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Gene Review

Crisp3  -  cysteine-rich secretory protein 3

Mus musculus

Synonyms: Acidic epididymal glycoprotein 2, Aeg-2, Aeg2, CRISP-3, CRS3, ...
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Disease relevance of Crisp3


High impact information on Crisp3


Biological context of Crisp3

  • Over 800 bp of CRISP-3 promoter region were determined and two regions almost exactly matching the androgen-responsive element consensus RGWACANNNTGTWCY detected [1].
  • In addition, the cDNA coding for the new related CRISP-3, which shares 77% amino acid identity with CRISP-1, was isolated from a salivary gland cDNA library [4].
  • The equine TPX1 gene consists of ten exons spanning 18 kb while the AEG2 gene consists of eight exons that are spread over 24 kb [5].
  • In this report, the cloning and DNA sequence of 137 kb of horse genomic DNA from equine chromosome 20q22 containing the closely linked equine TPX1 and AEG2 genes are described [5].

Anatomical context of Crisp3

  • The second, more abundant transcript, Aeg-2, had a sequence similar to, but distinct from, that of Aeg-1, and was not detectable in the epididymis [6].
  • In the present study, we show that the mouse submandibular gland (SMG) expresses two genes designated Aeg-1 and Aeg-2 [6].
  • CRISP-1 and CRISP-2 transcripts were detected as early as 22 days after birth in the epididymis and testis, respectively, whereas CRISP-3 mRNA was visible only from day 30 in the salivary gland [7].
  • Here, we present the identification and characterization of a further gene, coding for cysteine-rich secreted protein 3 (CRISP-3), whose expression in B cells is regulated by Oct2 [2].

Associations of Crisp3 with chemical compounds

  • CRISP-1 and CRISP-3 RNA levels were significantly increased, and these effects were prevented by a concomitant treatment with the antiandrogen flutamide [7].

Analytical, diagnostic and therapeutic context of Crisp3


  1. Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-3 (CRISP-3) gene. Schwidetzky, U., Haendler, B., Schleuning, W.D. Biochem. J. (1995) [Pubmed]
  2. CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2. Pfisterer, P., König, H., Hess, J., Lipowsky, G., Haendler, B., Schleuning, W.D., Wirth, T. Mol. Cell. Biol. (1996) [Pubmed]
  3. Expression of transcripts for cysteine-rich secretory proteins (CRISPs) in the murine lacrimal gland. Haendler, B., Toda, I., Sullivan, D.A., Schleuning, W.D. J. Cell. Physiol. (1999) [Pubmed]
  4. Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG) and the novel related CRISP-3 are expressed under androgen control in the mouse salivary gland. Haendler, B., Krätzschmar, J., Theuring, F., Schleuning, W.D. Endocrinology (1993) [Pubmed]
  5. Molecular characterization of the equine testis-specific protein 1 (TPX1) and acidic epididymal glycoprotein 2 (AEG2) genes encoding members of the cysteine-rich secretory protein (CRISP) family. Giese, A., Jude, R., Kuiper, H., Raudsepp, T., Piumi, F., Schambony, A., Guérin, G., Chowdhary, B.P., Distl, O., Töpfer-Petersen, E., Leeb, T. Gene (2002) [Pubmed]
  6. Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mizuki, N., Kasahara, M. Mol. Cell. Endocrinol. (1992) [Pubmed]
  7. Differential androgen regulation of the murine genes for cysteine-rich secretory proteins (CRISP). Haendler, B., Habenicht, U.F., Schwidetzky, U., Schüttke, I., Schleuning, W.D. Eur. J. Biochem. (1997) [Pubmed]
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