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Gene Review

Cpt1b  -  carnitine palmitoyltransferase 1b, muscle

Mus musculus

Synonyms: CPT I, CPT1-M, CPTI-M, Carnitine O-palmitoyltransferase 1, muscle isoform, Carnitine O-palmitoyltransferase I, muscle isoform, ...
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Disease relevance of Cpt1b


High impact information on Cpt1b


Biological context of Cpt1b


Anatomical context of Cpt1b

  • Here we show that Cpt1b transcripts are first and temporally detected at the 2-cell stage and reappear at the morula and blastocyst stage [5].
  • These results show that transcription of both Cpt1b and Cpt2 is triggered at the morula stage, concomitantly with known increasing profiles of oxygen uptake and fatty acids oxidation [5].
  • Similarly to etomoxir, addition of 20 microM C(2)-ceramide to C2C12 myotubes for 3, 6 and 9 h resulted in increased UCP-3 and M-CPT-I mRNA levels [7].

Associations of Cpt1b with chemical compounds


  1. Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy. Cabrero, A., Merlos, M., Laguna, J.C., Carrera, M.V. J. Lipid Res. (2003) [Pubmed]
  2. Stearoyl-CoA Desaturase-1 Mediates the Pro-lipogenic Effects of Dietary Saturated Fat. Sampath, H., Miyazaki, M., Dobrzyn, A., Ntambi, J.M. J. Biol. Chem. (2007) [Pubmed]
  3. The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver. Tien, E.S., Matsui, K., Moore, R., Negishi, M. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  4. The gene encoding muscle-type carnitine palmitoyltransferase I: comparison of the 5'-upstream region of human and rodent genes. Yamazaki, N., Yamanaka, Y., Hashimoto, Y., Hiramatsu, T., Shinohara, Y., Terada, H. J. Biochem. (2003) [Pubmed]
  5. Single-cell quantitative RT-PCR analysis of Cpt1b and Cpt2 gene expression in mouse antral oocytes and in preimplantation embryos. Gentile, L., Monti, M., Sebastiano, V., Merico, V., Nicolai, R., Calvani, M., Garagna, S., Redi, C.A., Zuccotti, M. Cytogenet. Genome Res. (2004) [Pubmed]
  6. Effect of Genistein with Carnitine Administration on Lipid Parameters and Obesity in C57Bl/6J Mice Fed a High-Fat Diet. Yang, J.Y., Lee, S.J., Park, H.W., Cha, Y.S. Journal of medicinal food (2006) [Pubmed]
  7. Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment. Cabrero, A., Alegret, M., Sánchez, R., Adzet, T., Laguna, J.C., Vázquez, M. Biochim. Biophys. Acta (2001) [Pubmed]
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