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Gene Review

AMICA1  -  adhesion molecule, interacts with CXADR...

Homo sapiens

Synonyms: AMICA, Adhesion molecule interacting with CXADR antigen 1, CREA7-1, CREA7-4, Dendritic cell-specific protein CREA7-1, ...
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Disease relevance of AMICA1


High impact information on AMICA1


Biological context of AMICA1

  • Clinical presentation of osteoarthritis in general practice: determinants of pain in Italian patients in the AMICA study [4].
  • Experiments were designed to examine if Actinomycin D, an antibiotic, and Amica 30, a homeopathic drug used against shock and injury, can ameliorate cytogenetic damage induced by single or multiple exposures to ultrasonication [5].

Anatomical context of AMICA1

  • Taken together, these results indicate that JAML and CAR are a novel pair of adhesion molecules that play an important role in modulating PMN migration cross epithelial tight junctions [2].
  • Experiments with a JAML fusion protein revealed specific binding of JAML to epithelial CAR expressed at tight junctions in T84 cell monolayers and normal human colonic mucosa [2].

Analytical, diagnostic and therapeutic context of AMICA1


  1. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Moog-Lutz, C., Cavé-Riant, F., Guibal, F.C., Breau, M.A., Di Gioia, Y., Couraud, P.O., Cayre, Y.E., Bourdoulous, S., Lutz, P.G. Blood (2003) [Pubmed]
  2. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Zen, K., Liu, Y., McCall, I.C., Wu, T., Lee, W., Babbin, B.A., Nusrat, A., Parkos, C.A. Mol. Biol. Cell (2005) [Pubmed]
  3. Do physicians treat symptomatic osteoarthritis patients properly? Results of the AMICA experience. Sarzi-Puttini, P., Cimmino, M.A., Scarpa, R., Caporali, R., Parazzini, F., Zaninelli, A., Atzeni, F., Marcolongo, R. Semin. Arthritis Rheum. (2005) [Pubmed]
  4. Clinical presentation of osteoarthritis in general practice: determinants of pain in Italian patients in the AMICA study. Cimmino, M.A., Sarzi-Puttini, P., Scarpa, R., Caporali, R., Parazzini, F., Zaninelli, A., Marcolongo, R. Semin. Arthritis Rheum. (2005) [Pubmed]
  5. Cytogenetical effects of sonication in mice and their modulations by actinomycin D and a homeopathic drug, Arnica 30. Chakrabarti, J., Biswas, S.J., Khuda-Bukhsh, A.R. Indian J. Exp. Biol. (2001) [Pubmed]
  6. Comorbid conditions in the AMICA study patients: effects on the quality of life and drug prescriptions by general practitioners and specialists. Caporali, R., Cimmino, M.A., Sarzi-Puttini, P., Scarpa, R., Parazzini, F., Zaninelli, A., Ciocci, A., Montecucco, C. Semin. Arthritis Rheum. (2005) [Pubmed]
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