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Gene Review

BNIPL  -  BCL2/adenovirus E1B 19kD interacting...

Homo sapiens

Synonyms: BNIP-S, BNIPL-1, BNIPL-2, BNIPL1, BNIPL2, ...
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Disease relevance of BNIPL

  • We report here the identification of a novel member of BNIPL family, designated Bcl-2/adenovirus E1B 19kDa interacting protein 2 like-2 (BNIPL-2), which interacts with Bcl-2 and Cdc42GAP [1].
  • We propose that BNIPL-2 protein may play an important role in regulation of both pathways for DNA fragmentation and for formation of membrane blebs in apoptotic cells [1].
  • The overexpression of BNIPL-2 promotes the invasion and metastasis of MHCC97-L cells [2].
  • In this study, a full-length human BNIPL-2 (Bcl-2/adenovirus E1B 19 kDa interacting protein 2 like-2) cDNA was transfected into human hepatocellular carcinoma cells with low metastatic potential (MHCC97-L) [2].

High impact information on BNIPL

  • The BNIP-S gene encodes two protein isoforms; the longer protein (BNIP-Salpha) contains a complete BNIP-2 and Cdc42GAP Homology (BCH) domain, a novel protein domain that we recently identified, whereas its shorter variant (BNIP-Sbeta) lacks the full BCH domain as a result of an alternative RNA splicing that introduces a nonsense intron [3].
  • The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER [4].
  • Colony formation assay and cell proliferation test suggest that overexpression of BNIPL could inhibit the growth of BEL-7402 cells [4].
  • We found that the human BNIPL-2 shares homology to human BNIP-2 and also possesses a BNIP-2 and Cdc42GAP homology (BCH) domain [1].
  • Our data showed that BNIPL-2 may be a linker protein located at the front end of Bcl-2 pathway for DNA fragmentation and Cdc42 signaling for morphological changes during apoptosis [1].

Biological context of BNIPL


Anatomical context of BNIPL


Associations of BNIPL with chemical compounds


Other interactions of BNIPL

  • AIM: Bcl-2/adenovirus E1B 19 ku interacting protein 2-like (BNIPL-2) is a novel protein recently identified in our laboratory [5].

Analytical, diagnostic and therapeutic context of BNIPL


  1. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. Qin, W., Hu, J., Guo, M., Xu, J., Li, J., Yao, G., Zhou, X., Jiang, H., Zhang, P., Shen, L., Wan, D., Gu, J. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  2. BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells. Xie, L., Qin, W., Li, J., He, X., Zhang, H., Yao, G., Shu, H., Yao, M., Wan, D., Gu, J. Oncol. Rep. (2007) [Pubmed]
  3. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. Zhou, Y.T., Soh, U.J., Shang, X., Guy, G.R., Low, B.C. J. Biol. Chem. (2002) [Pubmed]
  4. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. Shen, L., Hu, J., Lu, H., Wu, M., Qin, W., Wan, D., Li, Y.Y., Gu, J. FEBS Lett. (2003) [Pubmed]
  5. Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2. Xie, L., Qin, W.X., He, X.H., Shu, H.Q., Yao, G.F., Wan, D.F., Gu, J.R. World J. Gastroenterol. (2004) [Pubmed]
  6. cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1. Xie, L., Qin, W.X., Li, J.J., He, X.H., Shu, H.Q., Yao, G.F., Wan, D.F., Gu, J.R. Acta Biochim. Biophys. Sin. (Shanghai) (2005) [Pubmed]
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