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Gene Review

CTA1  -  catalase A

Saccharomyces cerevisiae S288c

Synonyms: Peroxisomal catalase A, YD9320A.06C, YDR256C
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Disease relevance of CTA1


High impact information on CTA1

  • Compared with wild-type cells, adr1 null mutants produced by disruption of the gene exhibit reduced CTA1 expression [3].
  • Expression of the CTA1 gene of Saccharomyces cerevisiae, encoding catalase A, the peroxisomal catalase of this yeast, is sensitive to glucose repression [3].
  • We examined the expression of CYC1-lacZ reporter constructs carrying the SPS19 and CTA1 OREs in diploids propagated under sporulation conditions and have shown that OREs are not sufficient for heterologous expression during yeast development [4].
  • Presence of H(2)O(2) could be detected around necrotic lesions caused by TMV infection in non-transgenic plants but to a much lesser extent in the CTA1 transgenic plants [1].
  • Respiratory incompetence has no effect on the expression of CTA1 and POX1, whereas in the absence of haem their expression is markedly decreased [2].

Biological context of CTA1


Anatomical context of CTA1

  • Furthermore, GFP-Cta1pDeltankf coexpressed with Cta1p was successfully localized in peroxisomes, suggesting that the oligomer was formed prior to peroxisome import and that it is not necessary for all four subunits to possess a PTS motif [8].

Associations of CTA1 with chemical compounds

  • A region previously demonstrated to control CTA1 via the ADR1 transcription activator (bp -156 to -184) does not mediate induction by oleic acid [9].
  • A strain from which CTA1 was deleted (cta1Delta strain) showed marked growth inhibition when it was grown on the peroxisome-inducing carbon sources methanol, oleate, and D-alanine, indicating that peroxisomal catalase plays an important nonspecific role in peroxisomal metabolism [8].
  • 3' Noncoding sequences of the CTA 1 gene enhance expression of the recombinant serine protease inhibitor, CPTI II, in Saccharomyces cerevisiae [10].

Other interactions of CTA1

  • Copper was found to specifically induce transcription of CTT1, but not CTA1, mRNA [11].


  1. Effect of yeast CTA1 gene expression on response of tobacco plants to tobacco mosaic virus infection. Talarczyk, A., Krzymowska, M., Borucki, W., Hennig, J. Plant Physiol. (2002) [Pubmed]
  2. Oxygen and haem regulate the synthesis of peroxisomal proteins: catalase A, acyl-CoA oxidase and Pex1p in the yeast Saccharomyces cerevisiae; the regulation of these proteins by oxygen is not mediated by haem. Skoneczny, M., Rytka, J. Biochem. J. (2000) [Pubmed]
  3. The Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins. Simon, M., Adam, G., Rapatz, W., Spevak, W., Ruis, H. Mol. Cell. Biol. (1991) [Pubmed]
  4. Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium. Gurvitz, A., Rottensteiner, H., Hiltunen, J.K., Binder, M., Dawes, I.W., Ruis, H., Hamilton, B. Mol. Microbiol. (1997) [Pubmed]
  5. Mechanism of DNA binding by the ADR1 zinc finger transcription factor as determined by SPR. Schaufler, L.E., Klevit, R.E. J. Mol. Biol. (2003) [Pubmed]
  6. Sequence of the Saccharomyces cerevisiae CTA1 gene and amino acid sequence of catalase A derived from it. Cohen, G., Rapatz, W., Ruis, H. Eur. J. Biochem. (1988) [Pubmed]
  7. Overexpression of peroxisomal malate dehydrogenase MDH3 gene enhances cell death on H2O2 stress in the ald5 mutant of Saccharomyces cerevisiae. Kurita, O. Curr. Microbiol. (2003) [Pubmed]
  8. Peroxisomal catalase in the methylotrophic yeast Candida boidinii: transport efficiency and metabolic significance. Horiguchi, H., Yurimoto, H., Goh, T., Nakagawa, T., Kato, N., Sakai, Y. J. Bacteriol. (2001) [Pubmed]
  9. A Saccharomyces cerevisiae upstream activating sequence mediates induction of peroxisome proliferation by fatty acids. Filipits, M., Simon, M.M., Rapatz, W., Hamilton, B., Ruis, H. Gene (1993) [Pubmed]
  10. 3' Noncoding sequences of the CTA 1 gene enhance expression of the recombinant serine protease inhibitor, CPTI II, in Saccharomyces cerevisiae. Stankiewicz, M., Rempoła, B., Fikus, M. Acta Biochim. Pol. (1996) [Pubmed]
  11. Regulation of Saccharomyces cerevisiae catalase gene expression by copper. Lapinskas, P., Ruis, H., Culotta, V. Curr. Genet. (1993) [Pubmed]
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