Gene Review:
PTPN22 - protein tyrosine phosphatase, non-receptor...
Homo sapiens
Synonyms:
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, LYP, LYP1, LYP2, LyP, ...
Gregersen,
Jeffery,
Lasbleiz,
Radstake,
Chang,
Vaz,
Van Riel,
Gishizky,
Dieudé,
van de Putte,
Catanese,
Bardin,
Taniyama,
Tozaki,
Hill,
Alves,
Rat,
Donn,
Tomita,
Begovich,
Chang,
Cornélis,
Chokkalingam,
Worthington,
Barrera,
Prum,
Saiki,
Pierlot,
Huang,
Bruce,
Ban,
Garnier,
Kastner,
Zozulya,
Lemaire,
Carlton,
Smith,
Kunos,
Glikmans,
Westhovens,
Honigberg,
Chan,
Ward,
Alexander,
Dequeker,
Gregersen,
Osei-Hyiaman,
Lopes-Vaz,
Griffiths,
Liu,
McAllister,
Gong,
Dausset,
Silman,
Thomson,
Seldin,
Zhou,
Leong,
Lu,
Hinks,
Ardlie,
Remmers,
Fernandes,
Jallal,
Balsa,
Hawkins,
P. Dieudé,
M. Guedj,
J. Wipff,
J. Avouac,
E. Hachulla,
E. Diot,
B. Granel,
J. Sibilia,
J. Cabane,
O. Meyer,
L. Mouthon,
A. Kahan,
C. Boileau,
Y. Allanore,
Criswell,
Barton,
Pascual-Salcedo,
Wang,
Lee,
John,
Batliwalla,
Ban,
Kim,
Migliorini,
Sninsky,
Amos,
Petit-Teixeira,
Spoerke,
Razdan,
Conn,
Harvey-White,
Bombardieri,
Michou,
Huang,
Garcia,
Schrodi,
- Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene. Michou, L., Lasbleiz, S., Rat, A.C., Migliorini, P., Balsa, A., Westhovens, R., Barrera, P., Alves, H., Pierlot, C., Glikmans, E., Garnier, S., Dausset, J., Vaz, C., Fernandes, M., Petit-Teixeira, E., Lemaire, I., Pascual-Salcedo, D., Bombardieri, S., Dequeker, J., Radstake, T.R., Van Riel, P., van de Putte, L., Lopes-Vaz, A., Prum, B., Bardin, T., Dieudé, P., Cornélis, F. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Hinks, A., Barton, A., John, S., Bruce, I., Hawkins, C., Griffiths, C.E., Donn, R., Thomson, W., Silman, A., Worthington, J. Arthritis Rheum. (2005)
- Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations. van Oene, M., Wintle, R.F., Liu, X., Yazdanpanah, M., Gu, X., Newman, B., Kwan, A., Johnson, B., Owen, J., Greer, W., Mosher, D., Maksymowych, W., Keystone, E., Rubin, L.A., Amos, C.I., Siminovitch, K.A. Arthritis Rheum. (2005)
- Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Vang, T., Congia, M., Macis, M.D., Musumeci, L., Orrú, V., Zavattari, P., Nika, K., Tautz, L., Taskén, K., Cucca, F., Mustelin, T., Bottini, N. Nat. Genet. (2005)
- Association of PTPN22 haplotypes with Graves' disease. Heward, J.M., Brand, O.J., Barrett, J.C., Carr-Smith, J.D., Franklyn, J.A., Gough, S.C. J. Clin. Endocrinol. Metab. (2007)
- The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis. Dieudé, P., Guedj, M., Wipff, J., Avouac, J., Hachulla, E., Diot, E., Granel, B., Sibilia, J., Cabane, J., Meyer, O., Mouthon, L., Kahan, A., Boileau, C., Allanore, Y. Arthritis Rheum. (2008)
- Gaining insight into PTPN22 and autoimmunity. Gregersen, P.K. Nat. Genet. (2005)
- PTPN22 and autoimmune disease. Siminovitch, K.A. Nat. Genet. (2004)
- A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J., Meloni, G.F., Lucarelli, P., Pellecchia, M., Eisenbarth, G.S., Comings, D., Mustelin, T. Nat. Genet. (2004)
- Genetic susceptibility to type 1 diabetes. Maier, L.M., Wicker, L.S. Curr. Opin. Immunol. (2005)
- A biosynthetic pathway for anandamide. Liu, J., Wang, L., Harvey-White, J., Osei-Hyiaman, D., Razdan, R., Gong, Q., Chan, A.C., Zhou, Z., Huang, B.X., Kim, H.Y., Kunos, G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese. Ban, Y., Tozaki, T., Taniyama, M., Tomita, M., Ban, Y. Thyroid (2005)
- A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Begovich, A.B., Carlton, V.E., Honigberg, L.A., Schrodi, S.J., Chokkalingam, A.P., Alexander, H.C., Ardlie, K.G., Huang, Q., Smith, A.M., Spoerke, J.M., Conn, M.T., Chang, M., Chang, S.Y., Saiki, R.K., Catanese, J.J., Leong, D.U., Garcia, V.E., McAllister, L.B., Jeffery, D.A., Lee, A.T., Batliwalla, F., Remmers, E., Criswell, L.A., Seldin, M.F., Kastner, D.L., Amos, C.I., Sninsky, J.J., Gregersen, P.K. Am. J. Hum. Genet. (2004)
- PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Carlton, V.E., Hu, X., Chokkalingam, A.P., Schrodi, S.J., Brandon, R., Alexander, H.C., Chang, M., Catanese, J.J., Leong, D.U., Ardlie, K.G., Kastner, D.L., Seldin, M.F., Criswell, L.A., Gregersen, P.K., Beasley, E., Thomson, G., Amos, C.I., Begovich, A.B. Am. J. Hum. Genet. (2005)
- Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond. Gregersen, P.K. Immunol. Rev. (2005)
- Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Kyogoku, C., Langefeld, C.D., Ortmann, W.A., Lee, A., Selby, S., Carlton, V.E., Chang, M., Ramos, P., Baechler, E.C., Batliwalla, F.M., Novitzke, J., Williams, A.H., Gillett, C., Rodine, P., Graham, R.R., Ardlie, K.G., Gaffney, P.M., Moser, K.L., Petri, M., Begovich, A.B., Gregersen, P.K., Behrens, T.W. Am. J. Hum. Genet. (2004)
- Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. Wu, H., Cantor, R.M., Graham, D.S., Lingren, C.M., Farwell, L., Jager, P.L., Bottini, N., Grossman, J.M., Wallace, D.J., Hahn, B.H., Julkunen, H., Hebert, L.A., Rovin, B.H., Birmingham, D.J., Rioux, J.D., Yu, C.Y., Kere, J., Vyse, T.J., Tsao, B.P. Arthritis Rheum. (2005)
- Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis. Gonzalez-Gay, M.A., Oliver, J., Orozco, G., Garcia-Porrua, C., Lopez-Nevot, M.A., Martin, J. J. Rheumatol. (2005)
- The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1. Reddy, M.V., Johansson, M., Sturfelt, G., Jönsen, A., Gunnarsson, I., Svenungsson, E., Rantapää-Dahlqvist, S., Alarcón-Riquelme, M.E. Genes Immun. (2005)
- Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients. Hüffmeier, U., Steffens, M., Burkhardt, H., Lascorz, J., Schürmeier-Horst, F., Ständer, M., Kelsch, R., Baumann, C., Küster, W., Mössner, R., Reich, K., Wienker, T.F., Traupe, H., Reis, A. J. Med. Genet. (2006)
- Carbomethoxychlorocarbene: spectroscopy, theory, chemistry and kinetics. Likhotvorik, I., Zhu, Z., Tae, E.L., Tippmann, E., Hill, B.T., Platz, M.S. J. Am. Chem. Soc. (2001)
- The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. Velaga, M.R., Wilson, V., Jennings, C.E., Owen, C.J., Herington, S., Donaldson, P.T., Ball, S.G., James, R.A., Quinton, R., Perros, P., Pearce, S.H. J. Clin. Endocrinol. Metab. (2004)
- Mechanism of Reppe's nickel-catalyzed ethyne tetramerization to cyclooctatetraene: a DFT study. Straub, B.F., Gollub, C. Chemistry (Weinheim an der Bergstrasse, Germany) (2004)
- The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Hill, R.J., Zozulya, S., Lu, Y.L., Ward, K., Gishizky, M., Jallal, B. Exp. Hematol. (2002)
- A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Cantón, I., Akhtar, S., Gavalas, N.G., Gawkrodger, D.J., Blomhoff, A., Watson, P.F., Weetman, A.P., Kemp, E.H. Genes Immun. (2005)
- Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Plenge, R.M., Padyukov, L., Remmers, E.F., Purcell, S., Lee, A.T., Karlson, E.W., Wolfe, F., Kastner, D.L., Alfredsson, L., Altshuler, D., Gregersen, P.K., Klareskog, L., Rioux, J.D. Am. J. Hum. Genet. (2005)
- Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Orozco, G., Sánchez, E., González-Gay, M.A., López-Nevot, M.A., Torres, B., Cáliz, R., Ortego-Centeno, N., Jiménez-Alonso, J., Pascual-Salcedo, D., Balsa, A., de Pablo, R., Nuñez-Roldan, A., González-Escribano, M.F., Martín, J. Arthritis Rheum. (2005)
- Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Cohen, S., Dadi, H., Shaoul, E., Sharfe, N., Roifman, C.M. Blood (1999)
- Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Concannon, P., Erlich, H.A., Julier, C., Morahan, G., Nerup, J., Pociot, F., Todd, J.A., Rich, S.S. Diabetes (2005)
- The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population. Fedetz, M., Matesanz, F., Caro-Maldonado, A., Smirnov, I.I., Chvorostinka, V.N., Moiseenko, T.A., Alcina, A. Tissue Antigens (2006)
- Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Bekkenk, M.W., Geelen, F.A., van Voorst Vader, P.C., Heule, F., Geerts, M.L., van Vloten, W.A., Meijer, C.J., Willemze, R. Blood (2000)