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Gene Review

Bmp8b  -  bone morphogenetic protein 8b

Mus musculus

Synonyms: BMP-8B, Bone morphogenetic protein 8B, Op3
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Disease relevance of Bmp8b


High impact information on Bmp8b


Biological context of Bmp8b


Anatomical context of Bmp8b

  • In addition, both Bmp8a and Bmp8b are expressed in the testis during specific stages of spermatogenesis, with the highest levels of RNA in stage 6-8 round spermatids after 3 weeks of age [4].
  • By contrast, high levels of Bmp8b RNA are found in the decidual cells of the uterus, and both genes are expressed in the trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin [4].
  • Requirement of Bmp8b for the generation of primordial germ cells in the mouse [5].
  • In this study, we report that Bmp8b, a member of the Gbb-60A class of the BMP superfamily, is expressed in the extraembryonic ectoderm in pregastrula and gastrula stage mouse embryos and is required for PGC generation [5].
  • In addition, Bmp8b homozygous null embryos on both genetic backgrounds have a short allantois, and this organ is missing in some more severe mutants [5].

Other interactions of Bmp8b

  • Previous studies have demonstrated that extraembryonic ectoderm-derived BMP4 and BMP8B are both required for PGC generation [7].
  • We have previously shown that Bmp7, Bmp8a, and Bmp8b of the 60A class of Bmp genes have additive effects in spermatogenesis and in maintaining the epididymal integrity of the caput and caudal regions [8].


  1. Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Zhao, G.Q., Liaw, L., Hogan, B.L. Development (1998) [Pubmed]
  2. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Zhao, G.Q., Deng, K., Labosky, P.A., Liaw, L., Hogan, B.L. Genes Dev. (1996) [Pubmed]
  3. Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways. Ying, Y., Qi, X., Zhao, G.Q. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. Zhao, G.Q., Hogan, B.L. Mech. Dev. (1996) [Pubmed]
  5. Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Ying, Y., Liu, X.M., Marble, A., Lawson, K.A., Zhao, G.Q. Mol. Endocrinol. (2000) [Pubmed]
  6. Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. Zhao, G.Q., Hogan, B.L. Mech. Dev. (1997) [Pubmed]
  7. Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Ying, Y., Zhao, G.Q. Dev. Biol. (2001) [Pubmed]
  8. Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity. Hu, J., Chen, Y.X., Wang, D., Qi, X., Li, T.G., Hao, J., Mishina, Y., Garbers, D.L., Zhao, G.Q. Dev. Biol. (2004) [Pubmed]
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