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Gene Review

Anxa11  -  annexin A11

Mus musculus

Synonyms: A830099O17Rik, Annexin A11, Annexin XI, Annexin-11, Anx11, ...
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High impact information on Anxa11


Biological context of Anxa11

  • Knowledge of the mouse cDNA sequence and genetic map location will assist in the analysis of genomic organization and expression and provide a useful animal model to investigate gene function and hereditary phenotype for annexin XI [3].
  • Mouse annexin XI (anx11)2 was cloned from a macrophage cDNA library and characterized by genetic linkage mapping, DNA sequencing, and structural comparison with other annexins [3].
  • Linkage mapping of mouse Anx8 to the centromeric region of Chromosome (Chr) 14 placed it in a more distal homology group from previously mapped Anx7 and Anx11 [4].

Anatomical context of Anxa11


Other interactions of Anxa11

  • Although annexin VIII also derived from annexin XI, the evolutionary branching order, gene separation times, and mapping results indicated that it was probably a subsequent duplication product of annexin IV about 300 million years ago [4].

Analytical, diagnostic and therapeutic context of Anxa11


  1. Structural and functional characterization of recombinant mouse annexin A11: influence of calcium binding. Lecona, E., Turnay, J., Olmo, N., Guzmán-Aránguez, A., Morgan, R.O., Fernandez, M.P., Lizarbe, M.A. Biochem. J. (2003) [Pubmed]
  2. Annexin XI co-localises with calcyclin in proliferating cells of the embryonic mouse testis. Williams, L.H., McClive, P.J., Van Den Bergen, J.A., Sinclair, A.H. Dev. Dyn. (2005) [Pubmed]
  3. Sequence and chromosomal localization of mouse annexin XI. Fernandez, M.P., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Morgan, R.O. Genomics (1996) [Pubmed]
  4. The genetic origin of mouse annexin VIII. Fernández, M.P., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Morgan, R.O. Mamm. Genome (1998) [Pubmed]
  5. Annexin XI may be involved in Ca2+ - or GTP-gammaS-induced insulin secretion in the pancreatic beta-cell. Iino, S., Sudo, T., Niwa, T., Fukasawa, T., Hidaka, H., Niki, I. FEBS Lett. (2000) [Pubmed]
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