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Gene Review

AMOT  -  angiomotin

Homo sapiens

Synonyms: Angiomotin, KIAA1071
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Disease relevance of AMOT

  • RESULTS: Breast cancer tissues expressed significantly higher levels of angiomotin transcript, compared with normal mammary tissues (33.1 +/- 11 in normal versus 86.5 +/- 13.7 in tumour tissues, p = 0.003) [1].

High impact information on AMOT


Biological context of AMOT


Anatomical context of AMOT


Associations of AMOT with chemical compounds

  • To study the effect of angiomotin on embryonic angiogenesis, we generated transgenic mice expressing wild-type angiomotin and the C-terminal deletion mutant driven by the endothelial cell-specific receptor tyrosine kinase (TIE) promoter [5].

Other interactions of AMOT

  • This study examined the expression of angiomotin and its analogues, angiomotin-like 1 (L1) and -like 2 (L2) in breast tumour tissues, and analysed their correlation with angiogenesis and clinical outcomes [1].

Analytical, diagnostic and therapeutic context of AMOT

  • Here, we describe a strategy that targets the angiostatin receptor angiomotin (Amot) by DNA vaccination [8].


  1. Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer. Jiang, W.G., Watkins, G., Douglas-Jones, A., Holmgren, L., Mansel, R.E. BMC Cancer (2006) [Pubmed]
  2. A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells. Wells, C.D., Fawcett, J.P., Traweger, A., Yamanaka, Y., Goudreault, M., Elder, K., Kulkarni, S., Gish, G., Virag, C., Lim, C., Colwill, K., Starostine, A., Metalnikov, P., Pawson, T. Cell (2006) [Pubmed]
  3. Hold that line. Angiomotin regulates endothelial cell motility. Zetter, B.R. J. Cell Biol. (2001) [Pubmed]
  4. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. Troyanovsky, B., Levchenko, T., Månsson, G., Matvijenko, O., Holmgren, L. J. Cell Biol. (2001) [Pubmed]
  5. Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin. Levchenko, T., Aase, K., Troyanovsky, B., Bratt, A., Holmgren, L. J. Cell. Sci. (2003) [Pubmed]
  6. p130-Angiomotin associates to actin and controls endothelial cell shape. Ernkvist, M., Aase, K., Ukomadu, C., Wohlschlegel, J., Blackman, R., Veitonmäki, N., Bratt, A., Dutta, A., Holmgren, L. FEBS J. (2006) [Pubmed]
  7. Angiomotin regulates endothelial cell-cell junctions and cell motility. Bratt, A., Birot, O., Sinha, I., Veitonmäki, N., Aase, K., Ernkvist, M., Holmgren, L. J. Biol. Chem. (2005) [Pubmed]
  8. A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth. Holmgren, L., Ambrosino, E., Birot, O., Tullus, C., Veitonmäki, N., Levchenko, T., Carlson, L.M., Musiani, P., Iezzi, M., Curcio, C., Forni, G., Cavallo, F., Kiessling, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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