Disease relevance of Tcrd

• Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis [1].

High impact information on Tcrd

• We identify the developmental stage during which the Tcrd locus 'opens' in early T cell progenitors and show that a single checkpoint controls gammadelta cell development during the penultimate CD4(-)CD8(-) stage [2].
• Using mice expressing a reporter gene 'knocked into' the Tcrd constant region gene, we have characterized many of the events that mark the life of early gammadelta cells in the adult thymus [2].
• Murine Tcrd and Tcra gene segments reside in a single genetic locus and undergo recombination in CD4- CD8- (double negative [DN]) and CD4+ CD8+ (double positive [DP]) thymocytes, respectively [3].
• T-cell receptor delta-chain diversity in peripheral lymphocytes [4].
• Recombination of murine Tcrd gene segments is known to be regulated, at least in part, by the Tcrd enhancer (Edelta) situated in the Jdelta2-Cdelta intron [5].

Biological context of Tcrd

• To examine whether such "waves" of Tcrgd phenotypes can be found in man, we studied the V-region usage and junctional diversity of the T-cell receptor delta chain in human fetal and post-partum thymocytes and peripheral blood T cells [6].

Anatomical context of Tcrd

• We conclude that the spleen is one of the extrathymic sites where T-cell progenitors can rearranged Tcrd and Tcrg genes [7].
• The C57BL/6J-Tcrd mice were less capable of clearing the organism, and the polymorphonuclear leukocyte response lasted longer than in wild-type C57BL/6J mice [8].
• Expression of the T cell receptor delta-chain repertoire in mouse lymph node [9].
• A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor delta-chain-encoding gene [10].
• Diversity of functional T-cell receptor delta-chain transcripts from bone marrow cells of athymic nude mice [11].

Other interactions of Tcrd

• A similar exon/intron structure encoding corresponding parts of the mature polypeptide is found both in the Tcra and Tcrd constant region genes [12].
• Results showed that T-cell receptor delta-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma/delta T cells in Candida vaginitis [1].

Analytical, diagnostic and therapeutic context of Tcrd

• However, mice deficient in gammadelta T cells (T cell receptor delta chain knockout mice) rejected intestinal allografts in a manner indistinguishable from normal recipients [13].

References