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Gene Review

EhV2gp58  -  ORF 57

Equid herpesvirus 2

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Disease relevance of EhV2gp58


High impact information on EhV2gp58


Chemical compound and disease context of EhV2gp58

  • The disrupted viral genome, Bac36-Delta57, did not express ORF57, ORF59, K8alpha, K8.1, or a higher level of polyadenylated nuclear RNA after butyrate induction and could not be induced to produce infectious viruses in the presence of valproic acid, a histone deacetylase inhibitor and a novel KSHV lytic cycle inducer [5].

Biological context of EhV2gp58


Regulatory relationships of EhV2gp58

  • The expression from some (e.g., nut-1) but not all (e.g., tk) ORF 50-responsive promoters can be synergistically enhanced by coexpression of ORF 50 and ORF 57 [6].

Analytical, diagnostic and therapeutic context of EhV2gp58


  1. Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA. Boyne, J.R., Whitehouse, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Structural and Functional Analyses of Kaposi Sarcoma-associated Herpesvirus ORF57 Nuclear Localization Signals in Living Cells. Majerciak, V., Yamanegi, K., Nie, S.H., Zheng, Z.M. J. Biol. Chem. (2006) [Pubmed]
  3. Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Han, Z., Swaminathan, S. J. Virol. (2006) [Pubmed]
  4. The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor. Malik, P., Blackbourn, D.J., Clements, J.B. J. Biol. Chem. (2004) [Pubmed]
  5. Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus. Majerciak, V., Pripuzova, N., McCoy, J.P., Gao, S.J., Zheng, Z.M. J. Virol. (2007) [Pubmed]
  6. Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities. Kirshner, J.R., Lukac, D.M., Chang, J., Ganem, D. J. Virol. (2000) [Pubmed]
  7. DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. Lukac, D.M., Garibyan, L., Kirshner, J.R., Palmeri, D., Ganem, D. J. Virol. (2001) [Pubmed]
  8. Gene Structure and Expression of Kaposi's Sarcoma-Associated Herpesvirus ORF56, ORF57, ORF58, and ORF59. Majerciak, V., Yamanegi, K., Zheng, Z.M. J. Virol. (2006) [Pubmed]
  9. Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteins. Malik, P., Blackbourn, D.J., Cheng, M.F., Hayward, G.S., Clements, J.B. J. Gen. Virol. (2004) [Pubmed]
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