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Gene Review

Mybbp1a  -  MYB binding protein (P160) 1a

Mus musculus

Synonyms: AL024407, AU019902, Myb-binding protein 1A, Myb-binding protein of 160 kDa, P160, ...
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Disease relevance of Mybbp1a


High impact information on Mybbp1a

  • In addition, transformation-defective mutants isolated from either the P120 or P160 wild-type strain lack phosphotyrosine-containing peptides [2].
  • Adenoviral expression of p160MBP in myoblasts strongly reduces PGC-1alpha's ability to stimulate mitochondrial respiration and the expression of the genes of the electron transport system [3].
  • We describe here the identification of p160 myb binding protein (p160MBP) as a repressor of PGC-1alpha [3].
  • A molecular clone of Ab-MuLV (P160 strain) was transfected into the psi 2 packaging cell line, and helper virus-free Ab-MuLV (psi 2) was harvested from the supernatant medium [4].
  • Immunoprecipitation of viral-encoded proteins in helper virus-free tumor cell lines detected the P160 Ab-MuLV-transforming protein; however, no trace of the gag, pol, and env helper virus-encoded proteins was found [4].

Biological context of Mybbp1a

  • In this study we show that Mybbp1a is a nucleocytoplasmic shuttling protein and investigate the mechanisms responsible for both nuclear import and export [5].
  • The P160 gene is located on mouse chromosome 11, and related sequences are found on chromosomes 1 and 12 [6].
  • Myb-binding protein 1a augments AhR-dependent gene expression [1].
  • An isolate of A-MuLV which encoded a 160,000-dalton transforming protein (P160) contained 700 more base pairs of mouse sequences than the standard A-MuLV isolate, which encoded a 120,000-dalton transforming protein (P120) [7].
  • The coding sequences required for this region and for the expression of L-v-abl were identified by replacing sequences in the P120 virus genome, which did not express L-v-abl, with sequences from the P160 virus genome [8].

Anatomical context of Mybbp1a

  • Two of these strains, the standard P120- and the P160-producing viruses, transformed lymphoid cells efficiently in vitro and induced Abelson disease in vivo [9].
  • In the cochlea, CDH23Delta68 expression is highest at postnatal day 1 (P1) and P7; expression is down regulated through P14 and P21 and persists at a low steady-state level throughout adulthood (P160) [10].

Associations of Mybbp1a with chemical compounds


Other interactions of Mybbp1a

  • The carboxyl terminus of Mybbp1a, which contains seven short basic amino acid repeat sequences, is responsible for both nuclear and nucleolar localization, and this activity can be transferred to a heterologous protein [5].

Analytical, diagnostic and therapeutic context of Mybbp1a

  • Cell lines that reached the advanced stage of feeder-independent agar growth showed increased detection by antiphosphotyrosine Western blot of the GAP-associated p62 phosphoprotein as well as of a 55 kDa phosphoprotein while detection of the P160 v-abl phosphoprotein remained constant throughout all stages of progression [11].


  1. Myb-binding protein 1a augments AhR-dependent gene expression. Jones, L.C., Okino, S.T., Gonda, T.J., Whitlock, J.P. J. Biol. Chem. (2002) [Pubmed]
  2. In vivo tyrosine phosphorylations of the Abelson virus transforming protein are absent in its normal cellular homolog. Ponticelli, A.S., Whitlock, C.A., Rosenberg, N., Witte, O.N. Cell (1982) [Pubmed]
  3. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan, M., Rhee, J., St-Pierre, J., Handschin, C., Puigserver, P., Lin, J., Jäeger, S., Erdjument-Bromage, H., Tempst, P., Spiegelman, B.M. Genes Dev. (2004) [Pubmed]
  4. Cell transformation and tumor induction by Abelson murine leukemia virus in the absence of helper virus. Green, P.L., Kaehler, D.A., Risser, R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  5. Myb-binding protein 1a is a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways. Keough, R.A., Macmillan, E.M., Lutwyche, J.K., Gardner, J.M., Tavner, F.J., Jans, D.A., Henderson, B.R., Gonda, T.J. Exp. Cell Res. (2003) [Pubmed]
  6. Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb. Tavner, F.J., Simpson, R., Tashiro, S., Favier, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Macmillan, E.M., Lutwyche, J., Keough, R.A., Ishii, S., Gonda, T.J. Mol. Cell. Biol. (1998) [Pubmed]
  7. Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences. Dale, B., Ozanne, B. Mol. Cell. Biol. (1981) [Pubmed]
  8. A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitro. Watanabe, S.M., Rosenberg, N.E., Witte, O.N. J. Virol. (1984) [Pubmed]
  9. Abelson murine leukemia virus mutants deficient in kinase activity and lymphoid cell transformation. Rosenberg, N.E., Clark, D.R., Witte, O.N. J. Virol. (1980) [Pubmed]
  10. Sustained cadherin 23 expression in young and adult cochlea of normal and hearing-impaired mice. Rzadzinska, A.K., Derr, A., Kachar, B., Noben-Trauth, K. Hear. Res. (2005) [Pubmed]
  11. Increased detection of specific tyrosine phosphoproteins correlates with tumor progression of Abelson virus-infected lymphocytes. Clark, S.S., Liang, Y. Leukemia (1995) [Pubmed]
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