Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Bmd1 - bone mineral density 1

Mus musculus

Yamada, Y. et al., Beamer, W.G. et al., Allan, G. et al., Mödder, U.I. et al., Zhao, M. et al., et al.

van't Hof, Macphee, Libouban, Helfrich, Ralston,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bmd1

Bone mineral density (BMD) in AZT-treated mice is decreased and histopathology shows marked osteopenia [1].

High impact information on Bmd1

Bone mineral density, bone volume, and bone formation rates were severely reduced, but osteoblast and osteoclast numbers were not significantly changed in the transgenic mice [2].
Bone mineral density (BMD) and bone mineral content (BMC) of total body were significantly lower in DcR3 transgenic mice as compared with wild-type controls [3].
Bone mineral density (BMD) of total bone, femur, tibia, and lumbar vertebrae was measured weekly by PIXImus [4].
Bone mineral density (BMD) is determined by both environmental influences and polygenic inheritance [5].
Bone mineral density (BMD) was significantly higher in nNOS knockout (KO) mice compared with wild-type controls, particularly the trabecular BMD (P < 0.01) [6].

Biological context of Bmd1

Bone mineral density (BMD) data were obtained by peripheral quantitative computed tomography (pQCT), and genotype data were obtained by Polymerase Chain Reaction (PCR) assays for polymorphic markers carried in genomic DNA of each mouse [7].

Anatomical context of Bmd1

Bone mineral density at the radius was measured by peripheral quantitative computed tomography and that for the lumbar spine, right femoral neck, right trochanter, right Ward's triangle, and total body was measured by dual-energy X-ray absorptiometry [8].

Associations of Bmd1 with chemical compounds

Bone mineral density decreased from 229+/-34mg/cm(3) of hydroxyapatite to 166+/-26mg/cm(3) following orchidectomy, and was maintained at 194+/-20mg/cm(3) with JNJ-26146900 treatment (P<0.05 relative to orchidectomy alone) [9].
Bone mineral density (BMD) at the lumbar vertebrae (L1-L4), ilium/sacrum, and total body was diminished by rosiglitazone treatment [10].

Analytical, diagnostic and therapeutic context of Bmd1

Bone mineral density was measured by dual-energy x-ray absorptiometry and peripheral quantitative computed tomography at baseline and after 2 months of sham surgery, ovx, or ovx plus E replacement [11].

References

AZT enhances osteoclastogenesis and bone loss. Pan, G., Wu, X., McKenna, M.A., Feng, X., Nagy, T.R., McDonald, J.M. AIDS Res. Hum. Retroviruses (2004) [Pubmed]
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. Zhao, M., Harris, S.E., Horn, D., Geng, Z., Nishimura, R., Mundy, G.R., Chen, D. J. Cell Biol. (2002) [Pubmed]
Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. Tang, C.H., Hsu, T.L., Lin, W.W., Lai, M.Z., Yang, R.S., Hsieh, S.L., Fu, W.M. J. Biol. Chem. (2007) [Pubmed]
Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. Iida-Klein, A., Zhou, H., Lu, S.S., Levine, L.R., Ducayen-Knowles, M., Dempster, D.W., Nieves, J., Lindsay, R. J. Bone Miner. Res. (2002) [Pubmed]
Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice. Klein, O.F., Carlos, A.S., Vartanian, K.A., Chambers, V.K., Turner, E.J., Phillips, T.J., Belknap, J.K., Orwoll, E.S. J. Bone Miner. Res. (2001) [Pubmed]
Regulation of bone mass and bone turnover by neuronal nitric oxide synthase. van't Hof, R.J., Macphee, J., Libouban, H., Helfrich, M.H., Ralston, S.H. Endocrinology (2004) [Pubmed]
Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Beamer, W.G., Shultz, K.L., Churchill, G.A., Frankel, W.N., Baylink, D.J., Rosen, C.J., Donahue, L.R. Mamm. Genome (1999) [Pubmed]
Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. Yamada, Y., Ando, F., Niino, N., Ohta, S., Shimokata, H. J. Mol. Med. (2002) [Pubmed]
A selective androgen receptor modulator that reduces prostate tumor size and prevents orchidectomy-induced bone loss in rats. Allan, G., Lai, M.T., Sbriscia, T., Linton, O., Haynes-Johnson, D., Bhattacharjee, S., Dodds, R., Fiordeliso, J., Lanter, J., Sui, Z., Lundeen, S. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis. Sorocéanu, M.A., Miao, D., Bai, X.Y., Su, H., Goltzman, D., Karaplis, A.C. J. Endocrinol. (2004) [Pubmed]
Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Mödder, U.I., Sanyal, A., Kearns, A.E., Sibonga, J.D., Nishihara, E., Xu, J., O'Malley, B.W., Ritman, E.L., Riggs, B.L., Spelsberg, T.C., Khosla, S. Endocrinology (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.