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Gene Review

Crisp1  -  cysteine-rich secretory protein 1

Mus musculus

Synonyms: AW324342, Acidic epididymal glycoprotein 1, Aeg-1, Aeg1, CRISP-1, ...
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Disease relevance of Crisp1

  • We have now isolated and characterized overlapping phage clones covering the entire length of the CRISP-1 gene [1].
  • Further studies will reveal to what extent the absence or the non-functionality of SCP1 contributes to male infertility [2].
  • NW-BR-2 is identical to the CT antigen SCP-1, initially isolated by SEREX analysis of renal cancer [3].
  • Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum [3].

High impact information on Crisp1

  • The protein shares homology with the mammalian cysteine-rich secretory protein (CRISP) family that includes testes-specific spermatocyte protein 1, a cell adhesion protein which links spermatocytes to Seritoli cells, and acidic epididymal glycoproteins that bind to sperm and have been implicated in sperm-egg fusion [4].
  • The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling [5].
  • The first member of the cysteine-rich secretory protein (CRISP) family was described by our laboratory in the rat epididymis, and it is known as DE or CRISP-1 [6].
  • The interesting finding that the binding site of DE resides in an evolutionarily conserved region of the molecule provides novel information on the molecular mechanisms underlying CRISP-1 function in gamete fusion with important implications on the structure-function relationship of other members of the widely distributed CRISP family [6].
  • To test this possibility we used the yeast two-hybrid system and found that the N-terminal end of the SCP1 protein indeed strongly interacted with itself, but not with other protein domains tested [7].

Biological context of Crisp1


Anatomical context of Crisp1


Associations of Crisp1 with chemical compounds


Regulatory relationships of Crisp1


Other interactions of Crisp1


Analytical, diagnostic and therapeutic context of Crisp1


  1. Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-1 (CRISP-1) gene. Schwidetzky, U., Schleuning, W.D., Haendler, B. Biochem. J. (1997) [Pubmed]
  2. Presence of synaptonemal complex protein 1 transversal filament-like protein in human primary spermatocytes. Pousette, A., Leijonhufvud, P., Arver, S., Kvist, U., Pelttari, J., Höög, C. Hum. Reprod. (1997) [Pubmed]
  3. Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum. Jäger, D., Unkelbach, M., Frei, C., Bert, F., Scanlan, M.J., Jäger, E., Old, L.J., Chen, Y.T., Knuth, A. Cancer Immun. (2002) [Pubmed]
  4. Allurin, a 21-kDa sperm chemoattractant from Xenopus egg jelly, is related to mammalian sperm-binding proteins. Olson, J.H., Xiang, X., Ziegert, T., Kittelson, A., Rawls, A., Bieber, A.L., Chandler, D.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. Gibbs, G.M., Scanlon, M.J., Swarbrick, J., Curtis, S., Gallant, E., Dulhunty, A.F., O'Bryan, M.K. J. Biol. Chem. (2006) [Pubmed]
  6. Sperm protein "DE" mediates gamete fusion through an evolutionarily conserved site of the CRISP family. Ellerman, D.A., Cohen, D.J., Da Ros, V.G., Morgenfeld, M.M., Busso, D., Cuasnicú, P.S. Dev. Biol. (2006) [Pubmed]
  7. Localization of the N-terminus of SCP1 to the central element of the synaptonemal complex and evidence for direct interactions between the N-termini of SCP1 molecules organized head-to-head. Liu, J.G., Yuan, L., Brundell, E., Björkroth, B., Daneholt, B., Höög, C. Exp. Cell Res. (1996) [Pubmed]
  8. Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mizuki, N., Kasahara, M. Mol. Cell. Endocrinol. (1992) [Pubmed]
  9. Autoantigen 1 of the guinea pig sperm acrosome is the homologue of mouse Tpx-1 and human TPX1 and is a member of the cysteine-rich secretory protein (CRISP) family. Foster, J.A., Gerton, G.L. Mol. Reprod. Dev. (1996) [Pubmed]
  10. Differential androgen regulation of the murine genes for cysteine-rich secretory proteins (CRISP). Haendler, B., Habenicht, U.F., Schwidetzky, U., Schüttke, I., Schleuning, W.D. Eur. J. Biochem. (1997) [Pubmed]
  11. Expression of transcripts for cysteine-rich secretory proteins (CRISPs) in the murine lacrimal gland. Haendler, B., Toda, I., Sullivan, D.A., Schleuning, W.D. J. Cell. Physiol. (1999) [Pubmed]
  12. Evidence for the Involvement of Testicular Protein CRISP2 in Mouse Sperm-Egg Fusion. Busso, D., Goldweic, N.M., Hayashi, M., Kasahara, M., Cuasnicú, P.S. Biol. Reprod. (2007) [Pubmed]
  13. SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. Kjeldsen, L., Cowland, J.B., Johnsen, A.H., Borregaard, N. FEBS Lett. (1996) [Pubmed]
  14. Mouse androgen-dependent epididymal glycoprotein CRISP-1 (DE/AEG): isolation, biochemical characterization, and expression in recombinant form. Eberspaecher, U., Roosterman, D., Krätzschmar, J., Haendler, B., Habenicht, U.F., Becker, A., Quensel, C., Petri, T., Schleuning, W.D., Donner, P. Mol. Reprod. Dev. (1995) [Pubmed]
  15. Epididymal cysteine-rich secretory protein 1 encoding gene is expressed in murine hair follicles and downregulated in mice overexpressing Hoxc13. Peterson, R.L., Tkatchenko, T.V., Pruett, N.D., Potter, C.S., Jacobs, D.F., Awgulewitsch, A. J. Investig. Dermatol. Symp. Proc. (2005) [Pubmed]
  16. Evaluation of the 5'-flanking regions of murine glutathione peroxidase five and cysteine-rich secretory protein-1 genes for directing transgene expression in mouse epididymis. Lahti, P.P., Shariatmadari, R., Penttinen, J.K., Drevet, J.R., Haendler, B., Vierula, M., Parvinen, M., Huhtaniemi, I.T., Poutanen, M. Biol. Reprod. (2001) [Pubmed]
  17. Cloning and characterization of the rat Crisp-1 gene. Klemme, L.M., Roberts, K.P., Hoffman, L.B., Ensrud, K.M., Siiteri, J.E., Hamilton, D.W. Gene (1999) [Pubmed]
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