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Gene Review

Aig1  -  androgen-induced 1

Mus musculus

Synonyms: 1500031O19Rik, AIG-1, AV064870, AW413422, Androgen-induced gene 1 protein, ...
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Disease relevance of Aig1


High impact information on Aig1

  • In the androgen-induced destruction of the mammary rudiments of 14 day male mouse fetuses, the hormone acts directly only on the mesenchyme, which then condenses around the epithelial gland buds and--in some unknown way--causes their necrosis [6].
  • However, androgen-induced declines in circulating HDL-C should not automatically be assumed to be proatherogenic, because these declines may instead reflect accelerated reverse cholesterol transport [7].
  • Thus, it is clear that the androgen-induced growth of SC-3 cells is mediated in an autocrine manner by AIGF, which is secreted by the tumor cells themselves in response to hormonal stimuli [8].
  • To identify the regulatory mechanism(s) underlying this strain variation in Adh-1 transcription in the B6 and B6.S kidney, liver, and androgen-induced kidney [9].
  • Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells [10].

Chemical compound and disease context of Aig1


Biological context of Aig1


Anatomical context of Aig1


Associations of Aig1 with chemical compounds


Regulatory relationships of Aig1


Other interactions of Aig1


Analytical, diagnostic and therapeutic context of Aig1


  1. PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Xu, L.L., Shi, Y., Petrovics, G., Sun, C., Makarem, M., Zhang, W., Sesterhenn, I.A., McLeod, D.G., Sun, L., Moul, J.W., Srivastava, S. Cancer Res. (2003) [Pubmed]
  2. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. Wong, C., Kelce, W.R., Sar, M., Wilson, E.M. J. Biol. Chem. (1995) [Pubmed]
  3. Molecular cloning of TA16, a transcriptional repressor that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells. Fan, W., Ma, J.X., Cheng, L., Norris, J.S. Mol. Endocrinol. (1997) [Pubmed]
  4. Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5alpha-dihydrotestosterone. Schneider, C.P., Schwacha, M.G., Samy, T.S., Bland, K.I., Chaudry, I.H. J. Appl. Physiol. (2003) [Pubmed]
  5. Characterization of beta-adrenergic receptor subtypes in androgen-induced mouse kidney hypertrophy using a new high-affinity ligand, [125I]iodocyanopindolol. Petrovic, S.L., Engel, G., Haugland, R.P., Dowben, R.M. Biochim. Biophys. Acta (1983) [Pubmed]
  6. Specificity of tissue interaction and origin of mesenchymal cells in the androgen response of the embryonic mammary gland. Dürnberger, H., Kratochwil, K. Cell (1980) [Pubmed]
  7. Androgens and coronary artery disease. Wu, F.C., von Eckardstein, A. Endocr. Rev. (2003) [Pubmed]
  8. Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Tanaka, A., Miyamoto, K., Minamino, N., Takeda, M., Sato, B., Matsuo, H., Matsumoto, K. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Tissue-specific genetic variation in the level of mouse alcohol dehydrogenase is controlled transcriptionally in kidney and posttranscriptionally in liver. Tussey, L., Felder, M.R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Berger, R., Febbo, P.G., Majumder, P.K., Zhao, J.J., Mukherjee, S., Signoretti, S., Campbell, K.T., Sellers, W.R., Roberts, T.M., Loda, M., Golub, T.R., Hahn, W.C. Cancer Res. (2004) [Pubmed]
  11. Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter. List, H.J., Smith, C.L., Rodriguez, O., Danielsen, M., Riegel, A.T. Exp. Cell Res. (1999) [Pubmed]
  12. Interaction of androgen-induced autocrine heparin-binding growth factor with fibroblast growth factor receptor on androgen-dependent Shionogi carcinoma 115 cells. Nonomura, N., Lu, J., Tanaka, A., Yamanishi, H., Sato, B., Sonoda, T., Matsumoto, K. Cancer Res. (1990) [Pubmed]
  13. Hyaluronan is a prerequisite for ductal branching morphogenesis. Gakunga, P., Frost, G., Shuster, S., Cunha, G., Formby, B., Stern, R. Development (1997) [Pubmed]
  14. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., Nakamura, T., Tochino, Y., Funahashi, T., Matsuzawa, Y. Diabetes (2002) [Pubmed]
  15. Relationship between androgen-induced cell proliferation and sensitivity to exogenous growth factors. Judge, S.M., Kanter, A.M. Mol. Endocrinol. (1988) [Pubmed]
  16. Paracrine growth stimulation of androgen-responsive Shionogi Carcinoma 115 by its autonomous subline (Chiba Subline 2). Furuya, Y., Sato, N., Akakura, K., Ichikawa, T., Suzuki, N., Sato, R., Shimazaki, J. Cancer Res. (1990) [Pubmed]
  17. Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Gao, J., Arnold, J.T., Isaacs, J.T. Cancer Res. (2001) [Pubmed]
  18. Inhibitory effects of transforming growth factor-beta 1 on androgen-induced development of neonatal mouse seminal vesicles in vitro. Tanji, N., Tsuji, M., Terada, N., Takeuchi, M., Cunha, G.R. Endocrinology (1994) [Pubmed]
  19. A fetal rat urogenital sinus mesenchymal cell line (rUGM): accelerated growth and conferral of androgen-induced growth responsiveness upon a human bladder cancer epithelial cell line in vivo. Zhau, H.E., Hong, S.J., Chung, L.W. Int. J. Cancer (1994) [Pubmed]
  20. Growth-stimulatory effect of androgen-induced autocrine growth factor(s) secreted from Shionogi carcinoma 115 cells on androgen-unresponsive cancer cells in a paracrine mechanism. Nonomura, N., Nakamura, N., Uchida, N., Noguchi, S., Sato, B., Sonoda, T., Matsumoto, K. Cancer Res. (1988) [Pubmed]
  21. Inhibitory and stimulatory effects of glucocorticoid on androgen-induced growth of murine Shionogi carcinoma 115 in vivo and in cell culture. Hiraoka, D., Nakamura, N., Nishizawa, Y., Uchida, N., Noguchi, S., Matsumoto, K., Sato, B. Cancer Res. (1987) [Pubmed]
  22. Proliferative response of mouse seminal vesicle epithelium to androgen and estrogen, assayed by incorporation of [125I]iododeoxyuridine. Okamoto, S., Ogasawara, Y., Yamane, T., Kitamura, Y., Matsumoto, K. Endocrinology (1982) [Pubmed]
  23. A role for heparan sulfate in androgen-induced deoxyribonucleic acid synthesis of mouse mammary carcinoma (Shionogi carcinoma 115)-derived SC-3 cells. Sumitani, S., Kasayama, S., Sato, B. Endocrinology (1993) [Pubmed]
  24. Transforming activity of a newly cloned androgen-induced growth factor. Kouhara, H., Koga, M., Kasayama, S., Tanaka, A., Kishimoto, T., Sato, B. Oncogene (1994) [Pubmed]
  25. Down-regulation of AP1 activities after polarization of vas deferens epithelial cells correlates with androgen-induced gene expression. Darne, C., Martinez, A., Lallemand, D., Morel, L., Jean, C., Saru, J.P., Schmid, H.P., Manin, M. J. Steroid Biochem. Mol. Biol. (2000) [Pubmed]
  26. Activation of androgen receptor in epidermal growth factor modulation of fetal mouse sexual differentiation. Gupta, C., Chandorkar, A., Nguyen, A.P. Mol. Cell. Endocrinol. (1996) [Pubmed]
  27. Modulation of androgen receptor (AR)-mediated transcriptional activity by EGF in the developing mouse reproductive tract primary cells. Gupta, C. Mol. Cell. Endocrinol. (1999) [Pubmed]
  28. Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Heemers, H., Vanderhoydonc, F., Roskams, T., Shechter, I., Heyns, W., Verhoeven, G., Swinnen, J.V. Mol. Cell. Endocrinol. (2003) [Pubmed]
  29. Biosynthesis of the major urinary proteins in mouse liver: a biochemical genetic study. Berger, F.G., Szoka, P. Biochem. Genet. (1981) [Pubmed]
  30. Testosterone-induced growth of S115 mouse mammary tumor cells is dependent on heparan sulfate. Borgenström, M., Tienhaara, A., Spillmann, D., Salmivirta, M., Jalkanen, M. Exp. Cell Res. (2001) [Pubmed]
  31. Epithelial-mesenchymal interactions in prostatic development. II. Biochemical observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder. Neubauer, B.L., Chung, L.W., McCormick, K.A., Taguchi, O., Thompson, T.C., Cunha, G.R. J. Cell Biol. (1983) [Pubmed]
  32. Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney. Persson, L., Seely, J.E., Pegg, A.E. Biochemistry (1984) [Pubmed]
  33. Chronic activity of ectopic type 1 fibroblast growth factor receptor tyrosine kinase in prostate epithelium results in hyperplasia accompanied by intraepithelial neoplasia. Wang, F., McKeehan, K., Yu, C., Ittmann, M., McKeehan, W.L. Prostate (2004) [Pubmed]
  34. Whole-mount autoradiography study of DNA synthetic activity during postnatal development and androgen-induced regeneration in the mouse prostate. Sugimura, Y., Cunha, G.R., Donjacour, A.A., Bigsby, R.M., Brody, J.R. Biol. Reprod. (1986) [Pubmed]
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