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CD36  -  CD36 molecule (thrombospondin receptor)

Bos taurus

Synonyms: GPIIIB, GPIV, PAS-4
 
 
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Disease relevance of CD36

 

High impact information on CD36

 

Biological context of CD36

 

Anatomical context of CD36

 

Associations of CD36 with chemical compounds

  • In solution, both intact TSP1 and the alpha3beta1 integrin-binding peptide from TSP1 inhibit proliferation of sparse endothelial cell cultures independent of their CD36 expression [8].
  • Octanoate stimulated the accumulation of TAG in a concentration-dependent manner from 1 to 10 mM and increased lipid droplet formation and mRNA expression of CD36 (a fatty acid translocase) [9].
  • Both saturated (palmitic and stearic) and unsaturated (oleic and linoleic) fatty acids stimulated the accumulation of TAG in a concentration-dependent manner from 50 to 400 microM and the expression of mRNA expression for CD36, which is involved in the uptake and secretion of long-chain fatty acids [10].
  • Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells [9].
  • The properties and amino acid sequences of the following proteins are discussed in detail: MUC1, xanthine dehydrogenase/oxidase, CD36, butyrophilin, adipophilin, periodic acid Schiff 6/7 (PAS 6/7), and fatty acid binding protein [11].
 

Co-localisations of CD36

 

Other interactions of CD36

  • Advanced glycation end products (AGE) are known to serve as ligands for the scavenger receptors such as SR-A, CD36 and SR-BI [13].
 

Analytical, diagnostic and therapeutic context of CD36

  • N-Terminal sequence analyses of human and bovine PAS IV revealed homology to the N-terminal sequence of the 88-kDa human endothelial and platelet glycoprotein CD36 [3].
  • Finally, to evaluate the in vivo relevance of the induction of CD36 mRNA expression by lipoproteins, peritoneal macrophages were isolated from mice following intraperitoneal injection of lipoproteins [14].
  • Induction of CD36 mRNA expression was paralleled by an increase in CD36 protein as determined by Western blot with the greatest induction by OxLDL (4-fold) [14].
  • The location of PAS IV was determined in bovine tissues by using immunofluorescence techniques [2].
  • Two monoclonal antibodies, E-1 and E-3, were shown by solid-phase immunoassay and immunoaffinity chromatography to be specific for PAS IV (of Mr 76000) in milk-fat-globule membrane and recognize a glycoprotein of slightly higher Mr (85000) in heart [15].

References

  1. Pathological roles of advanced glycation end product receptors SR-A and CD36. Horiuchi, S., Unno, Y., Usui, H., Shikata, K., Takaki, K., Koito, W., Sakamoto, Y., Nagai, R., Makino, K., Sasao, A., Wada, J., Makino, H. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  2. Characterization of an apically derived epithelial membrane glycoprotein from bovine milk, which is expressed in capillary endothelia in diverse tissues. Greenwalt, D.E., Mather, I.H. J. Cell Biol. (1985) [Pubmed]
  3. PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV). Greenwalt, D.E., Watt, K.W., So, O.Y., Jiwani, N. Biochemistry (1990) [Pubmed]
  4. Assignment of disulfide bridges in bovine CD36. Rasmussen, J.T., Berglund, L., Rasmussen, M.S., Petersen, T.E. Eur. J. Biochem. (1998) [Pubmed]
  5. Structural characterization of bovine CD36 from the milk fat globule membrane. Berglund, L., Petersen, T.E., Rasmussen, J.T. Biochim. Biophys. Acta (1996) [Pubmed]
  6. Association and coexpression of fatty-acid-binding protein and glycoprotein CD36 in the bovine mammary gland. Spitsberg, V.L., Matitashvili, E., Gorewit, R.C. Eur. J. Biochem. (1995) [Pubmed]
  7. Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36. Greenwalt, D.E., Watt, K.W., Hasler, T., Howard, R.J., Patel, S. J. Biol. Chem. (1990) [Pubmed]
  8. Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1. Chandrasekaran, L., He, C.Z., Al-Barazi, H., Krutzsch, H.C., Iruela-Arispe, M.L., Roberts, D.D. Mol. Biol. Cell (2000) [Pubmed]
  9. Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells. Yonezawa, T., Yonekura, S., Sanosaka, M., Hagino, A., Katoh, K., Obara, Y. J. Dairy Res. (2004) [Pubmed]
  10. Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells. Yonezawa, T., Yonekura, S., Kobayashi, Y., Hagino, A., Katoh, K., Obara, Y. J. Dairy Sci. (2004) [Pubmed]
  11. A review and proposed nomenclature for major proteins of the milk-fat globule membrane. Mather, I.H. J. Dairy Sci. (2000) [Pubmed]
  12. Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development. Greenaway, J., Gentry, P.A., Feige, J.J., LaMarre, J., Petrik, J.J. Biol. Reprod. (2005) [Pubmed]
  13. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE). Jono, T., Miyazaki, A., Nagai, R., Sawamura, T., Kitamura, T., Horiuchi, S. FEBS Lett. (2002) [Pubmed]
  14. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. Han, J., Hajjar, D.P., Febbraio, M., Nicholson, A.C. J. Biol. Chem. (1997) [Pubmed]
  15. Specific antibodies to PAS IV, a glycoprotein of bovine milk-fat-globule membrane, bind to a similar protein in cardiac endothelial cells and epithelial cells of lung bronchioles. Greenwalt, D.E., Johnson, V.G., Mather, I.H. Biochem. J. (1985) [Pubmed]
 
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