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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

New England

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Disease relevance of New England


Psychiatry related information on New England


High impact information on New England

  • METHODS: We compared the results of large randomized, controlled trials (involving 1000 patients or more) that were published in four journals (the New England Journal of Medicine, the Lancet, the Annals of Internal Medicine, and the Journal of the American Medical Association) with the results of meta-analyses published earlier on the same topics [10].
  • The highest rate of use was in the Middle Atlantic states (20.0 percent) and New England (17.2 percent), and the lowest was in the East South Central states (5.9 percent) and the West South Central states (7.3 percent) [11].
  • Serum samples from all cadaver organ donors to the New England Organ Bank between 1986 and 1990 were screened retrospectively for antibodies to HCV (anti-HCV) by enzyme-linked immunosorbent assay (ELISA) [12].
  • METHODS: Five frequently cited journals were investigated: Annals of Internal Medicine, BMJ, JAMA, The Lancet, and the New England Journal of Medicine. For each journal, 4 years were evaluated: 1989, 1992, 1995, and 1998 [13].
  • DESIGN AND SETTING: Analysis of 270 reports of RCTs published in 1998 in the Annals of Internal Medicine (AIM; n = 19), BMJ (n = 42), JAMA (n = 45), The Lancet (n = 81), and The New England Journal of Medicine (NEJM; n = 83) [14].

Chemical compound and disease context of New England


Biological context of New England


Anatomical context of New England


Associations of New England with chemical compounds

  • SETTING--A large health insurer in New England. PATIENTS--Health plan members with 1 or more paid pharmacy claims for products containing terfenadine between January 1990 and June 1994 [28].
  • The comparison of the ER-EIA with the New England Nuclear steroid binding assay produced a slope of 1.13 [25].
  • However, the norepinephrine content of several peripheral tissues of these rats did not differ from those of the New England Deaconess Hospital control rats, and their dopamine content, although slightly higher, was much lower than would have been expected from the plasma dopamine levels [29].
  • We used automated health insurance claims records of a New England insurer to assess the relation between salmeterol and severe nonfatal asthma [30].
  • Using outpatient pharmacy claims from a New England health insurer, we calculated a concomitant dispensing rate for each calendar month as the number of concomitant cisapride dispensings divided by the total number of cisapride dispensings [31].

Gene context of New England

  • An Alu1- polymorphism in the HEXA gene is common in Ashkenazi and Sephardic Jews, Israeli Arabs, and French Canadians of Quebec and northern New England [32].
  • CONCLUSIONS: MRSA accounts for an increasing proportion of all pediatric S aureus infections in southern New England. A significant percentage of these cases are due to CA-MRSA [33].
  • This study surveyed general education teachers in northern New England to determine the classroom strategies teachers commonly use and perceive as being effective for improving the performance of children with ADHD [34].
  • HLA-B, DR matching and cadaver renal allograft survival in New England. New England Organ Bank [35].
  • PARTICIPANTS--All first authors of scientific articles published in JAMA and The New England Journal of Medicine during a 6-month period [36].

Analytical, diagnostic and therapeutic context of New England


  1. Atovaquone and azithromycin for the treatment of babesiosis. Krause, P.J., Lepore, T., Sikand, V.K., Gadbaw, J., Burke, G., Telford, S.R., Brassard, P., Pearl, D., Azlanzadeh, J., Christianson, D., McGrath, D., Spielman, A. N. Engl. J. Med. (2000) [Pubmed]
  2. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. Laden, F., Collman, G., Iwamoto, K., Alberg, A.J., Berkowitz, G.S., Freudenheim, J.L., Hankinson, S.E., Helzlsouer, K.J., Holford, T.R., Huang, H.Y., Moysich, K.B., Tessari, J.D., Wolff, M.S., Zheng, T., Hunter, D.J. J. Natl. Cancer Inst. (2001) [Pubmed]
  3. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Brash, D.E., Rudolph, J.A., Simon, J.A., Lin, A., McKenna, G.J., Baden, H.P., Halperin, A.J., Pontén, J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Linkage of scapuloperoneal spinal muscular atrophy to chromosome 12q24.1-q24.31. Isozumi, K., DeLong, R., Kaplan, J., Deng, H.X., Iqbal, Z., Hung, W.Y., Wilhelmsen, K.C., Hentati, A., Pericak-Vance, M.A., Siddique, T. Hum. Mol. Genet. (1996) [Pubmed]
  5. Risk of developing multiple sclerosis after uncomplicated optic neuritis: a long-term prospective study. Rizzo, J.F., Lessell, S. Neurology (1988) [Pubmed]
  6. Anthropogenic modification of New England salt marsh landscapes. Bertness, M.D., Ewanchuk, P.J., Silliman, B.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Women participants in research: assessing progress. Low, K.G., Joliceour, M.R., Colman, R.A., Stone, L.E., Fleisher, C.L. Women & health. (1994) [Pubmed]
  8. Medical paternalism or legal imperialism: not the only alternatives for handling Saikewicz-type cases. Buchanan, A. American journal of law & medicine. (1979) [Pubmed]
  9. Religion and spirituality in three major general medical journals from 1998 to 2000. Weaver, A.J., Flannelly, K.J., Case, D.B., Costa, K.G. South. Med. J. (2004) [Pubmed]
  10. Discrepancies between meta-analyses and subsequent large randomized, controlled trials. LeLorier, J., Grégoire, G., Benhaddad, A., Lapierre, J., Derderian, F. N. Engl. J. Med. (1997) [Pubmed]
  11. Geographic variation in the use of breast-conserving treatment for breast cancer. Nattinger, A.B., Gottlieb, M.S., Veum, J., Yahnke, D., Goodwin, J.S. N. Engl. J. Med. (1992) [Pubmed]
  12. Transmission of hepatitis C virus by organ transplantation. Pereira, B.J., Milford, E.L., Kirkman, R.L., Levey, A.S. N. Engl. J. Med. (1991) [Pubmed]
  13. Reporting number needed to treat and absolute risk reduction in randomized controlled trials. Nuovo, J., Melnikow, J., Chang, D. JAMA (2002) [Pubmed]
  14. Value of flow diagrams in reports of randomized controlled trials. Egger, M., Jüni, P., Bartlett, C. JAMA (2001) [Pubmed]
  15. Endemic giardiasis in New Hampshire: a case-control study of environmental risks. Dennis, D.T., Smith, R.P., Welch, J.J., Chute, C.G., Anderson, B., Herndon, J.L., von Reyn, C.F. J. Infect. Dis. (1993) [Pubmed]
  16. Career opportunities for infectious diseases subspecialists. Preheim, L.C. Clin. Infect. Dis. (1998) [Pubmed]
  17. Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. Prokocimer, P.G., Maze, M., Hoffman, B.B. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  18. Intravesical dimethyl sulfoxide (DMSO) for interstitial cystitis--a practical approach. Parkin, J., Shea, C., Sant, G.R. Urology (1997) [Pubmed]
  19. Genetic mechanisms contributing to reduced tetracycline susceptibility of Campylobacter isolated from organic and conventional dairy farms in the midwestern and northeastern United States. Halbert, L.W., Kaneene, J.B., Linz, J., Mansfield, L.S., Wilson, D., Ruegg, P.L., Warnick, L.D., Wells, S.J., Fossler, C.P., Campbell, A.M., Geiger-Zwald, A.M. J. Food Prot. (2006) [Pubmed]
  20. Who are the peer reviewers and how much do they review? Yankauer, A. JAMA (1990) [Pubmed]
  21. A cytogenetic study of familial medullary carcinoma of the thyroid. Wurster-Hill, D.H., Noll, W.W., Bircher, L.Y., Devlin, J., Schultz, E. Cancer Res. (1986) [Pubmed]
  22. Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children. Litonjua, A.A., Belanger, K., Celedón, J.C., Milton, D.K., Bracken, M.B., Kraft, P., Triche, E.W., Sredl, D.L., Weiss, S.T., Leaderer, B.P., Gold, D.R. J. Allergy Clin. Immunol. (2005) [Pubmed]
  23. Tumor necrosis factor genetic polymorphisms correlate with infections after liver transplantation. NEMC TNF Study Group. New England Medical Center Tumor Necrosis Factor. Freeman, R.B., Tran, C.L., Mattoli, J., Patel, K., Supran, S., Basile, F.G., Krishnamurthy, S., Aihara, R. Transplantation (1999) [Pubmed]
  24. Undetectable maternal serum unconjugated estriol levels in the second trimester: risk of perinatal complications associated with placental sulfatase deficiency. Bradley, L.A., Canick, J.A., Palomaki, G.E., Haddow, J.E. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  25. Determination of estrogen receptor in breast cancer using monoclonal antibody technology: results of a multicenter study in the United States. Jordan, V.C., Jacobson, H.I., Keenan, E.J. Cancer Res. (1986) [Pubmed]
  26. Candesartan inhibits carotid intimal thickening and ameliorates insulin resistance in balloon-injured diabetic rats. Igarashi, M., Hirata, A., Yamaguchi, H., Tsuchiya, H., Ohnuma, H., Tominaga, M., Daimon, M., Kato, T. Hypertension (2001) [Pubmed]
  27. Validation and refinement of mortality risk models for heart valve surgery. Jin, R., Grunkemeier, G.L., Starr, A. Ann. Thorac. Surg. (2005) [Pubmed]
  28. Use of terfenadine and contraindicated drugs. Thompson, D., Oster, G. JAMA (1996) [Pubmed]
  29. Metabolism and storage of catecholamines in rats with pheochromocytoma implants. Buu, N.T., Kuchel, O., Manger, W., Hulse, M.C., Chute, R.N. Hypertension (1986) [Pubmed]
  30. Risk of emergency care, hospitalization, and ICU stays for acute asthma among recipients of salmeterol. Lanes, S.F., Lanza, L.L., Wentworth, C.E. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  31. The impact of wording in "Dear doctor" letters and in black box labels. Weatherby, L.B., Nordstrom, B.L., Fife, D., Walker, A.M. Clin. Pharmacol. Ther. (2002) [Pubmed]
  32. An Alu1- polymorphism in the HEXA gene is common in Ashkenazi and Sephardic Jews, Israeli Arabs, and French Canadians of Quebec and northern New England. Grinshpun, J., Khosravi, R., Peleg, L., Goldman, B., Kaplan, F., Triggs-Raine, B., Navon, R. Hum. Mutat. (1995) [Pubmed]
  33. Community-acquired methicillin-resistant Staphylococcus aureus in southern New England children. Dietrich, D.W., Auld, D.B., Mermel, L.A. Pediatrics (2004) [Pubmed]
  34. Classroom strategies used by teachers of students with attention deficit hyperactivity disorder. Mulligan, S. Physical & occupational therapy in pediatrics. (2001) [Pubmed]
  35. HLA-B, DR matching and cadaver renal allograft survival in New England. New England Organ Bank. Carpenter, C.B., Goguen, J.E., Bradley, J.W., Turka, L.A., Cho, S.I., Milford, E.L. Transplant. Proc. (1989) [Pubmed]
  36. Medical researchers and the media. Attitudes toward public dissemination of research. Wilkes, M.S., Kravitz, R.L. JAMA (1992) [Pubmed]
  37. Maternal heat exposure and neural tube defects. Milunsky, A., Ulcickas, M., Rothman, K.J., Willett, W., Jick, S.S., Jick, H. JAMA (1992) [Pubmed]
  38. Expression of functional human Epstein-Barr virus/C3d receptor ([CR2] CD21) on insulinoma cell line. Induction of tumor rejection but not diabetes in syngeneic rats. Carel, J.C., Holers, V.M., Chick, W.L., Littman, D., Lacy, P.E. Diabetes (1991) [Pubmed]
  39. Hepatic retransplantation in New England--a regional experience and survival model. Powelson, J.A., Cosimi, A.B., Lewis, W.D., Rohrer, R.J., Freeman, R.B., Vacanti, J.P., Jonas, M., Lorber, M.I., Marks, W.H., Bradley, J. Transplantation (1993) [Pubmed]
  40. Evaluation of serum gentamicin assay procedures for a clinical microbiology laboratory. Lantz, C.H., Lawrie, D.J., Witebsky, F.G., MacLowry, J.D. J. Clin. Microbiol. (1980) [Pubmed]
  41. Association between sucrase-isomaltase and p53 expression in colorectal cancer. Lise, M., Loda, M., Fiorentino, M., Mercurio, A.M., Summerhayes, I.C., Lavin, P.T., Jessup, J.M. Ann. Surg. Oncol. (1997) [Pubmed]
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