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Gene Review:

Hemgn - hemogen

Rattus norvegicus

Synonyms: Edag-1, Edag1, Hemogen, Hemopoietic gene protein, Hgn, ...

Chen, Y.J. et al., Wurtz, T. et al., Krüger, A. et al., Krüger, A. et al.

Wurtz, Krüger, Christersson, Lundmark,

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High impact information on Hemgn

Immunohistochemistry indicated strong RP59 presence in the cytoplasm of bone marrow cells and weaker presence in nuclei of osteoblasts [1].
These data indicated that marrow cells with high RP59 content were recruited into growing bone tissue [1].
Concerning more mature hematopoietic cell types, RP59 was observed in megakaryocytes and nucleated erythroblasts, but absent from lymphoid cells [2].
In addition, in vitro-formed blood vessels contained RP59-positive cells in the lumen [2].
Later, RP59 occurred in fetal liver cells and in circulating blood [2].

Biological context of Hemgn

ESW treatment increased total cell density and the proportion of RP59 positive cells in the defect region [3].
The reverse transcription/polymerase chain reaction method identified tooth RNA coding for RP59 [4].

Anatomical context of Hemgn

RP59 may help to study the transition of bone marrow cell to osteoblast in more detail [1].
In conclusion, RP59 was induced in early mesoderm [2].
In situ hybridisation of tooth tissue revealed RP59 RNA specifically in ameloblasts [4].
Mature chondrocytes and osteoblasts exhibited only slight RP59 immuno-reactivity [3].
Presence of mesenchymal stem cell was assayed by immuno-staining for RP59, a recently discovered marker, and also production of TGF-beta 1 and VEGF was monitored [3].

Analytical, diagnostic and therapeutic context of Hemgn

Antisera versus RP59 detected a single band of 90 kDa by Western blotting of femur extract [1].
Sequence analysis indicated that RP59 RNA from tooth and marrow had the same sequence [4].

References

A new protein expressed in bone marrow cells and osteoblasts with implication in osteoblast recruitment. Wurtz, T., Krüger, A., Christersson, C., Lundmark, C. Exp. Cell Res. (2001) [Pubmed]
RP59, a marker for osteoblast recruitment, is also detected in primitive mesenchymal cells, erythroid cells, and megakaryocytes. Krüger, A., Ellerström, C., Lundmark, C., Christersson, C., Wurtz, T. Dev. Dyn. (2002) [Pubmed]
Recruitment of mesenchymal stem cells and expression of TGF-beta 1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats. Chen, Y.J., Wurtz, T., Wang, C.J., Kuo, Y.R., Yang, K.D., Huang, H.C., Wang, F.S. J. Orthop. Res. (2004) [Pubmed]
Rat enamel contains RP59: a new context for a protein from osteogenic and haematopoietic precursor cells. Krüger, A., Somogyi, E., Christersson, C., Lundmark, C., Hultenby, K., Wurtz, T. Cell Tissue Res. (2005) [Pubmed]

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HEMGN	Bos taurus
HEMGN	Canis lupus familiaris
HEMGN	Homo sapiens
HEMGN	Macaca mulatta
Hemgn	Mus musculus
HEMGN	Pan troglodytes

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