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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heteroduplex Analysis

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Disease relevance of Heteroduplex Analysis


High impact information on Heteroduplex Analysis


Chemical compound and disease context of Heteroduplex Analysis


Biological context of Heteroduplex Analysis


Anatomical context of Heteroduplex Analysis


Associations of Heteroduplex Analysis with chemical compounds


Gene context of Heteroduplex Analysis

  • Although the clonal composition of CD8+ T cells as determined by heteroduplex analysis was similar in both compartments, there was greater CD28 expression in the tonsil population, indicating that they were less differentiated [27].
  • The mutation detection strategy included polymerase chain reaction amplification of each exon of ITGB4, followed by heteroduplex analysis and direct nucleotide sequencing [28].
  • The amplified sequences were used to study sequence variations of the LAMB3 gene in patients with JEB and unrelated individuals using heteroduplex analysis [29].
  • We have transferred heteroduplex analysis (HA) by conformation-sensitive gel electrophoresis of the two major breast cancer (BC) predisposing genes, BRCA1 and BRCA2, to a multicapillary DNA sequencer in order to increase the throughput of this technique [30].
  • Mutation analysis using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis and direct nucleotide sequencing demonstrated pathogenetic COL7A1 mutations in each case [31].

Analytical, diagnostic and therapeutic context of Heteroduplex Analysis


  1. Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis. UKCCCR Familial Ovarian Cancer Study Group. Gayther, S.A., Harrington, P., Russell, P., Kharkevich, G., Garkavtseva, R.F., Ponder, B.A. Am. J. Hum. Genet. (1996) [Pubmed]
  2. Fifteen novel FBN1 mutations causing Marfan syndrome detected by heteroduplex analysis of genomic amplicons. Nijbroek, G., Sood, S., McIntosh, I., Francomano, C.A., Bull, E., Pereira, L., Ramirez, F., Pyeritz, R.E., Dietz, H.C. Am. J. Hum. Genet. (1995) [Pubmed]
  3. Hereditary coproporphyria: exon screening by heteroduplex analysis detects three novel mutations in the coproporphyrinogen oxidase gene. Schreiber, W.E., Zhang, X., Senz, J., Jamani, A. Hum. Mutat. (1997) [Pubmed]
  4. Four frameshift mutations in neurofibromatosis type 1 caused by small insertions. Colman, S.D., Abernathy, C.R., Ho, V.T., Wallace, M.R. J. Med. Genet. (1997) [Pubmed]
  5. Differential selection of specific human immunodeficiency virus type 1/JC499 variants after mucosal and parenteral inoculation of chimpanzees. Wei, Q., Fultz, P.N. J. Virol. (2002) [Pubmed]
  6. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. Huntsman, D.G., Carneiro, F., Lewis, F.R., MacLeod, P.M., Hayashi, A., Monaghan, K.G., Maung, R., Seruca, R., Jackson, C.E., Caldas, C. N. Engl. J. Med. (2001) [Pubmed]
  7. Nine introns with conserved boundary sequences in the Euglena gracilis chloroplast ribulose-1,5-bisphosphate carboxylase gene. Koller, B., Gingrich, J.C., Stiegler, G.L., Farley, M.A., Delius, H., Hallick, R.B. Cell (1984) [Pubmed]
  8. The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence. McClelland, A., Kühn, L.C., Ruddle, F.H. Cell (1984) [Pubmed]
  9. Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Moran, L., Mirault, M.E., Tissières, A., Lis, J., Schedl, P., Artavanis-Tsakonas, S., Gehring, W.J. Cell (1979) [Pubmed]
  10. Comparison of prophylactic oophorectomy specimens from carriers and noncarriers of a BRCA1 or BRCA2 gene mutation. United Kingdom Coordinating Committee on Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group. Stratton, J.F., Buckley, C.H., Lowe, D., Ponder, B.A. J. Natl. Cancer Inst. (1999) [Pubmed]
  11. Temperature-mediated heteroduplex analysis for detection of pncA mutations associated with pyrazinamide resistance and differentiation between Mycobacterium tuberculosis and Mycobacterium bovis by denaturing high- performance liquid chromatography. Mohamed, A.M., Bastola, D.R., Morlock, G.P., Cooksey, R.C., Hinrichs, S.H. J. Clin. Microbiol. (2004) [Pubmed]
  12. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Lee, C.N., Su, Y.N., Cheng, W.F., Lin, M.T., Wang, J.K., Wu, M.H., Hsieh, F.J. Acta obstetricia et gynecologica Scandinavica. (2005) [Pubmed]
  13. Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide. Chang, A.C., Cochet, M., Cohen, S.N. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  14. Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29). Dalla-Favera, R., Gelmann, E.P., Martinotti, S., Franchini, G., Papas, T.S., Gallo, R.C., Wong-Staal, F. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  15. A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in lethal (Herlitz) junctional epidermolysis bullosa. Kivirikko, S., McGrath, J.A., Baudoin, C., Aberdam, D., Ciatti, S., Dunnill, M.G., McMillan, J.R., Eady, R.A., Ortonne, J.P., Meneguzzi, G. Hum. Mol. Genet. (1995) [Pubmed]
  16. Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17. Carey, A.H., Waterworth, D., Patel, K., White, D., Little, J., Novelli, P., Franks, S., Williamson, R. Hum. Mol. Genet. (1994) [Pubmed]
  17. Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. Chen, Z., Telfier, P., Gettie, A., Reed, P., Zhang, L., Ho, D.D., Marx, P.A. J. Virol. (1996) [Pubmed]
  18. Heteroduplex analysis of T-cell receptor gamma gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas. Bottaro, M., Berti, E., Biondi, A., Migone, N., Crosti, L. Blood (1994) [Pubmed]
  19. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations. Langerak, A.W., Szczepański, T., van der Burg, M., Wolvers-Tettero, I.L., van Dongen, J.J. Leukemia (1997) [Pubmed]
  20. An alternative approach to the assessment of gamma delta T-cell clonality in celiac disease intestinal lesions through cDNA heteroduplex analysis of T-cell receptor VJ junctions. Giachino, C., Rocci, M.P., De Libero, G., Oderda, G., Ansaldi, N., Migone, N. Hum. Immunol. (1994) [Pubmed]
  21. Diagnosis of conjunctival B-cell lymphoma by polymerase chain reaction heteroduplex analysis. Strauss, E.C., Warren, J.F., Margolis, T.P., Holsclaw, D.S. Am. J. Ophthalmol. (2003) [Pubmed]
  22. Differential subcellular mRNA targeting: deletion of a single nucleotide prevents the transport to axons but not to dendrites of rat hypothalamic magnocellular neurons. Mohr, E., Morris, J.F., Richter, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  23. Oligoclonality of lung T lymphocytes following exposure to allergen in asthma. Burastero, S.E., Crimi, E., Balbo, A., Vavassori, M., Borgonovo, B., Gaffi, D., Frittoli, E., Casorati, G., Rossi, G.A. J. Immunol. (1995) [Pubmed]
  24. Heterology of mitochondrial DNA from mammals detected by electron microscopic heteroduplex analyses. Christiansen, G., Christiansen, C. Nucleic Acids Res. (1983) [Pubmed]
  25. Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR. van der Velden, V.H., Willemse, M.J., van der Schoot, C.E., Hählen, K., van Wering, E.R., van Dongen, J.J. Leukemia (2002) [Pubmed]
  26. A novel locus for Leber congenital amaurosis (LCA4) with anterior keratoconus mapping to chromosome 17p13. Hameed, A., Khaliq, S., Ismail, M., Anwar, K., Ebenezer, N.D., Jordan, T., Mehdi, S.Q., Payne, A.M., Bhattacharya, S.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  27. Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection. Soares, M.V., Plunkett, F.J., Verbeke, C.S., Cook, J.E., Faint, J.M., Belaramani, L.L., Fletcher, J.M., Hammerschmitt, N., Rustin, M., Bergler, W., Beverley, P.C., Salmon, M., Akbar, A.N. Blood (2004) [Pubmed]
  28. Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4). Pulkkinen, L., Kim, D.U., Uitto, J. Am. J. Pathol. (1998) [Pubmed]
  29. Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3). Pulkkinen, L., McGrath, J.A., Christiano, A.M., Uitto, J. Hum. Mutat. (1995) [Pubmed]
  30. Rapid mutation detection in complex genes by heteroduplex analysis with capillary array electrophoresis. Velasco, E., Infante, M., Durán, M., Esteban-Cardeñosa, E., Lastra, E., García-Girón, C., Miner, C. Electrophoresis (2005) [Pubmed]
  31. Allelic heterogeneity of dominant and recessive COL7A1 mutations underlying epidermolysis bullosa pruriginosa. Mellerio, J.E., Ashton, G.H., Mohammedi, R., Lyon, C.C., Kirby, B., Harman, K.E., Salas-Alanis, J.C., Atherton, D.J., Harrison, P.V., Griffiths, W.A., Black, M.M., Eady, R.A., McGrath, J.A. J. Invest. Dermatol. (1999) [Pubmed]
  32. Neurofibromatosis type 1 (NF1): the search for mutations by PCR-heteroduplex analysis on Hydrolink gels. Shen, M.H., Harper, P.S., Upadhyaya, M. Hum. Mol. Genet. (1993) [Pubmed]
  33. Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences. Lin, P.F., Lieberman, H.B., Yeh, D.B., Xu, T., Zhao, S.Y., Ruddle, F.H. Mol. Cell. Biol. (1985) [Pubmed]
  34. Seven novel additional small mutations and a new alternative splicing in the human dystrophin gene detected by heteroduplex analysis and restricted RT-PCR heteroduplex analysis of illegitimate transcripts. Barbieri, A.M., Soriani, N., Ferlini, A., Michelato, A., Ferrari, M., Carrera, P. Eur. J. Hum. Genet. (1996) [Pubmed]
  35. Applied molecular genetic techniques for prenatal diagnosis. Van den Veyver, I.B., Roa, B.B. Current opinion in obstetrics & gynecology. (1998) [Pubmed]
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