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Gene Review

DLX6  -  distal-less homeobox 6

Homo sapiens

Synonyms: Homeobox protein DLX-6
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Disease relevance of DLX6


Psychiatry related information on DLX6


High impact information on DLX6


Biological context of DLX6


Anatomical context of DLX6


Other interactions of DLX6

  • DLX6 and Piccolo (PCLO) at 7q21-q22 are two positional and functional candidate genes in autism [2].
  • Forced expression of fez induces ectopic expression of dlx2 and dlx6, two genes involved in brain development [4].


  1. Dlx5- and Dlx6-mediated chondrogenesis: Differential domain requirements for a conserved function. Hsu, S.H., Noamani, B., Abernethy, D.E., Zhu, H., Levi, G., Bendall, A.J. Mech. Dev. (2006) [Pubmed]
  2. No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. Nabi, R., Zhong, H., Serajee, F.J., Huq, A.H. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003) [Pubmed]
  3. Cloning and characterization of two members of the vertebrate Dlx gene family. Simeone, A., Acampora, D., Pannese, M., D'Esposito, M., Stornaiuolo, A., Gulisano, M., Mallamaci, A., Kastury, K., Druck, T., Huebner, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Yang, Z., Liu, N., Lin, S. Dev. Biol. (2001) [Pubmed]
  5. Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus. Robledo, R.F., Lufkin, T. Genesis (2006) [Pubmed]
  6. The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat. Pfeffer, U., Ferro, P., Pavia, V., Trombino, S., Dell'Eva, R., Merlo, G., Levi, G. Int. J. Oncol. (2001) [Pubmed]
  7. Expression of Dlx5 and Dlx6 during specification of the elbow joint. Ferrari, D., Kosher, R.A. Int. J. Dev. Biol. (2006) [Pubmed]
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