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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

N  -  nucleoprotein

Viral hemorrhagic septicemia virus Fil3

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Disease relevance of N


High impact information on N


Biological context of N

  • VHSV N gene amplification was more efficient and more sensitive than the VHSV G amplicon [6].
  • Sequence analysis of the entire nucleoprotein and glycoprotein genes revealed the virus was a member of the North American genotype of VHSV; however, the isolate was sufficiently distinct to be considered a separate sublineage, suggesting its origin may have been from marine species inhabiting the eastern coastal areas of the USA or Canada [7].
  • Minigenome constructs were expressed only after cotransfection with a set of helper plasmids (N, P and L) all originated from one virus [3].
  • A ribonuclease (RNase) protection assay (RPA) has been used to detect nucleotide sequence variation within the nucleoprotein gene of 39 viral haemorrhagic septicaemia virus (VHSV) isolates of European marine origin [8].

Analytical, diagnostic and therapeutic context of N

  • That Nx protein is antigenically related to the nucleoprotein of purified virus was shown by its reaction with four anti-nucleoprotein monoclonal antibodies (at least 3 of them reacting non competitively against different epitopes) and by immunoprecipitation with polyvalent international reference sera [9].


  1. In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx. Caipang, C.M., Hirono, I., Aoki, T. Virology (2003) [Pubmed]
  2. An RNA-binding domain in the viral haemorrhagic septicaemia virus nucleoprotein. Said, T., Bruley, H., Lamoureux, A., Brémont, M. J. Gen. Virol. (1998) [Pubmed]
  3. Recognition of cis-acting elements of infectious haematopoietic necrosis virus and viral hemorrhagic septicemia virus by homologous and heterologous helper proteins. Hoffmann, B., Schütze, H., Mettenleiter, T.C. Virus Res. (2003) [Pubmed]
  4. Genetic population structure of marine viral haemorrhagic septicaemia virus (VHSV). Snow, M., Bain, N., Black, J., Taupin, V., Cunningham, C.O., King, J.A., Skall, H.F., Raynard, R.S. Dis. Aquat. Org. (2004) [Pubmed]
  5. The in vitro infection of the hematopoietic stroma of trout kidney by hemorrhagic septicemia rhabdovirus. Diago, M.L., Estepa, A., López-Fierro, P., Villena, A., Coll, J.M. Viral Immunol. (1993) [Pubmed]
  6. Rapid detection and quantitation of viral hemorrhagic septicemia virus in experimentally challenged rainbow trout by real-time RT-PCR. Chico, V., Gomez, N., Estepa, A., Perez, L. J. Virol. Methods (2006) [Pubmed]
  7. Isolation of viral haemorrhagic septicaemia virus from muskellunge, Esox masquinongy (Mitchill), in Lake St Clair, Michigan, USA reveals a new sublineage of the North American genotype. Elsayed, E., Faisal, M., Thomas, M., Whelan, G., Batts, W., Winton, J. J. Fish Dis. (2006) [Pubmed]
  8. Analysis of the nucleoprotein gene identifies distinct lineages of viral haemorrhagic septicaemia virus within the European marine environment. Snow, M., Cunningham, C.O., Melvin, W.T., Kurath, G. Virus Res. (1999) [Pubmed]
  9. The free nucleocapsids of the viral haemorrhagic septicaemia virus contain two antigenically related nucleoproteins. Basurco, B., Sanz, F., Marcotegui, M.A., Coll, J.M. Arch. Virol. (1991) [Pubmed]
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