Disease relevance of ACOT7

• The cDNA isolated for hBACH, when expressed in Escherichia coli, directed the expression of palmitoyl-CoA hydrolase activity and a 44-kDa protein immunoreactive to the anti-BACH antibody, which in turn neutralized the hydrolase activity [1].
• The association of nocturia with cardiac disease, diabetes, body mass index, age and diuretic use: results from the BACH survey [2].
• When the nuclear form of SREBP-2 gene was transfected into human neuroblastoma cells, transcription of a BACH gene promoter-luciferase reporter gene was activated through a sterol regulatory element (SRE) motif [3].
• The hybrid cells ACH1P were derived from fusion of primary male trophoblast cells with the HGPRT-defective choriocarcinoma cell line AC1-1 [4].
• We believe this constellation of symptoms represents a novel syndrome: LACH syndrome (leukoencephalopathy, arthritis, colitis, and hypogammaglobulinemia) [5].

High impact information on ACOT7

• The functional neuroanatomy of such elaborately skilled achievements was characterized in the present study by using (15)0-water positron emission tomography to image blindfolded pianists performing a concerto by J.S. Bach [6].
• However, mutation analysis failed to identify any mutation in the coding sequences for the mitochondrial acyl-CoA thioesterase II (MTE-II) or the cytosolic acyl-CoA thioesterase II (CTE-II) [7].
• This was consistent with dual staining of the cytosol and nucleus in certain neurons by immunohistochemistry using anti-BACH antibody [8].
• The mitochondrial targeting signals encoded by exons 1b and 1c were also functional and directed mitochondrial localization of BACH isoforms with the signals [8].
• Sterol Regulatory Element-Binding Protein-2 modulates human brain acyl-CoA hydrolase gene transcription [3].

Biological context of ACOT7

• Comparison of outcomes in elective partial vs radical nephrectomy for clear cell renal cell carcinoma of 4-7 cm Dash A, Vickers AJ, Schachter LR, Bach AM, Snyder ME, Russo P, Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY [9].

Associations of ACOT7 with chemical compounds

• In human brain cytosol, 85% of palmitoyl-CoA hydrolase activity was titrated by an anti-BACH antibody, which accounted for over 75% of the enzyme activity found in the brain tissue [1].
• This study also provides insights into BACH function in the interaction between the metabolism of acyl-CoAs and cholesterol in neurons [3].
• Brain acyl-CoA hydrolase (BACH) is responsible for most of the long-chain acyl-CoA hydrolyzing activity in the brain and is localized exclusively in neurons [3].

Other interactions of ACOT7

• Here, we describe a cytosolic long-chain acyl-CoA hydrolase (referred to as BACH) that is constitutively expressed in the brain, comparing it with other acyl-CoA hydrolases found in peripheral organs that have a role in fatty acid oxidation [10].

Analytical, diagnostic and therapeutic context of ACOT7

• Western blotting showed absence of bands at 37 kDa in MTLEs using an antibody against mouse BACH and at 140 kDa in MTLEs using anti-rat BACH [11].
• Limitations in immunotherapy with CD3 antibodies: comment on the article by drs. Chatenoud and bach [12].

References