The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Cd93  -  CD93 antigen

Mus musculus

Synonyms: 6030404G09Rik, AA145088, AA4.1, AW555904, Aa4, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Cd93

  • We studied the developmental potential of two ES cell subpopulations that share the fetal stem cell antigen AA4.1 but differ in expression of the lymphoid marker B220 (CD45R) [1].
  • With the use of anti-Tie-2 monoclonal antibody, its expression was detected in approximately 7% of an HSC population of Kit-positive, Sca-1-positive, lineage-negative or -low, and AA4.1-positive (KSLA) cells [2].
  • We suggest that AA4.1, CD4 and flk-2 are expressed as stage-specific markers on PHSC in cell cycle [3].
  • Human CD93 (known as C1qRp) has been shown to be a phagocytic receptor involved in the in vitro C1q-dependent enhancement of phagocytosis [4].
  • Rat C1qRp is expressed by resting and by activated NK cells, on subpopulations of NKR-P1(+) T cells (NK/T cells), dendritic cells, macrophages and granulocytes, but not by B cells or NKR-P1(-) T cells [5].
 

Biological context of Cd93

  • Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis [4].
  • It is encoded by a single gene on rat chromosome 3q41-q42 and is 67% and 87.5% identical at the amino acid level to human and mouse C1qRp, respectively [5].
  • During embryonic hematopoiesis FLRF is abundantly transcribed in mouse fetal liver HSC (Sca-1+c-kit+AA4.1+Lin- cells), but is not expressed in progenitors (AA4.1-) [6].
 

Anatomical context of Cd93

  • Antigens expressed by stromal cells were detected by AA4.1, our 94.2 antibody, and antibody to the Forsmann antigen, but the most distinguishing characteristics of the lymphocyte-binding stromal cells were production of basement membrane components, laminin and collagen IV, and the extremely low uptake of acetylated low density lipoprotein (LDL) [7].
  • Two hematopoietic differentiation antigens, Ly-6C and AA4.1, are expressed abnormally on NOD bone marrow cells [8].
 

Regulatory relationships of Cd93

  • Similar results were obtained when AA4.1-expressing yolk sac and adult marrow cells that bind wheat germ agglutinin (WGA) were isolated via flow cytometry [9].
 

Other interactions of Cd93

  • All markers with the exception of CD45 and AA4.1 were initially detected in cultures of undifferentiated ES cells [10].

References

  1. Hemato-lymphoid in vivo reconstitution potential of subpopulations derived from in vitro differentiated embryonic stem cells. Potocnik, A.J., Kohler, H., Eichmann, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver. Hsu, H.C., Ema, H., Osawa, M., Nakamura, Y., Suda, T., Nakauchi, H. Blood (2000) [Pubmed]
  3. Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Orlic, D., Fischer, R., Nishikawa, S., Nienhuis, A.W., Bodine, D.M. Blood (1993) [Pubmed]
  4. Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. Norsworthy, P.J., Fossati-Jimack, L., Cortes-Hernandez, J., Taylor, P.R., Bygrave, A.E., Thompson, R.D., Nourshargh, S., Walport, M.J., Botto, M. J. Immunol. (2004) [Pubmed]
  5. Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. Løvik, G., Vaage, J.T., Dissen, E., Szpirer, C., Ryan, J.C., Rolstad, B. Eur. J. Immunol. (2000) [Pubmed]
  6. FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors. Abdullah, J.M., Li, X., Nachtman, R.G., Jurecic, R. Blood Cells Mol. Dis. (2001) [Pubmed]
  7. Relationships between B-lineage lymphocytes and stromal cells in long-term bone marrow cultures. Witte, P.L., Robinson, M., Henley, A., Low, M.G., Stiers, D.L., Perkins, S., Fleischman, R.A., Kincade, P.W. Eur. J. Immunol. (1987) [Pubmed]
  8. Bone marrow abnormalities in the non-obese diabetic mouse. Langmuir, P.B., Bridgett, M.M., Bothwell, A.L., Crispe, I.N. Int. Immunol. (1993) [Pubmed]
  9. Murine yolk sac and bone marrow hematopoietic cells with high proliferative potential display different capacities for producing colony-forming cells ex vivo. Yoder, M.C., Hiatt, K. J. Hematother. Stem Cell Res. (1999) [Pubmed]
  10. In vitro differentiation of embryonic stem cells: immunophenotypic analysis of cultured embryoid bodies. Ling, V., Neben, S. J. Cell. Physiol. (1997) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities