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Gene Review

Crisp1  -  cysteine-rich secretory protein 1

Rattus norvegicus

Synonyms: 32 kDa epididymal protein, Acidic epididymal glycoprotein, Aeg, Crisp-1, Cysteine-rich secretory protein 1, ...
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Disease relevance of Crisp1


Psychiatry related information on Crisp1


High impact information on Crisp1


Chemical compound and disease context of Crisp1

  • The acylated form of protein D of Haemophilus influenzae is more immunogenic than the nonacylated form and elicits an adjuvant effect when it is used as a carrier conjugated to polyribosyl ribitol phosphate [5].
  • Captopril treatment caused total regression of hypertension and LV hypertrophy and decreased both content and concentration of DNA and RNA, as well as the contents of MP, CP and SCP v the L -NAME group [11].
  • A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity [12].

Biological context of Crisp1

  • Amino acid sequence homology of AEG with metal-binding domains of several proteins suggests that AEG is a metalloprotein [13].
  • Two classes of AEG cDNA, approximately 1500 base pairs (bp) and 950 bp in length, differed by 538 bp in the 3'-untranslated region and by four single nucleotide mismatches, one of which was in the coding region [13].
  • Screening of a rat epididymal cDNA library with affinity-purified AEG antiserum yielded cDNA for AEG [13].
  • Sterol carrier protein (SCP) is a highly abundant, ubiquitous, low molecular weight protein that has a rapid turnover and multifunctional roles in lipid metabolism and transport [14].
  • The proliferative potential of cultured epididymal cells obtained from pubertal and old adult donors can be documented by [3H]thymidine labeling and mitotic indices without significant loss of gene expression for acidic epididymal glycoprotein [15].

Anatomical context of Crisp1


Associations of Crisp1 with chemical compounds


Other interactions of Crisp1


Analytical, diagnostic and therapeutic context of Crisp1


  1. Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. I. Lesions associated with mesangial IgM deposits. Bolton, W.K., Benton, F.R., Maclay, J.G., Sturgill, B.C. Am. J. Pathol. (1976) [Pubmed]
  2. Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function. Alcorn, J.F., Wright, J.R. J. Biol. Chem. (2004) [Pubmed]
  3. Reduced sialylation of podocalyxin--the major sialoprotein of the rat kidney glomerulus--in aminonucleoside nephrosis. Kerjaschki, D., Vernillo, A.T., Farquhar, M.G. Am. J. Pathol. (1985) [Pubmed]
  4. Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo. Zhang, L., Ikegami, M., Dey, C.R., Korfhagen, T.R., Whitsett, J.A. J. Biol. Chem. (2002) [Pubmed]
  5. The acylated form of protein D of Haemophilus influenzae is more immunogenic than the nonacylated form and elicits an adjuvant effect when it is used as a carrier conjugated to polyribosyl ribitol phosphate. Akkoyunlu, M., Melhus, A., Capiau, C., van Opstal, O., Forsgren, A. Infect. Immun. (1997) [Pubmed]
  6. Hormonal triggering of the diurnal variation of sterol carrier protein. Hargis, P.S., Olson, C.D., Clarke, S.D., Dempsey, M.E. J. Biol. Chem. (1986) [Pubmed]
  7. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. Takeda, T., McQuistan, T., Orlando, R.A., Farquhar, M.G. J. Clin. Invest. (2001) [Pubmed]
  8. Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages. O'Riordan, D.M., Standing, J.E., Kwon, K.Y., Chang, D., Crouch, E.C., Limper, A.H. J. Clin. Invest. (1995) [Pubmed]
  9. Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells. Kerjaschki, D., Poczewski, H., Dekan, G., Horvat, R., Balzar, E., Kraft, N., Atkins, R.C. J. Clin. Invest. (1986) [Pubmed]
  10. Endothelial cell membranes contain podocalyxin--the major sialoprotein of visceral glomerular epithelial cells. Horvat, R., Hovorka, A., Dekan, G., Poczewski, H., Kerjaschki, D. J. Cell Biol. (1986) [Pubmed]
  11. Regression of chronic L -NAME-treatment-induced left ventricular hypertrophy: effect of captopril. Bernátová, I., Pechánová, O., Pelouch, V., Simko, F. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  12. A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity. Taylor, M.D., Van Dyke, K., Bowman, L.L., Miles, P.R., Hubbs, A.F., Mason, R.J., Shannon, K., Reasor, M.J. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  13. Molecular cloning of complementary deoxyribonucleic acid for an androgen-regulated epididymal protein: sequence homology with metalloproteins. Charest, N.J., Joseph, D.R., Wilson, E.M., French, F.S. Mol. Endocrinol. (1988) [Pubmed]
  14. Intramitochondrial movement of adrenal sterol carrier protein with cholesterol in response to corticotropin. Conneely, O.M., Headon, D.R., Olson, C.D., Ungar, F., Dempsey, M.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  15. Isolation, culture, and immunocytochemical characterization of epididymal epithelial cells from pubertal and adult rats. Kierszenbaum, A.L., Lea, O., Petrusz, P., French, F.S., Tres, L.L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. Biogenesis of microsomal membrane glycoproteins in rat liver. I. Presence of glycoproteins in microsomes and cytosol. Autuori, F., Svensson, H., Dallner, G. J. Cell Biol. (1975) [Pubmed]
  17. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Oldberg, A., Franzén, A., Heinegård, D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  18. Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development. Baba, O., Qin, C., Brunn, J.C., Wygant, J.N., McIntyre, B.W., Butler, W.T. Matrix Biol. (2004) [Pubmed]
  19. Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A. Head, J.F., Mealy, T.R., McCormack, F.X., Seaton, B.A. J. Biol. Chem. (2003) [Pubmed]
  20. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Schmidt, C.R., Gi, Y.J., Patel, T.A., Coffey, R.J., Beauchamp, R.D., Pearson, A.S. Surgery (2005) [Pubmed]
  21. Gene expression in the aging brown Norway rat epididymis. Viger, R.S., Robaire, B. J. Androl. (1995) [Pubmed]
  22. Biogenesis of plasma membrane glycoproteins. Purification and properties of two rat liver plasma membrane glycoproteins. Elovson, J. J. Biol. Chem. (1980) [Pubmed]
  23. Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage. Kuan, S.F., Rust, K., Crouch, E. J. Clin. Invest. (1992) [Pubmed]
  24. Glomerular anionic site distribution in nonproteinuric rats. A computer-assisted morphometric analysis. Pilia, P.A., Swain, R.P., Williams, A.V., Loadholt, C.B., Ainsworth, S.K. Am. J. Pathol. (1985) [Pubmed]
  25. Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody. Evidence that 59-kDa BSP may be the rat counterpart of human alpha 2-HS glycoprotein and is synthesized by both hepatocytes and osteoblasts. Ohnishi, T., Arakaki, N., Nakamura, O., Hirono, S., Daikuhara, Y. J. Biol. Chem. (1991) [Pubmed]
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