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P2rx5  -  purinergic receptor P2X, ligand-gated ion...

Rattus norvegicus

Synonyms: ATP receptor, P2X purinoceptor 5, P2X5, Purinergic receptor
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High impact information on P2rx5

  • ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells [1].
  • Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed [2].
  • Rat P2X1 and P2X5 mRNAs are localized within common subsets of peripheral and central sensory neurons as well as spinal motoneurons [3].
  • On the other hand, alpha,beta-methylene-ATP, beta,gamma-methylene-ATP, and UTP were unable to induce any rise in [Ca2+]i. This pharmacological profile is consistent with expression of P2X2 and/or P2X5 purinergic receptor channels [4].
  • Conversely, ENaC increased the plasma membrane expression of P2X2, P2X(2/6), and P2X5 receptors [5].

Anatomical context of P2rx5


Associations of P2rx5 with chemical compounds

  • Similar calcium, conductance, and capacitance responses could be activated by 2-methylthio-ATP and ADP, consistent with mediation by a P2 type purinergic receptor [11].

Other interactions of P2rx5

  • During development the 1 day-old heart possessed an abundance of co-localised P2X2 and P2X5 small receptor clusters on the sarcolemma [8].
  • A small number of chromaffin cells showed positive immunoreaction for P2X5 and P2X7, with the relative occurrence of P2X7-immunoreactive chromaffin cells exceeding that of P2X5 [10].
  • Granular and microglial cells were labeled for P2X5 (weakly) and P2X4 receptors, respectively [12].

Analytical, diagnostic and therapeutic context of P2rx5

  • We identified the P2X subtypes present in BAECs using RT-PCR. mRNA was present for only three of seven family members: P2X4, P2X5, and P2X7 [13].
  • Localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia [14].


  1. ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells. Ryten, M., Dunn, P.M., Neary, J.T., Burnstock, G. J. Cell Biol. (2002) [Pubmed]
  2. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. Collo, G., North, R.A., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A., Buell, G. J. Neurosci. (1996) [Pubmed]
  3. Functional and biochemical evidence for heteromeric ATP-gated channels composed of P2X1 and P2X5 subunits. Lê, K.T., Boué-Grabot, E., Archambault, V., Séguéla, P. J. Biol. Chem. (1999) [Pubmed]
  4. Expression of purinergic receptor channels and their role in calcium signaling and hormone release in pituitary gonadotrophs. Integration of P2 channels in plasma membrane- and endoplasmic reticulum-derived calcium oscillations. Tomić, M., Jobin, R.M., Vergara, L.A., Stojilkovic, S.S. J. Biol. Chem. (1996) [Pubmed]
  5. Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors. Wildman, S.S., Marks, J., Churchill, L.J., Peppiatt, C.M., Chraibi, A., Shirley, D.G., Horisberger, J.D., King, B.F., Unwin, R.J. J. Am. Soc. Nephrol. (2005) [Pubmed]
  6. Molecular cloning and functional expression of a novel rat heart P2X purinoceptor. Garcia-Guzman, M., Soto, F., Laube, B., Stühmer, W. FEBS Lett. (1996) [Pubmed]
  7. P2X receptor immunoreactivity in the male genital organs of the rat. Lee, H.Y., Bardini, M., Burnstock, G. Cell Tissue Res. (2000) [Pubmed]
  8. Distribution of purinergic P2X receptors in the rat heart. Hansen, M.A., Bennett, M.R., Barden, J.A. J. Auton. Nerv. Syst. (1999) [Pubmed]
  9. P2 receptors in the thymus: expression of P2X and P2Y receptors in adult rats, an immunohistochemical and in situ hybridisation study. Glass, R., Townsend-Nicholson, A., Burnstock, G. Cell Tissue Res. (2000) [Pubmed]
  10. Distribution of P2X receptors in the rat adrenal gland. Afework, M., Burnstock, G. Cell Tissue Res. (1999) [Pubmed]
  11. Effects of P2 purinergic receptor stimulation in brown adipocytes. Lee, S.C., Pappone, P.A. Am. J. Physiol. (1997) [Pubmed]
  12. Changes in expression of P2X purinoceptors in rat cerebellum during postnatal development. Xiang, Z., Burnstock, G. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  13. P2X purinergic receptor channel expression and function in bovine aortic endothelium. Ramirez, A.N., Kunze, D.L. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  14. Localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia. Gröschel-Stewart, U., Bardini, M., Robson, T., Burnstock, G. Cell Tissue Res. (1999) [Pubmed]
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