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GDF10  -  growth differentiation factor 10

Homo sapiens

Synonyms: BIP, BMP-3B, BMP-3b, BMP3B, Bone morphogenetic protein 3B, ...
 
 
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Disease relevance of GDF10

 

High impact information on GDF10

 

Biological context of GDF10

  • Because four TCF/LEF-binding sites were identified within human GDF10 promoter, comparative genomics analyses on GDF10 orthologs were further performed [3].
  • The human BMP-3b gene is composed of 3 exons and spans approximately 13 kilobases of DNA [4].
  • Southern blot analysis revealed that the BMP-3b gene is situated in a single locus of chromosome 10 [4].
  • Cloned human BMP-3b cDNA with a size of 2632 base pairs encodes a 478 amino acid precursor protein sharing 83% identity with rat BMP-3b [4].
  • Growth and differentiation factor-10 (GDF-10) mRNA transcripts were expressed in ossicles with a distinctly chondrogenic phase, but its expression was greater in ossicles generated in porous hydroxyapatites, in which bone formation is not via a chondrogenic phase, but is rather intramembranous, without expression of type II collagen mRNA [5].
 

Anatomical context of GDF10

 

Regulatory relationships of GDF10

  • The presence of BMPs in brain is not well studied, but preliminary in situ data indicate that the BMP relatives growth/differentiation factor (GDF)-1 and GDF-10 are distinctly but differentially expressed at high levels in neurons expressing BMPR-II and ActR-I [6].
 

Other interactions of GDF10

  • Among the 171 genes studied (241 probes), limiting the selection of differentially expressed genes to a significant value (p < 0.05), and a differential ratio of expression > 1.6, only four genes, namely IL-32, CCL2, PF4F1 and GDF10 were found to be differentially expressed [7].
  • BMP-3b (also termed GDF-10) is a novel BMP-3 related protein recently discovered in rat femur tissue by molecular cloning [4].
  • Here, we demonstrate that the BMP3b and BMP6 genes are common targets of epigenetic inactivation in NSCLC, and that they are significantly more likely to be concurrently inactivated (P=0.009) [2].

References

  1. Bone morphogenetic protein 3B silencing in non-small-cell lung cancer. Dai, Z., Popkie, A.P., Zhu, W.G., Timmers, C.D., Raval, A., Tannehill-Gregg, S., Morrison, C.D., Auer, H., Kratzke, R.A., Niehans, G., Amatschek, S., Sommergruber, W., Leone, G.W., Rosol, T., Otterson, G.A., Plass, C. Oncogene (2004) [Pubmed]
  2. Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer. Kraunz, K.S., Nelson, H.H., Liu, M., Wiencke, J.K., Kelsey, K.T. Br. J. Cancer (2005) [Pubmed]
  3. Comparative integromics on BMP/GDF family. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  4. cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). Hino, J., Takao, M., Takeshita, N., Konno, Y., Nishizawa, T., Matsuo, H., Kangawa, K. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  5. Induction of endochondral bone formation by recombinant human transforming growth factor-beta2 in the baboon (Papio ursinus). Ripamonti, U., Crooks, J., Matsaba, T., Tasker, J. Growth Factors (2000) [Pubmed]
  6. Bone morphogenetic proteins and their receptors: potential functions in the brain. Ebendal, T., Bengtsson, H., Söderström, S. J. Neurosci. Res. (1998) [Pubmed]
  7. Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes. Cagnard, N., Letourneur, F., Essabbani, A., Devauchelle, V., Mistou, S., Rapinat, A., Decraene, C., Fournier, C., Chiocchia, G. Eur. Cytokine Netw. (2005) [Pubmed]
 
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