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Gene Review:

DLX6 - distal-less homeobox 6

Homo sapiens

Synonyms: Homeobox protein DLX-6

Nabi, R. et al., Hsu, S.H. et al., Yang, Z. et al., Pfeffer, U. et al., Simeone, A. et al., et al.

Pfeffer, Ferro, Pavia, Trombino, Dell'Eva, Merlo, Levi,

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Disease relevance of DLX6

Dlx5 and Dlx6 are functionally redundant regulators of chondrocyte hypertrophy [1].

Psychiatry related information on DLX6

We have investigated a single nucleotide polymorphism (SNP) in exon 4 of the PCLO gene and a SNP in intron 1 of the DLX6 gene for linkage and association in autistic disorder using both qualitative and quantitative analyses [2].

High impact information on DLX6

The two human genes, DLX5 and DLX6, are closely linked in an inverted convergent configuration in a region of chromosome 7, at 7q22 [3].
A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression [4].
Limb bud mesenchymal cells from Dlx5/6(-/-) embryos show reduced chondrogenesis compared to wild-type littermates, and expression of either Dlx5 or Dlx6 stimulated differentiation of limb bud mesenchymal cells to chondroblasts [1].
Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus [5].
Our analysis of genes that map to this region has led to the identification of the so far unknown first exon of the homeobox gene DLX6, a mammalian homologue of the Drosophila distal-less gene [6].

Biological context of DLX6

No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism [2].
In conclusion, our studies suggest that these two SNPs in DLX6 and PCLO genes are not in linkage disequilibrium with autism [2].
Dlx5- and Dlx6-mediated chondrogenesis: Differential domain requirements for a conserved function [1].

Anatomical context of DLX6

Expression of Dlx5 and Dlx6 during specification of the elbow joint [7].

Other interactions of DLX6

DLX6 and Piccolo (PCLO) at 7q21-q22 are two positional and functional candidate genes in autism [2].
Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development [4].

References

Dlx5- and Dlx6-mediated chondrogenesis: Differential domain requirements for a conserved function. Hsu, S.H., Noamani, B., Abernethy, D.E., Zhu, H., Levi, G., Bendall, A.J. Mech. Dev. (2006) [Pubmed]
No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. Nabi, R., Zhong, H., Serajee, F.J., Huq, A.H. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003) [Pubmed]
Cloning and characterization of two members of the vertebrate Dlx gene family. Simeone, A., Acampora, D., Pannese, M., D'Esposito, M., Stornaiuolo, A., Gulisano, M., Mallamaci, A., Kastury, K., Druck, T., Huebner, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Yang, Z., Liu, N., Lin, S. Dev. Biol. (2001) [Pubmed]
Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus. Robledo, R.F., Lufkin, T. Genesis (2006) [Pubmed]
The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat. Pfeffer, U., Ferro, P., Pavia, V., Trombino, S., Dell'Eva, R., Merlo, G., Levi, G. Int. J. Oncol. (2001) [Pubmed]
Expression of Dlx5 and Dlx6 during specification of the elbow joint. Ferrari, D., Kosher, R.A. Int. J. Dev. Biol. (2006) [Pubmed]

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DLX6	Bos taurus
DLX6	Canis lupus familiaris
dlx6a	Danio rerio
DLX6	Gallus gallus
DLX6	Macaca mulatta
Dlx6	Mus musculus
DLX6	Pan troglodytes
Dlx6	Rattus norvegicus
LOC100494171	Xenopus (Silurana) tropicalis

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