Disease relevance of cat

• Furthermore, the coding region of zebrafish catalase was introduced into an expression vector, pET-20b(+), and transformed into Escherichia coli expression host BL21(DE3)pLysS [1].

High impact information on cat

• Oxidative stress induced by uranium exposure led to decreases in superoxide dismutase and catalase activity levels as well as total glutathione content in liver extracts [2].
• Catalase, glutathione peroxidase, and superoxide dismutase activities and total glutathione content of hepatic extracts, as well as brain acetylcholinesterase activity and uranium bioaccumulation, were measured [2].
• The deduced amino acid sequence showed high similarity with the sequences of catalase from swine (86.9%), mouse (85.8%), rat (85%), human (83.7%), fruit fly (75.6%), nematode (71.1%), and yeast (58.6%) [1].
• A 60-kDa active catalase protein was expressed and detected by Coomassie blue staining as well as activity staining on polyacrylamide gel followed electrophoresis [1].
• Changes in peroxisomes were visualized by cytochemical staining for catalase activity with diaminobenzidine [3].

Biological context of cat

• Additional alterations at 80 micrograms/liter comprise proliferation of SER in males and progressive fractionation of RER in females, stacking of club-shaped mitochondria, a conspicuous decrease in peroxisomal catalase activity, infiltration of macrophages into the liver parenchyma, and a significant stimulation of hepatocytic mitosis [3].

Anatomical context of cat

• Trout hepatocytes display nuclear inclusions, fractionation and vesiculation of the RER, and an increase in mitochondria, but a decrease of peroxisomes and catalase activity [4].

Associations of cat with chemical compounds

• Oxidative stress was assessed by determining both the production of hydrogen peroxide and by analyzing the activities of the antioxidative enzymes, guajacol peroxidase (POD), catalase (CAT), glutathione peroxidase (GPx), and the glutathione restoring enzyme glutathione reductase (GR) [5].

Analytical, diagnostic and therapeutic context of cat

• Molecular cloning and sequence analysis of the Danio rerio catalase gene [6].

References