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Gene Review

F11R  -  F11 receptor

Homo sapiens

Synonyms: CD321, JAM, JAM-1, JAM-A, JAM1, ...
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Disease relevance of F11R


Psychiatry related information on F11R


High impact information on F11R


Chemical compound and disease context of F11R


Biological context of F11R

  • Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs) [1].
  • The F11R is a 32-/35-kd protein duplex that serves as the binding site through which a stimulatory monoclonal antibody causes platelet aggregation and granule secretion [1].
  • A physiological role for the F11R protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen [1].
  • Modeling of the 3D structure of the extracellular domain of the human platelet F11R suggests that these two regions form an active site within the conformation of this CAM [21].
  • This is evidenced by the inhibition of platelet adhesion to endothelial cells by recombinant soluble form of the F11R, and by two F11R peptides with amino acid sequences of the N-terminal region, and in the 1(st) Ig fold of the F11R, respectively [2].

Anatomical context of F11R

  • The role of F11R/JAM in the interaction of platelets with endothelial cells was investigated in the current studies [2].
  • Furthermore, platelets adhere to cytokine- (TNF-alpha, INF-gamma) stimulated human umbilical vein endothelial cells (HUVEC), and approximately 40-60% of the adhesive force is exerted by homophilic interactions between the F11R of platelets and EC [2].
  • This study suggests a role for F11R in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes [2].
  • We demonstrate that platelet secretion and aggregation through the F11R involves actin filament assembly that is dependent on phosphoinositide-3 kinase activation, and inhibitable by wortmannin [22].
  • On the other hand, F11R-mediated events resulting from the binding of platelets to an immobilized surface of M.Ab.F11 lead to platelet adhesion and spreading through the development of filopodia and lammelipodia [22].

Associations of F11R with chemical compounds


Physical interactions of F11R


Co-localisations of F11R


Regulatory relationships of F11R


Other interactions of F11R


Analytical, diagnostic and therapeutic context of F11R


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