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Gene Review

Foxi1  -  forkhead box I1

Mus musculus

Synonyms: 5830401E05Rik, FREAC6, Fkh10, Forkhead box protein I1, HFH-3, ...
 
 
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Disease relevance of Foxi1

 

High impact information on Foxi1

 

Biological context of Foxi1

 

Anatomical context of Foxi1

  • Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice [3].
  • While Foxi1 is expressed in the entire otic vesicle at E9.5, it becomes gradually restricted to the endolymphatic duct/sac epithelium and at E16.5 Foxi1 expression in the inner ear is confined to this epithelium [3].
  • Postnatally, inner ears of Foxi1(-/-) mice are extremely expanded, and large irregular cavities, compressing the cerebellum and the otherwise normal middle ear, have replaced the delicate compartments of the wild-type inner ear [3].
  • 5. These results suggest that the mouse Foxi class genes may play important roles, both during cranial placode specification and in later development of individual cranial sensory structures and other organs derived from the cranial ectoderm [5].
 

Associations of Foxi1 with chemical compounds

  • These patterns contrasted with the later (from E15.5) and progressive expression of IC-specific a4, B1, G3, and C2 subunits, after the induction of the forkhead transcription factor Foxi1 [6].
 

Other interactions of Foxi1

References

  1. Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. Blomqvist, S.R., Vidarsson, H., Fitzgerald, S., Johansson, B.R., Ollerstam, A., Brown, R., Persson, A.E., Bergström G, G., Enerbäck, S. J. Clin. Invest. (2004) [Pubmed]
  2. The winged helix transcription factor Fkh10 is required for normal development of the inner ear. Hulander, M., Wurst, W., Carlsson, P., Enerbäck, S. Nat. Genet. (1998) [Pubmed]
  3. Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Hulander, M., Kiernan, A.E., Blomqvist, S.R., Carlsson, P., Samuelsson, E.J., Johansson, B.R., Steel, K.P., Enerbäck, S. Development (2003) [Pubmed]
  4. The forkhead transcription factor Foxi1 directly activates the AE4 promoter. Kurth, I., Hentschke, M., Hentschke, S., Borgmeyer, U., Gal, A., Hübner, C.A. Biochem. J. (2006) [Pubmed]
  5. Expression of mouse Foxi class genes in early craniofacial development. Ohyama, T., Groves, A.K. Dev. Dyn. (2004) [Pubmed]
  6. Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. Jouret, F., Auzanneau, C., Debaix, H., Wada, G.H., Pretto, C., Marbaix, E., Karet, F.E., Courtoy, P.J., Devuyst, O. J. Am. Soc. Nephrol. (2005) [Pubmed]
  7. Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. Pauley, S., Lai, E., Fritzsch, B. Dev. Dyn. (2006) [Pubmed]
 
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