Disease relevance of Catalase

• Our findings support an important role for peroxisomal catalase in both the development and aging of C. elegans and suggest the utility of the Deltactl-2 mutant as a convenient model for the study of aging and the human diseases acatalasemia and hypocatalasemia [1].
• Gene structure, activity and localization of a catalase from intracellular bacteria in Onchocerca volvulus [2].
• The bacterial catalase from filarial DNA preparations derives from common pseudomonad contaminants and not from Wolbachia endosymbionts [3].
• By amplification and sequencing of 16S rDNA and catalase sequences, we show that filarial DNA samples prepared from nematodes collected under typical conditions are frequently contaminated with Pseudomonas DNA [3].

High impact information on Catalase

• Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans [1].
• H2O2 may mask the effects of other pathogenicity factors of catalase-negative bacteria in the C. elegans infection model [4].
• The peroxisomes of C. elegans were not detectable by cytochemical staining using 3, 3'-diaminobenzidine, a commonly used method depending on the peroxidase activity of peroxisomal catalase at pH 9 in which genuine peroxidases are inactive [5].
• Additionally, there was no obvious catalase in either of two available Wolbachia genome sequences [3].
• This suggests that SOD and catalase do not play a role in the adaptive response against oxidative stress under hyperoxia, at least under these experimental conditions [6].

Biological context of Catalase

• Using genetic mutants, we show that lack of peroxisomal catalase CTL-2 causes a progeric phenotype in C. elegans [1].
• Within the context of studies on the antioxidant enzymes in Onchocerca volvulus, DNA clones encoding catalase (CAT) were isolated from an O. volvulus adult lambda zapII cDNA library [2].

Anatomical context of Catalase

• Catalase activity was barely detectable in A. suum testis [7].
• 3. Catalase activity in adult body wall muscle was similar to that in rat skeletal muscle, but dramatically lower than that in rat liver [7].

References