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Gene Review

Sh3gl2  -  SH3-domain GRB2-like 2

Rattus norvegicus

Synonyms: Endophilin-1, Endophilin-A1, SH3 domain protein 2A, SH3 domain-containing GRB2-like protein 2, SH3p4, ...
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High impact information on Sh3gl2


Biological context of Sh3gl2


Anatomical context of Sh3gl2

  • Differential expression of endophilin 1 and 2 dimers at central nervous system synapses [7].
  • We show here that antibody-mediated disruption of endophilin function in a tonically stimulated synapse leads to a block in the invagination of clathrin-coated pits adjacent to the active zone and therefore to a block of synaptic vesicle recycling [3].

Associations of Sh3gl2 with chemical compounds


Other interactions of Sh3gl2

  • Preloading of dynamin-1 PRD with the amphiphysin-SH3 domain partially occluded binding of the endophilin-SH3 domain, indicating overlap between the binding sites in the C terminus, but endophilin was still able to interact with the high affinity N-terminal site [9].

Analytical, diagnostic and therapeutic context of Sh3gl2


  1. Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Anggono, V., Smillie, K.J., Graham, M.E., Valova, V.A., Cousin, M.A., Robinson, P.J. Nat. Neurosci. (2006) [Pubmed]
  2. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Voglmaier, S.M., Kam, K., Yang, H., Fortin, D.L., Hua, Z., Nicoll, R.A., Edwards, R.H. Neuron (2006) [Pubmed]
  3. Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis. Ringstad, N., Gad, H., Löw, P., Di Paolo, G., Brodin, L., Shupliakov, O., De Camilli, P. Neuron (1999) [Pubmed]
  4. Inhibitory role of endophilin 3 in receptor-mediated endocytosis. Sugiura, H., Iwata, K., Matsuoka, M., Hayashi, H., Takemiya, T., Yasuda, S., Ichikawa, M., Yamauchi, T., Mehlen, P., Haga, T., Yamagata, K. J. Biol. Chem. (2004) [Pubmed]
  5. Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Lee, S.Y., Wenk, M.R., Kim, Y., Nairn, A.C., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor. Szaszák, M., Gáborik, Z., Turu, G., McPherson, P.S., Clark, A.J., Catt, K.J., Hunyady, L. J. Biol. Chem. (2002) [Pubmed]
  7. Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. Ringstad, N., Nemoto, Y., De Camilli, P. J. Biol. Chem. (2001) [Pubmed]
  8. Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis. Vinatier, J., Herzog, E., Plamont, M.A., Wojcik, S.M., Schmidt, A., Brose, N., Daviet, L., El Mestikawy, S., Giros, B. J. Neurochem. (2006) [Pubmed]
  9. Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation. Solomaha, E., Szeto, F.L., Yousef, M.A., Palfrey, H.C. J. Biol. Chem. (2005) [Pubmed]
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