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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Ilium

 
 
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Disease relevance of Ilium

  • A 40-year-old woman, who suffered from severe rheumatoid arthritis causing avascular necrosis of the femoral head and protrusio acetabuli of the right hip, developed a severe spontaneous disruption of the symphysis pubis concomitant with a stress fracture of the left ilium adjacent to the left sacroiliac joint [1].
  • Decreased radiopharmaceutical uptake was noted on both bone and gallium scans in the case of acute hematogenous osteomyelitis of the right ilium (acetabular roof) [2].
  • Primary bone tumours of the pelvis in childhood--Ewing's sarcoma of the ilium, pubis and ischium (report of 30 cases). (Part I) [3].
 

High impact information on Ilium

  • We now show that targeted inactivation of the mouse Ptx1 gene severely impairs hindlimb development: the ilium and knee cartilage are absent and the long bones are underdeveloped [4].
  • Surprisingly, we have found that scapula and ilium do not develop in Emx2 knock-out mice [5].
  • One year treatment with risedronate or alendronate significantly suppressed trabecular remodeling in vertebrae (RIS 90%, ALN 95%) and ilium (RIS 76%, ALN 90%) without impairment of mineralization, and significantly increased microdamage accumulation in all skeletal sites measured [6].
  • The fall in pamidronate content was largest in vertebral body and least in the ilium [7].
  • However, the test is still the only way to actually measure whether vitamin B12 is being absorbed through the terminal ilium [8].
 

Biological context of Ilium

 

Anatomical context of Ilium

  • The anterior column, superior ilium, posterior column, ischium, and pubis regions of the pelvis were tested using 6.5-mm titanium alloy screws and a hydraulic servo-controlled 1321 Instron testing machine [10].
 

Associations of Ilium with chemical compounds

  • Following tumor resection, fixation was achieved by intraoperative placement of contoured titanium rods bilaterally into the ilium [11].
  • Assays on the isolated guinea pig ilium showed neurokinin alpha to have 81% and neurokinin beta to have 65% of the activity of Substance P [12].
  • A technique was devised to reconstruct the ilium with methylmethacrylate [13].
  • CONCLUSIONS: Trabecular microarchitecture of the ilium, whether studied by two- or three-dimensional methods, is better (greater bone volume, greater trabecular thickness, decreased trabecular spacing) after alendronate treatment than after two to three years of treatment with placebo [14].
  • Group 2 was given gentamicin by rapid IV injection, by SC injection into the space over the cranial angle of the scapula on the midline (SC site 1), and by SC injection just caudal to the crest of the ilium (SC site 2) [15].
 

Gene context of Ilium

  • An aqueous solution containing 0 microgram (vehicle), 100 micrograms or 400 micrograms recombinant human bFGF was percutaneously applied through a needle into the right ilium in rabbit, and the ilia were harvested 4 weeks after the application [16].
  • PAO seems not to have been previously reported in the ilium [17].
  • Osteolytic osteogenic sarcoma of ilium in 46-month-old boy [18].
  • Two DHS screws connected to each other were implanted in the pelvis (one DHS screw into each ilium) [19].
  • An aqueous solution containing 0 (vehicle), 25, 100, or 400 micrograms of basic fibroblast growth factor was injected via a needle into the ilium of rats [20].
 

Analytical, diagnostic and therapeutic context of Ilium

  • A hand-held spinal manipulation device, equipped with a preload control frame and impedance head, was used to deliver high-rate (<0.1 millisecond) PA manipulative thrusts (190 N) to several common spinal landmarks, including the ilium, sacral base, and L5, L4, L2, T12, and T8 spinous and transverse processes [21].

References

  1. Disruption of the symphysis pubis and fatigue fractures of the pelvis in a patient with rheumatoid arthritis. A case report. Tauber, C., Geltner, D., Noff, M., Malkin, C. Clin. Orthop. Relat. Res. (1987) [Pubmed]
  2. Decreased gallium uptake in acute hematogenous osteomyelitis. Ang, J.G., Gelfand, M.J. Clinical nuclear medicine. (1983) [Pubmed]
  3. Primary bone tumours of the pelvis in childhood--Ewing's sarcoma of the ilium, pubis and ischium (report of 30 cases). (Part I). Kozlowski, K., Campbell, J., Beluffi, G., Hoeffel, J.C., Morris, L., Pelizza, A., Sprague, P., Taccone, A., Arico, M., Stevens, M. Australasian radiology. (1989) [Pubmed]
  4. Hindlimb patterning and mandible development require the Ptx1 gene. Lanctôt, C., Moreau, A., Chamberland, M., Tremblay, M.L., Drouin, J. Development (1999) [Pubmed]
  5. Agenesis of the scapula in Emx2 homozygous mutants. Pellegrini, M., Pantano, S., Fumi, M.P., Lucchini, F., Forabosco, A. Dev. Biol. (2001) [Pubmed]
  6. Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Mashiba, T., Turner, C.H., Hirano, T., Forwood, M.R., Johnston, C.C., Burr, D.B. Bone (2001) [Pubmed]
  7. Pamidronate content and turnover in sternum, vertebral body, and iliac bones of dogs. King, L.E., Grynpas, M.D., Tomlinson, G., Vieth, R. Bone (1997) [Pubmed]
  8. Schilling test: physiologic basis for and use as a diagnostic test. Nickoloff, E. Critical reviews in clinical laboratory sciences. (1988) [Pubmed]
  9. Number of osteoprogenitor cells in human bone marrow markedly decreases after skeletal maturation. Nishida, S., Endo, N., Yamagiwa, H., Tanizawa, T., Takahashi, H.E. J. Bone Miner. Metab. (1999) [Pubmed]
  10. Screw-augmented fixation of acetabular components. A mechanical model to determine optimal screw placement. Stranne, S.K., Callaghan, J.J., Elder, S.H., Glisson, R.R., Seaber, A.V. The Journal of arthroplasty. (1991) [Pubmed]
  11. Spinal-pelvic fixation in patients with lumbosacral neoplasms. Jackson, R.J., Gokaslan, Z.L. J. Neurosurg. (2000) [Pubmed]
  12. Synthesis and biological activities of neurokinin alpha and beta. Folkers, K., Lu, Y.A., Rosell, S. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  13. Methylmethacrylate reconstruction of large iliac crest bone graft donor sites. Lubicky, J.P., DeWald, R.L. Clin. Orthop. Relat. Res. (1982) [Pubmed]
  14. Trabecular bone microarchitecture after alendronate treatment of osteoporotic women. Recker, R., Masarachia, P., Santora, A., Howard, T., Chavassieux, P., Arlot, M., Rodan, G., Wehren, L., Kimmel, D. Current medical research and opinion. (2005) [Pubmed]
  15. Bioavailability of gentamicin in dogs after intramuscular or subcutaneous injections. Wilson, R.C., Duran, S.H., Horton, C.R., Wright, L.C. Am. J. Vet. Res. (1989) [Pubmed]
  16. Local application of basic fibroblast growth factor into the bone increases bone mass at the applied site in rabbits. Nakamura, K., Kurokawa, T., Kato, T., Okazaki, H., Mamada, K., Hanada, K., Hiyama, Y., Aoyama, I., Nakamura, T., Tamura, M. Archives of orthopaedic and trauma surgery. (1996) [Pubmed]
  17. Primary subacute osteomyelitis of the ilium. Foy, M.A. Clin. Orthop. Relat. Res. (1989) [Pubmed]
  18. Osteolytic osteogenic sarcoma of ilium in 46-month-old boy. Milgrom, C., Kaplan, L., Fields, S., Pizov, G., Porat, S. Orthopaedic review. (1987) [Pubmed]
  19. The problem of stabilization after sacrectomy. Blatter, G., Halter Ward, E.G., Ruflin, G., Jeanneret, B. Archives of orthopaedic and trauma surgery. (1994) [Pubmed]
  20. Stimulation of endosteal bone formation by local intraosseous application of basic fibroblast growth factor in rats. Nakamura, K., Kurokawa, T., Kawaguchi, H., Kato, T., Hanada, K., Hiyama, Y., Aoyama, I., Nakamura, T., Tamura, M., Matsumoto, T. Revue du rhumatisme (English ed.) (1997) [Pubmed]
  21. Stiffness and neuromuscular reflex response of the human spine to posteroanterior manipulative thrusts in patients with low back pain. Colloca, C.J., Keller, T.S. Journal of manipulative and physiological therapeutics. (2001) [Pubmed]
 
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