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Gene Review

FCRL3  -  Fc receptor-like 3

Homo sapiens

Synonyms: CD307c, FCRH3, Fc receptor homolog 3, Fc receptor-like protein 3, FcR-like protein 3, ...
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Disease relevance of FCRL3


High impact information on FCRL3


Biological context of FCRL3

  • Our aim was to study the role of two promoter SNPs of the FCRL3 gene (-169A>G, rs7528684 and -110C>T, rs11264799) in patients with IBD and their interaction with HLA-DRB1 and CARD15 in patients with UC and CD, respectively [2].
  • Sequence alignment with the genomic database revealed that the SPAP2 gene contains 16 exons and is localized at chromosome 1q21 [8].
  • A case-control study showed that the strongest evidence of the association was derived from a polymorphism in the promoter region of FCRL3, which has a regulatory effect on the expression of the gene [9].

Anatomical context of FCRL3


Associations of FCRL3 with chemical compounds

  • The extracellular portion of SPAP2 contains six immunoglobulin-like domains and its intracellular segment has two immunoreceptor tyrosine-based activation motifs (ITAMs) and two immunoreceptor tyrosine-based inhibition motifs (ITIMs) [8].

Other interactions of FCRL3


Analytical, diagnostic and therapeutic context of FCRL3


  1. Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. Simmonds, M.J., Heward, J.M., Carr-Smith, J., Foxall, H., Franklyn, J.A., Gough, S.C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  2. Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD. Martínez, A., Núñez, C., Martín, M.C., Mendoza, J.L., Taxonera, C., Díaz-Rubio, M., de la Concha, E.G., Urcelay, E. Tissue Antigens (2007) [Pubmed]
  3. Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients. Umemura, T., Ota, M., Hamano, H., Katsuyama, Y., Kiyosawa, K., Kawa, S. Gut (2006) [Pubmed]
  4. Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association. Owen, C.J., Kelly, H., Eden, J.A., Merriman, M.E., Pearce, S.H., Merriman, T.R. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  5. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Kochi, Y., Yamada, R., Suzuki, A., Harley, J.B., Shirasawa, S., Sawada, T., Bae, S.C., Tokuhiro, S., Chang, X., Sekine, A., Takahashi, A., Tsunoda, T., Ohnishi, Y., Kaufman, K.M., Kang, C.P., Kang, C., Otsubo, S., Yumura, W., Mimori, A., Koike, T., Nakamura, Y., Sasazuki, T., Yamamoto, K. Nat. Genet. (2005) [Pubmed]
  6. Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. Newman, W.G., Zhang, Q., Liu, X., Walker, E., Ternan, H., Owen, J., Johnson, B., Greer, W., Mosher, D.P., Maksymowych, W.P., Bykerk, V.P., Keystone, E.C., Amos, C.I., Siminovitch, K.A. Arthritis Rheum. (2006) [Pubmed]
  7. The functional -169T-->C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans. Hu, X., Chang, M., Saiki, R.K., Cargill, M.A., Begovich, A.B., Ardlie, K.G., Criswell, L.A., Seldin, M.F., Amos, C.I., Gregersen, P.K., Kastner, D.L., Remmers, E.F. Arthritis Rheum. (2006) [Pubmed]
  8. SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Xu, M.J., Zhao, R., Cao, H., Zhao, Z.J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. Supportive evidence for a genetic association of the FCRL3 promoter polymorphism with rheumatoid arthritis. Ikari, K., Momohara, S., Nakamura, T., Hara, M., Yamanaka, H., Tomatsu, T., Kamatani, N. Ann. Rheum. Dis. (2006) [Pubmed]
  10. Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? Eyre, S., Bowes, J., Potter, C., Worthington, J., Barton, A. Arthritis Res. Ther. (2006) [Pubmed]
  11. Polymorphisms of the FCRL3 gene in a Spanish population of systemic lupus erythematosus patients. Sanchez, E., Callejas, J.L., Sabio, J.M., de Haro, M., Camps, M., de Ramón, E., García-Hernández, F.J., Koeleman, B., Martín, J., González-Escribano, M.F. Rheumatology (Oxford, England) (2006) [Pubmed]
  12. The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans. Choi, C.B., Kang, C.P., Seong, S.S., Bae, S.C., Kang, C. Arthritis Rheum. (2006) [Pubmed]
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