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Gene Review

ODC1  -  ornithine decarboxylase 1

Gallus gallus

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Disease relevance of ODC1

  • Infection with Rous sarcoma virus resulted in increased ornithine decarboxylase activity which preceded morphological alterations by at least 24 hr [1].
  • The observation that a noise field inhibits ODC activity changes is consistent with our speculation that MF-induced ODC activity changes during early development may be related to MF-induced neural tube defects at slightly later stages (which are also inhibited by the superposition of a noise field) [2].

High impact information on ODC1


Biological context of ODC1


Anatomical context of ODC1


Associations of ODC1 with chemical compounds


Other interactions of ODC1


Analytical, diagnostic and therapeutic context of ODC1


  1. Polyamine metabolism in normal and in virus-transformed chick embryo fibroblasts. Don, S., Bachrach, U. Cancer Res. (1975) [Pubmed]
  2. The superposition of a temporally incoherent magnetic field inhibits 60 Hz-induced changes in the ODC activity of developing chick embryos. Farrell, J.M., Barber, M., Krause, D., Litovitz, T.A. Bioelectromagnetics. (1998) [Pubmed]
  3. Putrescine is involved in the vitamin D action in chick intestine. Shinki, T., Tanaka, H., Takito, J., Yamaguchi, A., Nakamura, Y., Yoshiki, S., Suda, T. Gastroenterology (1991) [Pubmed]
  4. c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock. Lüscher, B., Eisenman, R.N. Mol. Cell. Biol. (1988) [Pubmed]
  5. Spermidine N1-acetyltransferase has a larger role than ornithine decarboxylase in 1 alpha,25-dihydroxyvitamin D3-induced putrescine synthesis. Shinki, T., Kadofuku, T., Sato, T., Suda, T. J. Biol. Chem. (1986) [Pubmed]
  6. Activity of ornithine decarboxylase and creatine kinase in soft and hard tissue of vitamin D-deficient chicks following parenteral application of 1,25-dihydroxyvitamin D3 or 24R,25-dihydroxyvitamin D3. Ittel, T.H., Ross, F.P., Norman, A.W. J. Bone Miner. Res. (1986) [Pubmed]
  7. Molecular cloning and sequence analysis of a chicken ornithine decarboxylase cDNA. Johnson, R., Bulfield, G. Anim. Genet. (1992) [Pubmed]
  8. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Tenenbaum, H.C., Heersche, J.N. Endocrinology (1985) [Pubmed]
  9. Cellular content and biosynthesis of polyamines during rooster spermatogenesis. Oliva, R., Vidal, S., Mezquita, C. Biochem. J. (1982) [Pubmed]
  10. Comparative effects of TGFbeta on proliferation of 7- and 14-day-old chick embryo fibroblasts and lack of involvement of the ODC/PA system in the TGFbeta signaling pathway. Evangelisti, R., Valeno, V., Bosi, G., Baroni, T., Bellucci, C., Carinci, P. J. Cell. Physiol. (1999) [Pubmed]
  11. Transcriptional inhibition in early chick embryos as a result of polyamine depletion. Löwkvist, B., Emanuelsson, H., Egyházi, E., Sjöberg, J., Långström, E., Heby, O. Dev. Biol. (1986) [Pubmed]
  12. Studies on sex-organ development. Oestrogenic effect on ornithine decarboxylase activity in the differentiating Müllerian ducts and other organs of the chick embryo. Teng, C.S., Teng, C.T. Biochem. J. (1978) [Pubmed]
  13. Distribution of ornithine decarboxylase activity induced by 1 alpha,25-dihydroxyvitamin D3 in chick duodenal villus mucosa. Takahashi, N., Shinki, T., Kawate, N., Samejima, K., Nishii, Y., Suda, T. Endocrinology (1982) [Pubmed]
  14. An in situ assay system to measure ornithine decarboxylase activity in primary cultures of chicken osteoblasts: effects of bone-seeking hormones. Löwik, C.W., van Zeeland, J.K., Herrmann-Erlee, M.P. Calcif. Tissue Int. (1986) [Pubmed]
  15. Ornithine decarboxylase activity in chick duodenum induced by 1 alpha, 25-dihydroxycholecalciferol. Shinki, T., Takahashi, N., Miyaura, C., Samejima, K., Nishii, Y., Suda, T. Biochem. J. (1981) [Pubmed]
  16. Alcohol-induced modulation of the insulin-like growth factor system in early chick embryo cranial tissue. Lynch, S.A., Elton, C.W., Carver, F.M., Pennington, S.N. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  17. Induction of ornithine decarboxylase activity in isolated chicken osteoblasts by parathyroid hormone: the role of cAMP and calcium. Löwik, C.W., Olthof, A.A., van Leeuwen, J.P., van Zeeland, J.K., Herrmann-Erlee, M.P. Calcif. Tissue Int. (1988) [Pubmed]
  18. Arginase, ornithine decarboxylase and S-adenosylmethionine decarboxylase in chicken brain and retina. Grillo, M.A., Fossa, T., Dianzani, U. Int. J. Biochem. (1983) [Pubmed]
  19. The effect of LH, FSH and pregnant mares' serum gonadotrophin on ornithine decarboxylase activity in thecal and granulosa tissue during follicular growth and atresia in laying hens (Gallus domesticus). Armstrong, D.G. J. Reprod. Fertil. (1994) [Pubmed]
  20. Localization of ornithine decarboxylase in the chick embryo during organogenesis. Löwkvist, B., Emanuelsson, H., Persson, L., Sundler, F., Lundquist, A., Heby, O. Cell Tissue Res. (1987) [Pubmed]
  21. Ornithine decarboxylase: haplotype structure and trait associations in White Leghorn chickens. Parsanejad, R., Praslickova, D., Zadworny, D., Kuhnlein, U. Poult. Sci. (2004) [Pubmed]
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