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Gene Review

FOXI1  -  forkhead box I1

Homo sapiens

Synonyms: FKH10, FKHL10, FREAC-6, FREAC6, Forkhead box protein I1, ...
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High impact information on FOXI1

  • These findings implicate Fkh10 as an early regulator necessary for development of both cochlea and vestibulum and identify its human homologue FKHL10 as a previously unknown candidate deafness gene at 5q34 [1].
  • Using transfection experiments, we have identified a Foxi1 binding cis-element in the ATP6V1B1 (encoding the B1-subunit) promoter that is critical for reporter gene activation [2].
  • Foxi1 appears to be required for the expression of the B1-subunit of the vacuolar H(+)-ATPase proton pump and for carbonic anhydrase II as well as the chloride/bicarbonate transporter pendrin [2].
  • As a consequence of defect Foxi1-dependent epididymal sperm maturation, we demonstrate that spermatozoa from Foxi1 null males fail to reach the female genital tract in sufficient number to allow fertilization [2].
  • We have identified Foxi1 as an important regulator of gene expression in narrow and clear cells-the major proton secretory cells of epididymal epithelia [2].

Biological context of FOXI1


Anatomical context of FOXI1


  1. The winged helix transcription factor Fkh10 is required for normal development of the inner ear. Hulander, M., Wurst, W., Carlsson, P., Enerbäck, S. Nat. Genet. (1998) [Pubmed]
  2. Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility. Blomqvist, S.R., Vidarsson, H., Söder, O., Enerbäck, S. EMBO J. (2006) [Pubmed]
  3. The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney. Overdier, D.G., Ye, H., Peterson, R.S., Clevidence, D.E., Costa, R.H. J. Biol. Chem. (1997) [Pubmed]
  4. Phylogenetic relationships of North American garter snakes (Thamnophis) based on four mitochondrial genes: how much DNA sequence is enough? de Queiroz, A., Lawson, R., Lemos-Espinal, J.A. Mol. Phylogenet. Evol. (2002) [Pubmed]
  5. Identification of the elements regulating the expression of the phospholipase C delta1. Kim, H., Kim, J.Y., Kim, K.A., Lim, Y., Kim, Y.H., Huh, P.W., Lee, K.H., Han, H., Wang, Y.P., Rha, H.K. Mol. Cells (2002) [Pubmed]
  6. Cathepsin B containing cells in the rabbit mesentery during invasion of V2 carcinoma cells. Graf, F.M., Haemmerli, G., Sträuli, P. Histochemistry (1984) [Pubmed]
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