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Gene Review

Cat  -  Catalase

Drosophila melanogaster

Synonyms: CAT, CATA, CG6871, CT21282, CatA, ...
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Psychiatry related information on Cat


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Biological context of Cat


Anatomical context of Cat

  • Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity [10].
  • Catalase, an antioxidative enzyme expressed in the cytosol and peroxisomes of Drosophila, was targetted ectopically to the mitochondrial matrix by fusion of a leader peptide derived from ornithine aminotransferase with its N-terminus [10].
  • Because of the presence of catalase as well as by their structural appearance, these organelles are to be identified as microperoxisomes [11].
  • Catalase activity is restricted to the very last stages of oogenesis (stage 13-14) and appears to be located in membrane-bound organelles of the ooplasm which are continuous with the endoplasmic reticulum [11].

Associations of Cat with chemical compounds


Physical interactions of Cat


Regulatory relationships of Cat


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  • Significant increases in the activities of both CuZn-SOD and catalase had no beneficial effect on survivorship in relatively long-lived y w mutant flies and were associated with slightly decreased life spans in wild type flies of the Oregon-R strain [3].
  • Our data show that the expression of the genes encoding known ROS scavengers [superoxide dismutase (SOD) and catalase] is not regulated by dADAR [18].
  • Transcriptional regulation of the Drosophila catalase gene by the DRE/DREF system [17].
  • Spatially, it was ascertained that catalase expression is mostly confined to tissues related to intermediary metabolism, digestive and adipose systems as well as oenocytes [12].
  • 3AT inhibited up to 80% of the catalase activity with concordant small increases in the in vitro activities of sn-glycerol-3-phosphate dehydrogenase, fumarase, and malic enzyme, but with a 16% reduction in the in vivo incorporation of label from [14C]glucose into lipid [19].

Analytical, diagnostic and therapeutic context of Cat


  1. Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Mockett, R.J., Orr, W.C., Rahmandar, J.J., Benes, J.J., Radyuk, S.N., Klichko, V.I., Sohal, R.S. Arch. Biochem. Biophys. (1999) [Pubmed]
  2. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Sun, J., Tower, J. Mol. Cell. Biol. (1999) [Pubmed]
  3. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. Orr, W.C., Mockett, R.J., Benes, J.J., Sohal, R.S. J. Biol. Chem. (2003) [Pubmed]
  4. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. Sohal, R.S., Agarwal, A., Agarwal, S., Orr, W.C. J. Biol. Chem. (1995) [Pubmed]
  5. cDNA and deduced amino acid sequence of Drosophila catalase. Orr, E.C., Bewley, G.C., Orr, W.C. Nucleic Acids Res. (1990) [Pubmed]
  6. Longevity determination genes in Drosophila melanogaster. Aigaki, T., Seong, K.H., Matsuo, T. Mech. Ageing Dev. (2002) [Pubmed]
  7. A putative glutathione peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Missirlis, F., Rahlfs, S., Dimopoulos, N., Bauer, H., Becker, K., Hilliker, A., Phillips, J.P., Jäckle, H. Biol. Chem. (2003) [Pubmed]
  8. The genetics of catalase in Drosophila melanogaster: isolation and characterization of acatalasemic mutants. Mackay, W.J., Bewley, G.C. Genetics (1989) [Pubmed]
  9. Molecular analysis of the Drosophila catalase gene. Orr, W.C., Orr, E.C., Legan, S.K., Sohal, R.S. Arch. Biochem. Biophys. (1996) [Pubmed]
  10. Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. Mockett, R.J., Bayne, A.C., Kwong, L.K., Orr, W.C., Sohal, R.S. Free Radic. Biol. Med. (2003) [Pubmed]
  11. Cytochemistry of late ovarian chambers of Drosophila melanogaster. Giorgi, F., Deri, P. Histochemistry (1976) [Pubmed]
  12. Profiling catalase gene expression in Drosophila melanogaster during development and aging. Klichko, V.I., Radyuk, S.N., Orr, W.C. Arch. Insect Biochem. Physiol. (2004) [Pubmed]
  13. Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster. Sohal, R.S., Arnold, L., Orr, W.C. Mech. Ageing Dev. (1990) [Pubmed]
  14. Genetic variation affecting the expression of catalase in Drosophila melanogaster: correlations with rates of enzyme synthesis and degradation. Bewley, G.C., Laurie-Ahlberg, C.C. Genetics (1984) [Pubmed]
  15. Antioxidative effects of melatonin in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase. Coto-Montes, A., Hardeland, R. J. Pineal Res. (1999) [Pubmed]
  16. Molecular characterization and rescue of acatalasemic mutants of Drosophila melanogaster. Griswold, C.M., Matthews, A.L., Bewley, K.E., Mahaffey, J.W. Genetics (1993) [Pubmed]
  17. Transcriptional regulation of the Drosophila catalase gene by the DRE/DREF system. Park, S.Y., Kim, Y.S., Yang, D.J., Yoo, M.A. Nucleic Acids Res. (2004) [Pubmed]
  18. Regulatory role of dADAR in ROS metabolism in Drosophila CNS. Chen, L., Rio, D.C., Haddad, G.G., Ma, E. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  19. The involvement of catalase in alcohol metabolism in Drosophila melanogaster larvae. van der Zel, A., Dadoo, R., Geer, B.W., Heinstra, P.W. Arch. Biochem. Biophys. (1991) [Pubmed]
  20. Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. Le Bourg, E., Minois, N. C. R. Acad. Sci. III, Sci. Vie (1997) [Pubmed]
  21. Decreased mitochondrial hydrogen peroxide release in transgenic Drosophila melanogaster expressing intramitochondrial catalase. Kwong, L.K., Mockett, R.J., Bayne, A.C., Orr, W.C., Sohal, R.S. Arch. Biochem. Biophys. (2000) [Pubmed]
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