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Gene Review

Anxa7  -  annexin A7

Mus musculus

Synonyms: AI265384, AI316497, Annexin A7, Annexin VII, Annexin-7, ...
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Disease relevance of Anxa7


High impact information on Anxa7


Biological context of Anxa7

  • Our results favor an involvement of annexin A7 in Ca(2+)-dependent signaling or Ca(2+) homeostasis in astrocytes [8].
  • A search for annexin A7 binding partners with advanced biochemical methods confirmed sorcin as the major binding protein [8].
  • Two sets of cDNAs encoding mouse synexin were isolated from a liver cDNA library and sequenced [9].
  • The amino acid sequence of mouse synexin shows a high degree of similarity to both the unique N-terminal domain and the highly conserved C-terminal domain of previously cloned human synexin [9].
  • We have isolated and characterized the gene encoding mouse synexin, which consists of 14 exons and spans approximately 30 kbp of genomic DNA [10].

Anatomical context of Anxa7

  • The lack of annexin A7 affects functions of primary astrocytes [8].
  • The results obtained indicate a developmentally and Ca(2+)-regulated localization and expression of annexin VII and raise the possibility that annexin VII may play a role in excitation-contraction coupling in skeletal muscle [1].
  • In the presence of 100 microM extracellular Ca2+, annexin VII remained bound to the plasma membrane even in the presence of high digitonin concentrations [1].
  • Immunofluorescence showed that annexin VII was located in the cytosol of mononucleated and fused polynucleated cultured cells, whereas in striated muscle, annexin VII was located preferentially at the plasma membrane and the transverse tubules [1].
  • We used PCR to isolate from a lambda gt11-mouse fibroblast library annexin VII cDNA fragments corresponding to the two isoforms found in both humans and Dictyostelium discoideum [1].

Associations of Anxa7 with chemical compounds

  • Annexin A7 is a Ca(2+)- and phospholipid-binding protein, which is thought to function in membrane organization and Ca(2+)-dependent signaling processes [8].
  • Permeabilization of L6 cells with digitonin in the presence of 5 mM EGTA led to a release of annexin VII from the cells, which paralleled the loss of cytosolic lactate dehydrogenase (LDH) at low detergent concentrations (50 microM) [1].
  • Incubation with the Ca(2+)-specific ionophore A23187 and 100 microM extracellular Ca2+ led to a redistribution of annexin VII from the cytosol to the plasma membrane after 30 minutes of incubation [1].
  • We report that although control islets respond to glucose in vitro by a transient increment in ITPR3 mRNA, the islets from the Anx7(+/-) mouse remain low [11].
  • Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7 [12].

Physical interactions of Anxa7

  • In turn, the lack of complex formation between the sorcin Ca(2+) binding domain (33-198) and synexin maps the annexin binding site to the N-terminal region of the sorcin polypeptide chain [13].

Other interactions of Anxa7


Analytical, diagnostic and therapeutic context of Anxa7


  1. Expression and localization of annexin VII (synexin) in muscle cells. Selbert, S., Fischer, P., Pongratz, D., Stewart, M., Noegel, A.A. J. Cell. Sci. (1995) [Pubmed]
  2. Influence of the Anx7 (+/-) knockout mutation and fasting stress on the genomics of the mouse adrenal gland. Srivastava, M., Kumar, P., Leighton, X., Glasman, M., Goping, G., Eidelman, O., Pollard, H.B. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  3. Distinct Effects of Annexin A7 and p53 on Arachidonate Lipoxygenation in Prostate Cancer Cells Involve 5-Lipoxygenase Transcription. Torosyan, Y., Dobi, A., Naga, S., Mezhevaya, K., Glasman, M., Norris, C., Jiang, G., Mueller, G., Pollard, H., Srivastava, M. Cancer Res. (2006) [Pubmed]
  4. Annexin VII relocalization as a result of dystrophin deficiency. Selbert, S., Fischer, P., Menke, A., Jockusch, H., Pongratz, D., Noegel, A.A. Exp. Cell Res. (1996) [Pubmed]
  5. Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Srivastava, M., Montagna, C., Leighton, X., Glasman, M., Naga, S., Eidelman, O., Ried, T., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes. Herr, C., Smyth, N., Ullrich, S., Yun, F., Sasse, P., Hescheler, J., Fleischmann, B., Lasek, K., Brixius, K., Schwinger, R.H., Fässler, R., Schröder, R., Noegel, A.A. Mol. Cell. Biol. (2001) [Pubmed]
  7. Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. Magendzo, K., Shirvan, A., Cultraro, C., Srivastava, M., Pollard, H.B., Burns, A.L. J. Biol. Chem. (1991) [Pubmed]
  8. The lack of annexin A7 affects functions of primary astrocytes. Clemen, C.S., Herr, C., Hövelmeyer, N., Noegel, A.A. Exp. Cell Res. (2003) [Pubmed]
  9. Mouse synexin (annexin VII) polymorphisms and a phylogenetic comparison with other synexins. Zhang-Keck, Z.Y., Burns, A.L., Pollard, H.B. Biochem. J. (1993) [Pubmed]
  10. Genomic organization and chromosomal localization of the mouse synexin gene. Zhang-Keck, Z.Y., Srivastava, M., Kozak, C.A., Caohuy, H., Shirvan, A., Burns, A.L., Pollard, H.B. Biochem. J. (1994) [Pubmed]
  11. Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans. Srivastava, M., Eidelman, O., Leighton, X., Glasman, M., Goping, G., Pollard, H.B. Mol. Med. (2002) [Pubmed]
  12. Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7. Naidu, D.G., Raha, A., Chen, X.L., Spitzer, A.R., Chander, A. Biochim. Biophys. Acta (2005) [Pubmed]
  13. The sorcin-annexin VII calcium-dependent interaction requires the sorcin N-terminal domain. Verzili, D., Zamparelli, C., Mattei, B., Noegel, A.A., Chiancone, E. FEBS Lett. (2000) [Pubmed]
  14. Nuclear localization of Annexin A7 during murine brain development. Rick, M., Ramos Garrido, S.I., Herr, C., Thal, D.R., Noegel, A.A., Clemen, C.S. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  15. The in vivo role of annexin VII (synexin): characterization of an annexin VII-deficient Dictyostelium mutant indicates an involvement in Ca(2+)-regulated processes. Döring, V., Veretout, F., Albrecht, R., Mühlbauer, B., Schlatterer, C., Schleicher, M., Noegel, A.A. J. Cell. Sci. (1995) [Pubmed]
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