The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ANXA11  -  annexin A11

Homo sapiens

Synonyms: 56 kDa autoantigen, ANX11, Annexin A11, Annexin XI, Annexin-11, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ANXA11

  • Annexin XI, a member of the Ca2+-dependent, phospholipid-binding protein family, is an example of such a protein and was used in studies to devise a strategy using human autoimmune phage display libraries to generate reagents for biological studies of conserved cellular proteins [1].
  • An IgG phage display library was generated from bone marrow of an autoimmune patient with high serum antibody titer against annexin XI, which was identified recently as an autoantigen targeted by autoantibodies in several systemic autoimmune diseases [1].
  • Autoantibodies to annexin XI were found to relate to thrombosis, but not to other clinical or laboratory features [2].
  • The other three genes were annexin XI, human HIV Rev-interacting protein Rip-1, and the human homologue of the ATP-binding arsA component of the bacterial arsenite transporter, all of which are known to be widely expressed in human tissues [3].
  • Anti-56K/annexin XI autoantibodies were found in a substantial number of patient sera (4.1-10.1%), but are rarely detected in sera from healthy controls and from patients with infectious diseases [4].

High impact information on ANXA11


Biological context of ANXA11

  • Mouse annexin A11 genomic clones were characterized by restriction analysis, Southern blotting, and DNA sequencing, and the homologous human gene (HGMW-approved gene symbol ANXA11) was deciphered from high-throughput genomic sequence with coanalysis of expressed sequence tags [6].
  • Patients' sera recognize preferentially the N-terminal region of the protein, which is specific for 56K/annexin XI and not shared by other annexins, indicating that the autoimmune response to 56K/annexin XI in these patients is specific for this annexin family member [7].
  • Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins [8].
  • Our results illuminate the multifunctional nature of human annexin XI, provide the first evidence that annexin XI associates with the mitotic spindles and might play a role in cell division, and clearly illustrate the potential of phage display-derived human autoantibodies in broader analyses of the function of highly conserved cellular proteins [1].
  • We examined the binding of CAP-50 to other Ca(2+)-binding proteins which have two of four EF-hand structures, by a co-precipitation assay with phospholipid (phosphatidylserine) [9].

Anatomical context of ANXA11


Associations of ANXA11 with chemical compounds

  • For 4-week treatments, the patients received nicardipine (NIC) 20 mg t.i.d., CAP 50 mg b.i.d., NIC plus CAP, and matched placebo [13].
  • Annexin V was found to be stable to intrinsic lung proteases in the presence of either Ca2+ or EGTA while annexin XI was found to be partially degraded by intrinsic lung proteases in the presence of EGTA [14].

Physical interactions of ANXA11

  • Among nine Ca(2+)-binding proteins (calcyclin, S-100 proteins, p11, calgizzarin, calvasculin, calmodulin and troponin C) examined, only calcyclin interacted with CAP-50 [9].

Other interactions of ANXA11


Analytical, diagnostic and therapeutic context of ANXA11


  1. Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display. Farnaes, L., Ditzel, H.J. J. Biol. Chem. (2003) [Pubmed]
  2. Determination of autoantibodies to annexin XI in systemic autoimmune diseases. Jorgensen, C.S., Levantino, G., Houen, G., Jacobsen, S., Halberg, P., Ullman, S., Khamashta, M.A., Asmussen, K., Oxholm, P., Jorgensen, M.K., van Venrooij, W.J., Wiik, A. Lupus (2000) [Pubmed]
  3. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. Güre, A.O., Altorki, N.K., Stockert, E., Scanlan, M.J., Old, L.J., Chen, Y.T. Cancer Res. (1998) [Pubmed]
  4. Prevalence and characteristics of anti-56K/annexin XI autoantibodies in systemic autoimmune diseases. Misaki, Y., Van Venrooij, W.J., Pruijn, G.J. J. Rheumatol. (1995) [Pubmed]
  5. Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI. Sjölin, C., Dahlgren, C. Blood (1996) [Pubmed]
  6. Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms. Bances, P., Fernandez, M.R., Rodriguez-Garcia, M.I., Morgan, R.O., Fernandez, M.P. Genomics (2000) [Pubmed]
  7. The 56K autoantigen is identical to human annexin XI. Misaki, Y., Pruijn, G.J., van der Kemp, A.W., van Venrooij, W.J. J. Biol. Chem. (1994) [Pubmed]
  8. Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins. Morgan, R.O., Bell, D.W., Testa, J.R., Fernandez, M.P. Genomics (1998) [Pubmed]
  9. Specific binding of CAP-50 to calcyclin. Minami, H., Tokumitsu, H., Mizutani, A., Watanabe, Y., Watanabe, M., Hidaka, H. FEBS Lett. (1992) [Pubmed]
  10. Annexins VII and XI are present in a human macrophage-like cell line. Differential translocation on FcR-mediated phagocytosis. Pittis, M.G., Garcia, R.C. J. Leukoc. Biol. (1999) [Pubmed]
  11. Calcium-dependent secretion in human neutrophils: a proteomic approach. Boussac, M., Garin, J. Electrophoresis (2000) [Pubmed]
  12. Translocation of annexin XI to neutrophil subcellular organelles. Sjölin, C., Movitz, C., Lundqvist, H., Dahlgren, C. Biochim. Biophys. Acta (1997) [Pubmed]
  13. Hemodynamic, renal, and humoral effects of the calcium entry blocker nicardipine and converting enzyme inhibitor captopril in hypertensive type II diabetic patients with nephropathy. Stornello, M., Valvo, E.V., Scapellato, L. J. Cardiovasc. Pharmacol. (1989) [Pubmed]
  14. Proteolytic signals in the primary structure of annexins. Barnes, J.A., Gomes, A.V. Mol. Cell. Biochem. (2002) [Pubmed]
  15. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner. Satoh, H., Shibata, H., Nakano, Y., Kitaura, Y., Maki, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  16. The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner. Satoh, H., Nakano, Y., Shibata, H., Maki, M. Biochim. Biophys. Acta (2002) [Pubmed]
WikiGenes - Universities