High impact information on Odc1

• Ornithine decarboxylase (L-ornithine carboxy-lase, EC 4.1.1.17) and S-adenosyl-methionine decarboxylase (S-adenosyl-L-methionine carboxy-lase, EC 4.1.1.50) were assayed in Drosophilia melanogaster larvae [1].
• Isolation and characterization of the Drosophila ornithine decarboxylase locus: evidence for the presence of two transcribed ODC genes in the Drosophila genome [2].
• Both ODC genes were assigned by in situ hybridization analysis to position 44A on the right arm of the second chromosome [2].
• Juvenile hormone stimulation of ornithine decarboxylase activity during vitellogenesis in Drosophila melanogaster [3].
• Elevated ODC activity appeared to be localized in the adult fat body [3].

Biological context of Odc1

• During embryogenesis, ODC activity remained undetectable until just prior to hatching, when a large increase was detected [3].
• Ju-myo protein did not exert any influence on cell proliferation, as reflected by ornithine decarboxylase (ODC) or spermidine/spermine N1-acetyltransferase (SAT) activity and BrdU labeling [4].

Analytical, diagnostic and therapeutic context of Odc1

• Sequence analysis of the resulting DNA products confirmed their identity as ODC fragments [2].
• The polymerase chain reaction (PCR) was used to isolate two Drosophila ornithine decarboxylase (ODC) genes [2].

References