics (1990) [Pubmed]
  7. Rearrangement patterns of T-cell receptor genes in the spleen of athymic (nu/nu) young mice. Palacios, R., Samaridis, J. Immunogenetics (1991) [Pubmed]
  8. Increase of gammadelta T lymphocytes in murine lungs occurs during recovery from pulmonary infection by Nocardia asteroides. Tam, S., King, D.P., Beaman, B.L. Infect. Immun. (2001) [Pubmed]
  9. Expression of the T cell receptor delta-chain repertoire in mouse lymph node. Olive, C. Immunol. Cell Biol. (1996) [Pubmed]
  10. A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor delta-chain-encoding gene. van der Lugt, N., Maandag, E.R., te Riele, H., Laird, P.W., Berns, A. Gene (1991) [Pubmed]
  11. Diversity of functional T-cell receptor delta-chain transcripts from bone marrow cells of athymic nude mice. Spiess, S., Kuhröber, A., Schirmbeck, R., Arden, B., Reimann, J. Immunology (1993) [Pubmed]
  12. Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene. Fehling, H.J., Laplace, C., Mattei, M.G., Saint-Ruf, C., von Boehmer, H. Immunogenetics (1995) [Pubmed]
  13. Treatment with either anti-CD4 or anti-CD8 monoclonal antibodies blocks alphabeta T cell-mediated rejection of intestinal allografts in mice. Newell, K.A., He, G., Hart, J., Thistlethwaite, J.R. Transplantation (1997) [Pubmed]
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