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Gene Review:

odc1 - ornithine decarboxylase 1

Danio rerio

Synonyms: CHUNP6922, SO:0000704, fc54f04, fi06d08, odc, ...

Hascilowicz, T. et al., Lee, J.H. et al.

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Disease relevance of odc1

The recombinant protein of flounder ODC containing a short histidine tag at the carboxyl terminus was overexpressed in Escherichia coli BL21 (DE3) codon plus using an inducible T7 expression system, and was purified by Ni-NTA affinity chromatography [1].

High impact information on odc1

Comparison of the structure and nucleotide sequence of the ODC genes revealed that the gene is highly conserved in the flounder, zebrafish, and rat [1].
Ornithine decarboxylase (ODC) is a homodimeric enzyme dependent on pyridoxal 5'-phosphate [1].
Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio) [2].
Spermidine elicited a rapid decay of ODC activity and ODC protein in a protein synthesis-dependent manner [2].
When cellular polyamine levels increase, antizyme, an ornithine decarboxylase (ODC) inhibitory protein, is induced by polyamine-dependent translational frameshifting [2].

Anatomical context of odc1

The presence of ODC and antizyme inhibitor mRNAs was confirmed by Northern blotting in embryos and adult fish, as well as in a zebrafish-derived cell line (BRF41) [2].

References

Isolation and characterization of ornithine decarboxylase gene from flounder (Paralichthys olivaceus). Lee, J.H., Son, M.Y., Yoon, M.Y., Choi, J.D., Kim, Y.T. Mar. Biotechnol. (2004) [Pubmed]
Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio). Hascilowicz, T., Murai, N., Matsufuji, S., Murakami, Y. Biochim. Biophys. Acta (2002) [Pubmed]

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AGOS_AER087C	Ashbya gossypii ATCC 10895
ODC1	Bos taurus
odc-1	Caenorhabditis elegans
ODC1	Canis lupus familiaris
Odc2	Drosophila melanogaster
Odc1	Drosophila melanogaster
ODC1	Gallus gallus
ODC1	Homo sapiens
KLLA0B02673g	Kluyveromyces lactis NRRL Y-1140
LOC694559	Macaca mulatta
MGG_02441	Magnaporthe oryzae 70-15
Odc1	Mus musculus
NCU01271	Neurospora crassa OR74A
Os04g0136500	Oryza sativa Japonica Group
Os09g0543400	Oryza sativa Japonica Group
ODC1	Pan troglodytes
Odc1	Rattus norvegicus
SPE1	Saccharomyces cerevisiae S288c
spe1	Schizosaccharomyces pombe 972h-
odc1	Xenopus (Silurana) tropicalis

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