Disease relevance of Urination Disorders

• When examined individually or in the aggregate, historical information, such as polyuria, nocturia, or home urine testing for glucose, and laboratory information, such as fasting or random blood glucose levels, were weak predictors of the actual mean concentration of blood glucose [1].
• The most frequently reported complaints other than thiazide-induced nocturia included dizziness, fatigue, nausea, rash, and/or pruritus [2].
• Desmopressin in the management of nocturia in patients with multiple sclerosis. A double-blind, crossover trial [3].
• CONCLUSIONS: The majority of nocturia patients tolerate desmopressin treatment without clinically significant hyponatremia [4].
• Pentosan polysulfate is not significantly different from placebo in treating nocturia associated with interstitial cystitis [5].

Psychiatry related information on Urination Disorders

• Fatigue, neuropsychiatric disorders, memory loss, nocturia, and polyurea were more common in patients with sHPT (p < 0.05), whereas pain in joints was more common in patients with rHPT (63 versus 52 percent; p < 0.001) [6].
• Although high plasma ANP levels are unlikely to be a primary cause of nocturia and nighttime incontinence, they may, when combined with other factors such as low antidiuretic hormone levels, sleep disorders, and low functional bladder capacity, contribute to these symptoms in some geriatric patients [7].
• Desmopressin for nocturia and enuresis associated with multiple sclerosis [8].

High impact information on Urination Disorders

• Nifedipine and nocturia [9].
• Immediately after each episode of nocturia during the PSG, patients were questioned about the reason they believed they had awakened [10].
• When patients were classified as responders or nonresponders in terms of bladder filling, urine flow, bladder emptying, weekly average of voids/24 hours, and nocturia, the proportion of patients responding to prazosin was significantly greater in all categories except bladder filling and emptying [11].
• In randomised, double-blind trials in MS patients with nocturia, nasal desmopressin reduced the mean number of nocturnal voiding episodes by 31-54% [12].
• RESULTS: In the nephrological group the incidence of high capacity bladder was 75%, residual urine 50%, UTI 43%, hesitancy 38%, intermittent flow 33%, bladder pain 33%, nighttime incontinence 29%, nocturia 24%, feeling of incomplete emptying 15%, daytime incontinence 14%, straining 14%, urgency 10%, burning sensation 10% and intermittency 5% [13].

Chemical compound and disease context of Urination Disorders

• Beneficial effects of desmopressin on nocturia were maintained and increased in patients completing 10 or 12 months of further treatment in a nonblind extension of short-term trials [12].
• To evaluate a novel approach to the symptomatic management of nocturia in patients with MS, we have conducted a trial of desmopressin acetate (1-desamino-8-D-arginine vasopressin), a synthetic analogue of antidiuretic hormone [3].
• For a person to reach a 50% or greater reduction in nocturia, the advantage of terazosin over placebo was 17 percentage points [14].
• This study was designed to investigate melatonin as a potential treatment for nocturia associated with bladder outflow obstruction in older men [15].
• Maximum urinary flow, frequency and nocturia were unchanged during pinacidil treatment, compared to the initial test and the placebo period [16].

Biological context of Urination Disorders

• OBJECTIVE: To evaluate the decrease in nocturnal diuresis, nocturnal polyuria and the safety of oral desmopressin in elderly subjects with nocturia [17].

Anatomical context of Urination Disorders

• After clinical remission cyclophosphamide must be continued for at least a year under hydration sufficient to cause nycturia in order to protect the bladder mucosa [18].
• The specific objectives were to study a) circadian changes in renal-endocrine function, including a comprehensive characterization of nocturia; b) cardiovascular-endocrine responses to a 90 degree tilt; c) erythrocyte functions, including intracellular organic phosphates and the Donnan ratio for chloride; and d) blood enzyme profiles [19].
• OBJECTIVE: To investigate the number of tryptase positive bladder mast cells and the level of urine tryptase in interstitial cystitis (IC), a bladder disorder which occurs mostly in women and is characterized by suprapubic pain, frequency and nocturia [20].

Gene context of Urination Disorders

• The only significant association of marker with symptom score was a positive correlation of IL-6 with nocturia [21].
• Mean 24-hour micturition frequency decreased from 9.8 to 6.3 voids and nocturia decreased from 4.1 to 2.9 episodes nightly [22].
• Moderate dysuria and difficulty in urinating were reported by 2-5% of patients treated with 3D CRT in contrast to 6-9% of patients treated with SRT; moderate urinary frequency and nocturia were reported by 18-24% treated with 3D CRT and 18-27% of patients in the SRT group [23].
• Atrial natriuretic peptide levels in geriatric patients with nocturia and nursing home residents with nighttime incontinence [7].
• More detailed physiologic studies are needed to understand better the pathophysiology of geriatric nocturia and nighttime incontinence and the role that AVP deficiency may play in these conditions [24].

Analytical, diagnostic and therapeutic context of Urination Disorders

• Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement [15].
• CONCLUSIONS: We confirmed the beneficial effect of intravesical instillation of capsaicin on voiding pattern in patients with hypersensitive disorders (frequency and nocturia) [25].
• The risk of hyponatremia in older adults using desmopressin for nocturia: a systematic review and meta-analysis [26].
• Diclofenac for treatment of nocturia caused by nocturnal polyuria: a prospective, randomised, double-blind, placebo-controlled crossover study [27].
• Evaluation of a synthetic vasopressin analogue for treatment of nocturia in benign prostatic hypertrophy. A double-blind study [28].

References