Disease relevance of FCRL3

• Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease [1].
• The Fc receptor-like 3 gene (FCRL3) maps to the human chromosome 1q21-22 and certain single nucleotide polymorphisms (SNPs) in its promoter have been associated with some autoimmune diseases [2].
• Genetic association of Fc receptor-like 3 polymorphisms with autoimmune pancreatitis in Japanese patients [3].
• The FCRL3 haplotype that is associated with AAD in Caucasians appears to be protective for autoimmune diseases in the Japanese population, demonstrating that this haplotype is unlikely to contain a single primary etiological allele for autoimmunity [4].

High impact information on FCRL3

• We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype [5].
• FCRL3 may therefore have a pivotal role in autoimmunity [5].
• A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities [5].
• Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population [6].
• The functional -169T-->C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans [7].

Biological context of FCRL3

• Our aim was to study the role of two promoter SNPs of the FCRL3 gene (-169A>G, rs7528684 and -110C>T, rs11264799) in patients with IBD and their interaction with HLA-DRB1 and CARD15 in patients with UC and CD, respectively [2].
• Sequence alignment with the genomic database revealed that the SPAP2 gene contains 16 exons and is localized at chromosome 1q21 [8].
• A case-control study showed that the strongest evidence of the association was derived from a polymorphism in the promoter region of FCRL3, which has a regulatory effect on the expression of the gene [9].

Anatomical context of FCRL3

• PCR analyses demonstrated that SPAP2 mRNA is expressed in restricted human tissues including the kidney, salivary gland, adrenal gland, uterus, and bone marrow [8].

Associations of FCRL3 with chemical compounds

• The extracellular portion of SPAP2 contains six immunoglobulin-like domains and its intracellular segment has two immunoreceptor tyrosine-based activation motifs (ITAMs) and two immunoreceptor tyrosine-based inhibition motifs (ITIMs) [8].

Other interactions of FCRL3

• The aim of this study was to investigate association of the FCRL3 gene with RA in UK subjects [10].
• Polymorphisms of the FCRL3 gene in a Spanish population of systemic lupus erythematosus patients [11].

Analytical, diagnostic and therapeutic context of FCRL3

• The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans [12].

References