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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Heteroduplex Analysis

 
 
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Disease relevance of Heteroduplex Analysis

 

High impact information on Heteroduplex Analysis

 

Chemical compound and disease context of Heteroduplex Analysis

 

Biological context of Heteroduplex Analysis

 

Anatomical context of Heteroduplex Analysis

 

Associations of Heteroduplex Analysis with chemical compounds

 

Gene context of Heteroduplex Analysis

  • Although the clonal composition of CD8+ T cells as determined by heteroduplex analysis was similar in both compartments, there was greater CD28 expression in the tonsil population, indicating that they were less differentiated [27].
  • The mutation detection strategy included polymerase chain reaction amplification of each exon of ITGB4, followed by heteroduplex analysis and direct nucleotide sequencing [28].
  • The amplified sequences were used to study sequence variations of the LAMB3 gene in patients with JEB and unrelated individuals using heteroduplex analysis [29].
  • We have transferred heteroduplex analysis (HA) by conformation-sensitive gel electrophoresis of the two major breast cancer (BC) predisposing genes, BRCA1 and BRCA2, to a multicapillary DNA sequencer in order to increase the throughput of this technique [30].
  • Mutation analysis using polymerase chain reaction amplification of genomic DNA, heteroduplex analysis and direct nucleotide sequencing demonstrated pathogenetic COL7A1 mutations in each case [31].
 

Analytical, diagnostic and therapeutic context of Heteroduplex Analysis

References

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  18. Heteroduplex analysis of T-cell receptor gamma gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas. Bottaro, M., Berti, E., Biondi, A., Migone, N., Crosti, L. Blood (1994) [Pubmed]
  19. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations. Langerak, A.W., Szczepański, T., van der Burg, M., Wolvers-Tettero, I.L., van Dongen, J.J. Leukemia (1997) [Pubmed]
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  21. Diagnosis of conjunctival B-cell lymphoma by polymerase chain reaction heteroduplex analysis. Strauss, E.C., Warren, J.F., Margolis, T.P., Holsclaw, D.S. Am. J. Ophthalmol. (2003) [Pubmed]
  22. Differential subcellular mRNA targeting: deletion of a single nucleotide prevents the transport to axons but not to dendrites of rat hypothalamic magnocellular neurons. Mohr, E., Morris, J.F., Richter, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
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  25. Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR. van der Velden, V.H., Willemse, M.J., van der Schoot, C.E., Hählen, K., van Wering, E.R., van Dongen, J.J. Leukemia (2002) [Pubmed]
  26. A novel locus for Leber congenital amaurosis (LCA4) with anterior keratoconus mapping to chromosome 17p13. Hameed, A., Khaliq, S., Ismail, M., Anwar, K., Ebenezer, N.D., Jordan, T., Mehdi, S.Q., Payne, A.M., Bhattacharya, S.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  27. Integration of apoptosis and telomere erosion in virus-specific CD8+ T cells from blood and tonsils during primary infection. Soares, M.V., Plunkett, F.J., Verbeke, C.S., Cook, J.E., Faint, J.M., Belaramani, L.L., Fletcher, J.M., Hammerschmitt, N., Rustin, M., Bergler, W., Beverley, P.C., Salmon, M., Akbar, A.N. Blood (2004) [Pubmed]
  28. Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4). Pulkkinen, L., Kim, D.U., Uitto, J. Am. J. Pathol. (1998) [Pubmed]
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  30. Rapid mutation detection in complex genes by heteroduplex analysis with capillary array electrophoresis. Velasco, E., Infante, M., Durán, M., Esteban-Cardeñosa, E., Lastra, E., García-Girón, C., Miner, C. Electrophoresis (2005) [Pubmed]
  31. Allelic heterogeneity of dominant and recessive COL7A1 mutations underlying epidermolysis bullosa pruriginosa. Mellerio, J.E., Ashton, G.H., Mohammedi, R., Lyon, C.C., Kirby, B., Harman, K.E., Salas-Alanis, J.C., Atherton, D.J., Harrison, P.V., Griffiths, W.A., Black, M.M., Eady, R.A., McGrath, J.A. J. Invest. Dermatol. (1999) [Pubmed]
  32. Neurofibromatosis type 1 (NF1): the search for mutations by PCR-heteroduplex analysis on Hydrolink gels. Shen, M.H., Harper, P.S., Upadhyaya, M. Hum. Mol. Genet. (1993) [Pubmed]
  33. Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences. Lin, P.F., Lieberman, H.B., Yeh, D.B., Xu, T., Zhao, S.Y., Ruddle, F.H. Mol. Cell. Biol. (1985) [Pubmed]
  34. Seven novel additional small mutations and a new alternative splicing in the human dystrophin gene detected by heteroduplex analysis and restricted RT-PCR heteroduplex analysis of illegitimate transcripts. Barbieri, A.M., Soriani, N., Ferlini, A., Michelato, A., Ferrari, M., Carrera, P. Eur. J. Hum. Genet. (1996) [Pubmed]
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