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Gene Review

Casq2  -  calsequestrin 2

Mus musculus

Synonyms: AA033488, AW146219, Calsequestrin, cardiac muscle isoform, Calsequestrin-2, ESTM52, ...
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Disease relevance of Casq2


High impact information on Casq2


Biological context of Casq2

  • The cardiac calsequestrin gene consists of 11 exons and its 5' flanking region is characterized by the presence of a TATA-like box, muscle specific promoter elements such as 7 E-boxes, 1 MEF-2, 1 MCBF and 1 Repeat (musS) motifs, as well as several muscle non-specific transcriptional elements (AP-2A, NRE1, NRE2, p53, Spel and TFI-IIA) [3].

Anatomical context of Casq2


  1. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. Sato, Y., Ferguson, D.G., Sako, H., Dorn, G.W., Kadambi, V.J., Yatani, A., Hoit, B.D., Walsh, R.A., Kranias, E.G. J. Biol. Chem. (1998) [Pubmed]
  2. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. Sato, Y., Kiriazis, H., Yatani, A., Schmidt, A.G., Hahn, H., Ferguson, D.G., Sako, H., Mitarai, S., Honda, R., Mesnard-Rouiller, L., Frank, K.F., Beyermann, B., Wu, G., Fujimori, K., Dorn, G.W., Kranias, E.G. J. Biol. Chem. (2001) [Pubmed]
  3. Structure and expression of the mouse cardiac calsequestrin gene. Frank, K.F., Mesnard-Rouiller, L., Chu, G., Young, K.B., Zhao, W., Haghighi, K., Sato, Y., Kranias, E.G. Basic Res. Cardiol. (2001) [Pubmed]
  4. Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy. Tavi, P., Hansson, A., Zhang, S.J., Larsson, N.G., Westerblad, H. Hum. Mol. Genet. (2005) [Pubmed]
  5. Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin. Jones, L.R., Suzuki, Y.J., Wang, W., Kobayashi, Y.M., Ramesh, V., Franzini-Armstrong, C., Cleemann, L., Morad, M. J. Clin. Invest. (1998) [Pubmed]
  6. Regulation of GATA-4 and AP-1 in transgenic mice overexpressing cardiac calsequestrin. Suzuki, Y.J., Ikeda, T., Shi, S.S., Kitta, K., Kobayashi, Y.M., Morad, M., Jones, L.R., Blumberg, J.B. Cell Calcium (1999) [Pubmed]
  7. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. Knollmann, B.C., Knollmann-Ritschel, B.E., Weissman, N.J., Jones, L.R., Morad, M. J. Physiol. (Lond.) (2000) [Pubmed]
  8. Cloning of the genes encoding mouse cardiac and skeletal calsequestrins: expression pattern during embryogenesis. Park, K.W., Goo, J.H., Chung, H.S., Kim, H., Kim, D.H., Park, W.J. Gene (1998) [Pubmed]
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