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Gene Review

Myo10  -  myosin X

Mus musculus

Synonyms: AW048724, D15Ertd600e, Unconventional myosin-10, Unconventional myosin-X, mKIAA0799, ...
 
 
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High impact information on Myo10

  • Myosin X regulates netrin receptors and functions in axonal path-finding [1].
  • This integrin relocalization and filopodia elongation did not occur with Myo10 mutants deficient in integrin binding or with a beta(1)-integrin point mutant deficient in Myo10 binding [2].
  • Myosin-X provides a motor-based link between integrins and the cytoskeleton [2].
  • We propose that Myo10 provides a molecular link between PI(3)K and pseudopod extension during phagocytosis [3].
  • Expression of a truncation construct of Myo10 (Myo10 tail) in a macrophage cell line or cytosolic loading of anti-Myo10 antibodies in bovine alveolar macrophages inhibited phagocytosis [3].
 

Biological context of Myo10

 

Anatomical context of Myo10

  • Northern blot analysis revealed the existence of a myosin X mRNA, 8.7 kb in size, in various mouse tissues, while a similar size of human type myosin X mRNA was recognized mainly in the testis [5].
  • Subcellular fractionation experiments with mouse hepatocytes, combined with sodium dodecylsulfate (SDS)-polyacrylamide gel electrophoresis (PAGE)-immunoblot analysis using antibodies against two different tail regions of mouse myosin-X demonstrated a 240 kDa molecular mass to be associated with the plasma membrane-rich P2 fraction [6].
 

Other interactions of Myo10

  • We show that the uw locus is genetically distinct from Myo10, a suggested candidate gene for this mutation [7].
  • Possible involvement of myosin-X in intercellular adhesion: importance of serial pleckstrin homology regions for intracellular localization [6].
 

Analytical, diagnostic and therapeutic context of Myo10

References

  1. Myosin X regulates netrin receptors and functions in axonal path-finding. Zhu, X.J., Wang, C.Z., Dai, P.G., Xie, Y., Song, N.N., Liu, Y., Du, Q.S., Mei, L., Ding, Y.Q., Xiong, W.C. Nat. Cell Biol. (2007) [Pubmed]
  2. Myosin-X provides a motor-based link between integrins and the cytoskeleton. Zhang, H., Berg, J.S., Li, Z., Wang, Y., Lång, P., Sousa, A.D., Bhaskar, A., Cheney, R.E., Strömblad, S. Nat. Cell Biol. (2004) [Pubmed]
  3. Myosin X is a downstream effector of PI(3)K during phagocytosis. Cox, D., Berg, J.S., Cammer, M., Chinegwundoh, J.O., Dale, B.M., Cheney, R.E., Greenberg, S. Nat. Cell Biol. (2002) [Pubmed]
  4. The spatial and temporal dynamics of pleckstrin homology domain binding at the plasma membrane measured by imaging single molecules in live mouse myoblasts. Mashanov, G.I., Tacon, D., Peckham, M., Molloy, J.E. J. Biol. Chem. (2004) [Pubmed]
  5. Mouse myosin X: molecular architecture and tissue expression as revealed by northern blot and in situ hybridization analyses. Yonezawa, S., Kimura, A., Koshiba, S., Masaki, S., Ono, T., Hanai, A., Sonta, S., Kageyama, T., Takahashi, T., Moriyama, A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Possible involvement of myosin-X in intercellular adhesion: importance of serial pleckstrin homology regions for intracellular localization. Yonezawa, S., Yoshizaki, N., Sano, M., Hanai, A., Masaki, S., Takizawa, T., Kageyama, T., Moriyama, A. Dev. Growth Differ. (2003) [Pubmed]
  7. A new allelic series for the underwhite gene on mouse chromosome 15. Sweet, H.O., Brilliant, M.H., Cook, S.A., Johnson, K.R., Davisson, M.T. J. Hered. (1998) [Pubmed]
 
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