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Gene Review

CTNND2  -  catenin (cadherin-associated protein),...

Homo sapiens

Synonyms: Catenin delta-2, Delta-catenin, GT24, NPRAP, Neural plakophilin-related ARM-repeat protein, ...
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Disease relevance of CTNND2


High impact information on CTNND2


Biological context of CTNND2

  • Mutagenesis and peptide competition experiments showed that the association of Erbin with the cadherin-catenin complex was mediated by the interaction of its PDZ domain with the C-terminal PDZ domain-binding motifs (DSWV-COOH) of ARVCF and delta-catenin [5].
  • Delta-catenin is an adherens junction protein involved in cell motility and expressed early in neuronal development [1].
  • By analyzing the same tumor cell clusters using consecutive sections, we showed that an increased delta-catenin immunoreactivity was accompanied by the down-regulation and redistribution of E-cadherin and p120ctn, major cell junction proteins whose inactivation is frequently associated with cancer progression [2].
  • However, our recent analysis of the human genome revealed a consistent association of delta-catenin messenger RNA sequences with malignant cells, although the significance of these findings was unclear [2].
  • We propose that delta-catenin can regulate adhesion molecules to implement the organization of large cellular arrays necessary for tissue morphogenesis [6].

Anatomical context of CTNND2


Physical interactions of CTNND2


Regulatory relationships of CTNND2


Other interactions of CTNND2

  • We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids [8].
  • Analysis of the interactions of the Erbin PDZ domain with synthetic peptides matching the C termini of ARVCF or delta-catenin also demonstrated specific high affinity binding [5].
  • Finally, we showed that endogenous delta-catenin and Erbin co-localized in and co-immunoprecipitated from neurons [5].
  • RESULTS.: DNA copy numbers of PRKAA1, CTNND2 and ERBIN were significantly different from normal controls (P < 0.05) [12].
  • From co-immunoprecipitation analyses, the C-terminal portion of delta-catenin/NPRAP containing the seventh to tenth armadillo repeats was found to be required for interaction with SPHK1 [11].

Analytical, diagnostic and therapeutic context of CTNND2


  1. Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome. Medina, M., Marinescu, R.C., Overhauser, J., Kosik, K.S. Genomics (2000) [Pubmed]
  2. Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer. Lu, Q., Dobbs, L.J., Gregory, C.W., Lanford, G.W., Revelo, M.P., Shappell, S., Chen, Y.H. Hum. Pathol. (2005) [Pubmed]
  3. Delta-catenin at the synaptic-adherens junction. Kosik, K.S., Donahue, C.P., Israely, I., Liu, X., Ochiishi, T. Trends Cell Biol. (2005) [Pubmed]
  4. Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. Martinez, M.C., Ochiishi, T., Majewski, M., Kosik, K.S. J. Cell Biol. (2003) [Pubmed]
  5. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. Laura, R.P., Witt, A.S., Held, H.A., Gerstner, R., Deshayes, K., Koehler, M.F., Kosik, K.S., Sidhu, S.S., Lasky, L.A. J. Biol. Chem. (2002) [Pubmed]
  6. delta-catenin, an adhesive junction-associated protein which promotes cell scattering. Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Peifer, M., Orecchio, L., Kosik, K.S. J. Cell Biol. (1999) [Pubmed]
  7. Regulation of the rapsyn promoter by kaiso and delta-catenin. Rodova, M., Kelly, K.F., VanSaun, M., Daniel, J.M., Werle, M.J. Mol. Cell. Biol. (2004) [Pubmed]
  8. Isolation of human delta-catenin and its binding specificity with presenilin 1. Tanahashi, H., Tabira, T. Neuroreport (1999) [Pubmed]
  9. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. Izawa, I., Nishizawa, M., Ohtakara, K., Inagaki, M. J. Biol. Chem. (2002) [Pubmed]
  10. Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region. Paulson, A.F., Mooney, E., Fang, X., Ji, H., McCrea, P.D. J. Biol. Chem. (2000) [Pubmed]
  11. Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. Fujita, T., Okada, T., Hayashi, S., Jahangeer, S., Miwa, N., Nakamura, S. Biochem. J. (2004) [Pubmed]
  12. Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer. Huang, F.Y., Chiu, P.M., Tam, K.F., Kwok, Y.K., Lau, E.T., Tang, M.H., Ng, T.Y., Liu, V.W., Cheung, A.N., Ngan, H.Y. Gynecol. Oncol. (2006) [Pubmed]
  13. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Zhou, J., Liyanage, U., Medina, M., Ho, C., Simmons, A.D., Lovett, M., Kosik, K.S. Neuroreport (1997) [Pubmed]
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