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Gene Review

G  -  glycoprotein

Viral hemorrhagic septicemia virus Fil3

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Disease relevance of G


High impact information on G


Chemical compound and disease context of G


Biological context of G

  • VHSV N gene amplification was more efficient and more sensitive than the VHSV G amplicon [10].
  • The genome comprises 11158 bases and contains six long open reading frames encoding the nucleoprotein N, phosphoprotein P, matrix protein M, glycoprotein G, nonstructural viral protein NV, and polymerase L. Genes are arranged in the order 3'-N-P-M-G-NV-L-5'. The exact 3' and 5' ends were determined after RNA-oligonucleotide ligation or RACE [11].
  • Sequence analysis of the entire nucleoprotein and glycoprotein genes revealed the virus was a member of the North American genotype of VHSV; however, the isolate was sufficiently distinct to be considered a separate sublineage, suggesting its origin may have been from marine species inhabiting the eastern coastal areas of the USA or Canada [12].
  • Sequence comparisons identified no difference in the consensus sequence of the glycoprotein gene following in vivo passage [13].
  • When transfection was performed in the presence of monoclonal antibodies (Mab) to the glycoprotein, the production of interferon mRNA transcripts was reduced by over 50% [9].

Anatomical context of G


Associations of G with chemical compounds

  • Only native, denatured or recombinant fragment G4 viral glycoprotein G showed PS-binding [18].

Analytical, diagnostic and therapeutic context of G


  1. In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx. Caipang, C.M., Hirono, I., Aoki, T. Virology (2003) [Pubmed]
  2. Combined DNA immunization with the glycoprotein gene of viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus induces double-specific protective immunity and nonspecific response in rainbow trout. Boudinot, P., Blanco, M., de Kinkelin, P., Benmansour, A. Virology (1998) [Pubmed]
  3. Characterization of intramolecular disulfide bonds and secondary modifications of the glycoprotein from viral hemorrhagic septicemia virus, a fish rhabdovirus. Einer-Jensen, K., Krogh, T.N., Roepstorff, P., Lorenzen, N. J. Virol. (1998) [Pubmed]
  4. A recombinant viral haemorrhagic septicaemia virus glycoprotein expressed in insect cells induces protective immunity in rainbow trout. Lecocq-Xhonneux, F., Thiry, M., Dheur, I., Rossius, M., Vanderheijden, N., Martial, J., de Kinkelin, P. J. Gen. Virol. (1994) [Pubmed]
  5. Recombinant infectious hematopoietic necrosis virus and viral hemorrhagic septicemia virus glycoprotein epitopes expressed in Aeromonas salmonicida induce protective immunity in rainbow trout (Oncorhynchus mykiss). Noonan, B., Enzmann, P.J., Trust, T.J. Appl. Environ. Microbiol. (1995) [Pubmed]
  6. Phylogeography of infectious haematopoietic necrosis virus in North America. Kurath, G., Garver, K.A., Troyer, R.M., Emmenegger, E.J., Einer-Jensen, K., Anderson, E.D. J. Gen. Virol. (2003) [Pubmed]
  7. Pepscan mapping and fusion-related properties of the major phosphatidylserine-binding domain of the glycoprotein of viral hemorrhagic septicemia virus, a salmonid rhabdovirus. Estepa, A., Coll, J.M. Virology (1996) [Pubmed]
  8. Co-injection of interleukin 8 with the glycoprotein gene from viral haemorrhagic septicemia virus (VHSV) modulates the cytokine response in rainbow trout (Oncorhynchus mykiss). Jimenez, N., Coll, J., Salguero, F.J., Tafalla, C. Vaccine (2006) [Pubmed]
  9. Expression of the glycoprotein of viral haemorrhagic septicaemia virus (VHSV) on the surface of the fish cell line RTG-P1 induces type 1 interferon expression in neighbouring cells. Acosta, F., Collet, B., Lorenzen, N., Ellis, A.E. Fish Shellfish Immunol. (2006) [Pubmed]
  10. Rapid detection and quantitation of viral hemorrhagic septicemia virus in experimentally challenged rainbow trout by real-time RT-PCR. Chico, V., Gomez, N., Estepa, A., Perez, L. J. Virol. Methods (2006) [Pubmed]
  11. Complete genomic sequence of viral hemorrhagic septicemia virus, a fish rhabdovirus. Schütze, H., Mundt, E., Mettenleiter, T.C. Virus Genes (1999) [Pubmed]
  12. Isolation of viral haemorrhagic septicaemia virus from muskellunge, Esox masquinongy (Mitchill), in Lake St Clair, Michigan, USA reveals a new sublineage of the North American genotype. Elsayed, E., Faisal, M., Thomas, M., Whelan, G., Batts, W., Winton, J. J. Fish Dis. (2006) [Pubmed]
  13. Virulence and nucleotide sequence analysis of marine viral haemorrhagic septicaemia virus following in vivo passage in rainbow trout Onchorhynchus mykiss. Snow, M., Cunningham, C.O. Dis. Aquat. Org. (2000) [Pubmed]
  14. Stimulation of adherent cells by addition of purified proteins of viral hemorrhagic septicemia virus to trout kidney cell cultures. Estepa, A., Basurco, B., Sanz, F., Coll, J.M. Viral Immunol. (1991) [Pubmed]
  15. Analysis of DNA-vaccinated fish reveals viral antigen in muscle, kidney and thymus, and transient histopathologic changes. Garver, K.A., Conway, C.M., Elliott, D.G., Kurath, G. Mar. Biotechnol. (2005) [Pubmed]
  16. Multiplication of VHS virus in insect cells. Lorenzen, N., Olesen, N.J. Vet. Res. (1995) [Pubmed]
  17. Susceptibility of trout kidney macrophages to viral hemorrhagic septicemia virus. Estepa, A., Frías, D., Coll, J.M. Viral Immunol. (1992) [Pubmed]
  18. Synthetic peptides reveal a phospholipid binding domain in the glycoprotein of VHSV, a salmonid rhabdovirus. Coll, J.M. Vet. Res. (1995) [Pubmed]
  19. Comparative immune responses in Japanese flounder, Paralichthys olivaceus after vaccination with viral hemorrhagic septicemia virus (VHSV) recombinant glycoprotein and DNA vaccine using a microarray analysis. Byon, J.Y., Ohira, T., Hirono, I., Aoki, T. Vaccine (2006) [Pubmed]
  20. Purification of the glycoprotein G from viral haemorrhagic septicaemia virus, a fish rhabdovirus, by lectin affinity chromatography. Perez, L., Estepa, A., Coll, J.M. J. Virol. Methods (1998) [Pubmed]
  21. Neutralizing-enhancing monoclonal antibody recognizes the denatured glycoprotein of viral haemorrhagic septicaemia virus. Sanz, F., Coll, J.M. Arch. Virol. (1992) [Pubmed]
  22. Differential diagnosis of fish pathogenic rhabdoviruses by reverse transcriptase-dependent polymerase chain reaction. Bruchhof, B., Marquardt, O., Enzmann, P.J. J. Virol. Methods (1995) [Pubmed]
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