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Gene Review

Scn2a1  -  sodium channel, voltage-gated, type II,...

Mus musculus

Synonyms: 6430408L10, A230052E19Rik, Nav1.2, Scn2a
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Disease relevance of Scn2a1


High impact information on Scn2a1


Anatomical context of Scn2a1


Other interactions of Scn2a1

  • Physical mapping by pulsed-field gel electrophoresis has established that Scn2a and Scn3a (genes encoding type II and type III sodium channel alpha-subunit isoforms) are physically linked and are separated by a maximum distance of 600 kb [6].
  • Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones [7].
  • During development, the channel subtypes expressed at the node undergo a transition from Nav1.2 to Nav1 [8].
  • These were then subjected to a bioassay on mice, an elaborate electrophysiological characterization on three cloned voltage-gated Na+ channels (Nav1.2, Nav1.5, and para), and a circular dichroism analysis [9].

Analytical, diagnostic and therapeutic context of Scn2a1

  • These residues were individually substituted resulting in 11 mutants and were subjected to a bioassay on mice, an electrophysiological characterization on three cloned voltage-gated Na+ channels (Nav1.2, Nav1.5 and para), a CD analysis and X-ray crystallography [10].


  1. Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea. Hossain, W.A., Antic, S.D., Yang, Y., Rasband, M.N., Morest, D.K. J. Neurosci. (2005) [Pubmed]
  2. Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Craner, M.J., Lo, A.C., Black, J.A., Waxman, S.G. Brain (2003) [Pubmed]
  3. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Rush, A.M., Craner, M.J., Kageyama, T., Dib-Hajj, S.D., Waxman, S.G., Ranscht, B. Eur. J. Neurosci. (2005) [Pubmed]
  4. Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons. Rasband, M.N., Taylor, C.M., Bansal, R. Glia (2003) [Pubmed]
  5. Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination. Rasband, M.N., Kagawa, T., Park, E.W., Ikenaka, K., Trimmer, J.S. J. Neurosci. Res. (2003) [Pubmed]
  6. Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Malo, D., Schurr, E., Dorfman, J., Canfield, V., Levenson, R., Gros, P. Genomics (1991) [Pubmed]
  7. Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. Rush, A.M., Dib-Hajj, S.D., Waxman, S.G. J. Physiol. (Lond.) (2005) [Pubmed]
  8. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. Rios, J.C., Rubin, M., St Martin, M., Downey, R.T., Einheber, S., Rosenbluth, J., Levinson, S.R., Bhat, M., Salzer, J.L. J. Neurosci. (2003) [Pubmed]
  9. Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1. Liu, L.H., Bosmans, F., Maertens, C., Zhu, R.H., Wang, D.C., Tytgat, J. FASEB J. (2005) [Pubmed]
  10. Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1. Ye, X., Bosmans, F., Li, C., Zhang, Y., Wang, D.C., Tytgat, J. J. Mol. Biol. (2005) [Pubmed]
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